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Ginsenoside Rb1 Protects Human Umbilical Vein Endothelial Cells against High Glucose-Induced Mitochondria-Related Apoptosis through Activating sirt3 signalling pathway

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Chinese Journal of Integrative Medicine 2021年第5期27卷 336-344页

作者： KE Shi-ye YU Shu-jie LIU Ding-hui SHI Guang-yao WANG Min ZHOU Bin WU Lin SONG Zhi-ming ZHU Jie-ming WU Chao-dong QIAN Xiao-xian Department of Cardiology the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630China Department of Cardiology the Eighth Affiliated Hospital of Sun Yat-Sen UniversityShenzhenGuangdong Province 518033China Department of Cardiology the First Affiliated Hospital of Henan UniversityKaifengHenan Province 475001China Department of Nutrition and Food Science Texas A&M UniversityCollege StationTX 77843United States of America Institute of Integrated Traditional Chinese and Western Medicine Sun Yat-Sen UniversityGuangzhou 510630China

Objective:To investigate whether ginsenoside Rb1(Rb1)can protect human umbilical vein endothelial cells(HUVECs)against high glucose-induced apoptosis and examine the underlying ***:HUVECs were divided into 5 groups:control group(5.5 mmol/L glucose),high glucose(HG,40 mmol/L)treatment group,Rb1(50μmol/L)treatment group,Rb1 plus HG treatment group,and Rb1 and 3-(1 H-1,2,3-triazol-4-yl)pyridine(3-TYP,16μmol/L)plus HG treatment *** viability was evaluated by cell counting kit-8 *** and intracellular reactive oxygen species were detected by Mito Sox Red mitochondrial superoxide indicator and dichloro-dihydro-fluorescein diacetate assay,*** V/propidium iodide staining and fluorescent dye staining were used to measure the apoptosis and the mitochondrial membrane potential of HUVECs,*** protein expressions of apoptosis-related proteins[Bcl-2,Bax,cleaved caspase-3 and cytochrome c(Cyt-c)],mitochondrial biogenesis-related proteins[proliferator-activated receptor gamma coactivator 1-alpha,nuclear respiratory factor-1 and mitochondrial transcription factor A],acetylation levels of forkhead box O3 a and SOD2,and sirtuin-3(sirt3)signalling pathway were measured by immunoblotting and ***:Rb1 ameliorated survival in cells in which apoptosis was induced by high glucose(Psirt3 signalling pathway activation(P<0.01).The effect of Rb1 against high glucose-induced mitochondria-related apoptosis wa

关键词： ginsenoside Rb1 high glucose human umbilical vein endothelial cells apoptosis mitochondria sirt3 signalling pathway

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