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A photopatterned sers substrate with a sandwich structure for multiplex detection

Chinese Chemical Letters 2022年第3期33卷 1595-1598页

作者： Yuan Xue Duo Liu Xuebin Wang Yanxin Xiang Shengjie Du Kai Ye Chunyan Bao Linyong Zhu Shanghai Key Laboratory of Functional Materials Chemistry School of Chemistry&Molecular EngineeringEast China University of Science&TechnologyShanghai 200237China

Substrate photopatterning has provided versatile applications in biomedical fields. Herein, an universal and efficient photoligation reaction has been used to prepare a patterned capture substrate for a sandwich sers immunoassay. Photoirradiation induces mild and efficient immobilization of antibodies at the desired region of a gold surface, and the antibody-antigen interaction helps the substrate to capture the antigens in solution specifically. After exposing to sers probes, i.e., the gold nanoparticles labelled with both antibodies and intrinsically strong Raman reporters, multiple quantitative sers determination of antigens can be achieved with high sensitivity and specificity. The limit of detection can be as low as 10^(-12) mol/L for four kinds of cancer biomarkers, which provides a promising method for the construction of highly sensitive and high-throughput sers detection chip and the application of in vitro diagnosis.

关键词： sers detection Photopatterning Sandwich structure Multiplex detection Quantitative detection

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Cystine-assisted accumulation of gold nanoparticles on ZnO to construct a sensitive surface-enhanced Raman spectroscopy substrate

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Frontiers of Chemical Science and Engineering 2023年第1期17卷 15-23页

作者： Qi Qu Chuan Zeng Jing Huang Mengfan Wang Wei Qi Zhimin He School of Chemical Engineering and Technology State Key Laboratory of Chemical EngineeringTianjin UniversityTianjin 300072China School of Life Sciences Tianjin UniversityTianjin 300072China Co-Innovation Centre of Chemistry and Chemical Engineering of Tianjin Tianjin 300072China Tianjin Key Laboratory of Membrane Science and Desalination Technology Tianjin 300350China Technical Centre of Gongbei Customs District of China Zhuhai 519000China

Recently,various semiconductor/metal composites have been developed to fabricate surfaceenhanced Raman spectroscopy ***,low metal loading on semiconductors is still a *** this study,cystine was introduced to increase the accumulation of gold nanoparticles on zinc oxide,owing to the biomineralization_property of_*** analysis revealed that the obtained ZnO/Au/cystine composite not only had a higher metal loading but also formed a porous structure,which is beneficial for Raman *** with ZnO/Au,the ZnO/Au/cystine substrate displayed a 40-fold enhancement in the Raman signal and a lower limit of detection(10^(-11) mol·L^(-1))in the detection of rhodamine ***,the substrate has favorable homogeneity and ***,ZnO/Au/cystine displayed excellent performance toward crystal violet and methylene blue in a test based on river water *** study provided a promising method to fabricate sensitive semiconductor/noblemetal-based surface-enhanced Ramans spectroscopy substrates for Raman detection.

关键词： biomineralization cystine semiconductor/metal composite sers detection Raman detection

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