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Quantitative CT Indexes and CT Visual score in Interstitial Lung Abnormality as Indicators of Concurrent Lung Cancer

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Open Journal of Radiology 2019年第2期9卷 105-114页

作者： Akihiro Hotta Kazuhiro Suzuki Mariko Fukui Katsutoshi Ando Kenji Suzuki Ryohei Kuwatsuru Kazuya Takamochi Departments of Radiology Faculty of Medicine Juntendo University Tokyo Japan Departments of Thoracic Surgery Faculty of Medicine Juntendo University Tokyo Japan Departments of Respiratory Medicine Faculty of Medicine Juntendo University Tokyo Japan

Background: The associations between the severity of interstitial lung disease and the stage and histologic type of concurrent lung cancer remain unknown. Purpose: To evaluate whether the severity of interstitial lung abnormality (ILA), as indicated by quantitative computed tomographic (CT) indexes and CT visual score, was correlated with the stage and histological type of concurrent lung cancer. Materials and Methods: Twenty-eight patients with surgically diagnosed lung cancer and ILA on CT were enrolled in this retrospective study. The subjects were allocated to one of three groups by histological type: adenocarcinoma group (13 subjects);squamous cell carcinoma group (10 subjects);and the other histological diagnosis group (5 subjects). Two independent observers evaluated the CT findings to determine the CT visual score, and the kurtosis and skewness of CT-based density histograms were determined. The relationships between severity of ILA and the pathological stage and histological type of concurrent lung cancer were evaluated. Results: There were no significant differences in the CT visual scores and quantitative indexes among the three groups. CT visual score was significantly negatively correlated with pathological stage (r = −0.43, P = 0.025). Conclusion: Patients can have only mild ILA on visual scoring but advanced lung cancer. Therefore, the frequency of follow-up examination should not be based on the severity of ILA on CT.

关键词： CT Visual score Interstitial Lung Disease Lung Cancer Quantitative CT Index

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改进的Fisher score特征选择方法及其应用

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辽宁工程技术大学学报（自然科学版） 2019年第5期38卷 472-479页

作者：吴迪郭嗣琮辽宁工程技术大学理学院辽宁阜新123000 辽宁工程技术大学智能工程与数学研究院辽宁阜新123000

为了更加完整地刻画出传统Fisher score在某些分布不均匀情况下未体现出的类间差异,同时弥补对两类间交叉关系的考虑,采取新的类间散度度量公式,加入度量两类重复度的交叉系数,并引入最大互信息系数对公式进行修正,提出了改进的FisherSc... 详细信息

为了更加完整地刻画出传统Fisher score在某些分布不均匀情况下未体现出的类间差异,同时弥补对两类间交叉关系的考虑,采取新的类间散度度量公式,加入度量两类重复度的交叉系数,并引入最大互信息系数对公式进行修正,提出了改进的Fisherscore,对比实验验证了改进方法的有效性.结果表明:改进的Fisherscore可以度量出更多的数据分布情况,在分布不均匀但同属于一个类中心的数据中,改进方法可以将更重要的特征辨识出来,完善了传统的Fisher score特征选择方法.

关键词： Fisher score 类间散度交叉系数最大互信息系数特征选择人脸识别

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Predictive Factors of the Presence and Number of Noncalcified Coronary Plaque in Japanese Patients with Zero Coronary Artery Calcium score Using 64-Slice Multi-Detector Computed Tomography

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Advances in Computed Tomography 2013年第3期2卷 112-120页

作者： Yoshiki Noda Ryo Matsutera Yoshinori Yasuoka Kiyoshi Kume Hidenori Adachi Susumu Hattori Ryo Araki Motohiro Kosugi Yasuaki Kohama Tetsufumi Nakashima Tatsuya Sasaki Cardiovascular Division Osaka Minami Medical Center National Hospital Organization Osaka Japan

Background: Factors that can predict the presence and number of noncalcified coronary plaques (NCP) in Japanese patients with zero coronary artery calcium scores (CACS) essentially remain undefined. Methods and Results: We assessed independent predictors of the presence and number of segments with NCP in 111 Japanese patients with zero CACS who underwent 64-slice multi-detector computed tomography at our hospital. Thirty five patients (32%) had NCP, and 24 patients (22%) had ≥ 2 NCPs. Multiple logistic regression analysis revealed that significant predictors for the presence of NCP were age (odds ratio [OR]: 1.06, 95% confidence interval [CI] 1.01 - 1.11, p = 0.021), male (OR: 3.61, 95% CI 1.40 - 9.35, p = 0.008) and diabetes mellitus (OR: 3.10, 95% CI 1.02 - 9.45, p = 0.046), and those for the presence of ≥ 2 NCPs were age (OR: 1.08, 95% CI 1.02 - 1.15, p = 0.007) and a current smoking habit (OR: 5.09, 95% CI 1.00 - 25.74, p = 0.049). Multiple linear regression analysis identified advanced age, male gender and diabetes mellitus as independent predictors of the number of NCPs. A novel score calculated from the above four predictors showed moderate accuracy for a diagnosis of NCP and ≥ 2 NCPs, with areas under receiver operating curves of 0.738 and 0.736, respectively. Conclusions: Male Japanese patients with zero CACS, advanced age, diabetes mellitus and a current smoking habit might have NCPs.

关键词： Zero Coronary Artery Calcium score Number of Noncalcified Coronary Plaque 64-Slice Multi-Detector Computed Tomography Japanese Patients

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肿瘤基因选择方法LLE score

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北京工业大学学报 2015年第8期41卷 1145-1150页

作者：李建更逄泽楠苏磊陈思远北京工业大学电子信息与控制工程学院北京100124 计算智能与智能系统北京市重点实验室北京100124 吉林大学机械科学与工程学院长春130025

针对处理肿瘤基因表达数据特征选择问题,提出了一种特征选择方法 LLE score.该方法是典型的过滤器类型特征选择方法,在样本类别信息的基础上,LLE score针对特征向量的局部邻域保存能力进行评价,并且根据评价结果进行特征的选取,以此达... 详细信息

针对处理肿瘤基因表达数据特征选择问题,提出了一种特征选择方法 LLE score.该方法是典型的过滤器类型特征选择方法,在样本类别信息的基础上,LLE score针对特征向量的局部邻域保存能力进行评价,并且根据评价结果进行特征的选取,以此达到良好的特征选择效果.在实验部分对肿瘤数据集进行特征选择,并采用支持向量机分类器计算分类准确率.通过分类准确率说明了该方法的有效性.

关键词： LLE score 特征选择肿瘤基因表达数据

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score丙烷回收流程模拟与分析

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石油与天然气化工 2017年第6期46卷 39-44页

作者：朱聪张世坚蒋洪西南石油大学机电工程学院西南石油大学石油与天然气工程学院

单塔塔顶循环(score)工艺是国外广泛采用的一种低温分离流程,主要用于回收天然气中丙烷及比丙烷更重组分,是在塔顶循环(OHR)丙烷回收流程基础上的一种改进丙烷回收工艺,该工艺流程具有流程简单、丙烷回收率高、系统热集成度高、对气质... 详细信息

单塔塔顶循环(score)工艺是国外广泛采用的一种低温分离流程,主要用于回收天然气中丙烷及比丙烷更重组分,是在塔顶循环(OHR)丙烷回收流程基础上的一种改进丙烷回收工艺,该工艺流程具有流程简单、丙烷回收率高、系统热集成度高、对气质适应性强等特点。分析了score工艺流程结构、工艺原理及流程特征,流程中脱乙烷塔采用复合塔,由吸收段与分馏段组合而成,侧线气相抽出物流经冷凝分别为吸收段提供回流和侧线气相抽出补充物料,低温侧线液相抽出物流预冷原料气可降低重沸器负荷,提高系统热集成度和丙烷回收率。重点通过实例分析塔顶回流、气相及液相抽出物流等操作条件对score流程的丙烷回收率及系统能耗的影响。并选取3组不同气质对score流程进行适应性分析,结果表明,score流程是一种回收率高、适应性较宽的高效丙烷回收流程,值得在我国丙烷回收工程领域推广应用。

关键词： score 丙烷回收流程特性适应性

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Determinants of Outcomes and Prognosis score in Obstetric Vesico-Vaginal Fistula Repair

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Open Journal of Obstetrics and Gynecology 2017年第7期7卷 767-777页

作者： Leon Mubikayi David O. Matson Vicky Lokomba Justin Mboloko Jean Patrick Kamba Rahma Tozin School of Medicine Kasayi University Kananga Democratic Republic of the Congo (DRC) Graduate Program in Public Health Eastern Medical School Norfolk USA Department of Pediatrics Eastern Virginia Medical School Norfolk USA School of Medicine University of Kinshasa Kinshasa Democratic Republic of the Congo (DRC)

An estimated 2 million women living in countries with limited resources currently have vesico-vaginal, recto-vaginal, or mixed types of fistulae because of the necrosis that occurs with obstructed labor. We evaluated factors readily assessed by the examining practitioner in a consecutive case series of surgical repairs of obstetrical fistulae, for the ability of those factors to stand as a prognostic guide, in a clinical score. Objectives: To identify the predictors of surgical repair outcomes and establish a score combining these different determinants to facilitate the care of obstetric fistula. Methods: We conducted a multicentric prospective study between 2011 and 2014 in Democratic Republic of the Congo (DRC). Outcomes: We measured 3 months post-surgery in a series of 483 patients with obstetrical fistula repaired by the same surgeon included closure and failure appreciated by dye test. Multivariable generalized estimating equation models were used to generate adjusted odd ratios (OR) and 95% confidence intervals (CIs). The scores ranging from 3 to 14 were established from the outcomes determinants identified. Results: In total, 483 women were enrolled, and 390 cases were at their first surgery and were included in the obstetric fistula (OF) prognosis score and classification. Their mean age was 35 years at the time of the surgery and 25 years at the onset of OF. In 28.6%, the fistula patient was primigravida. Mean duration between onset of the fistula and surgical treatment was 8 years. In 24%, the fistula patients lived separated from their partners. Overall closure rate of the fistulas was 85.7%. Severe vaginal fibrosis (p 0.01), big fistula size (0.01), small distance from fistula to external urethral meatus (0.01) and prior surgery (p 0.48) predicted failed fistula closure. A clinical score ranging from 3 to 14 points is a prognostic score with a range of 1 to 4 for the distance between the fistula and the external meatus and the size, and a scale of 1 to

关键词： Obstetrical Fistula Repair Outcomes Prognosis score

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Day 100 Absolute Monocyte/Lymphocyte Prognostic score and Survival Post Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation in Diffuse Large B-Cell Lymphoma

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Journal of Cancer Therapy 2013年第8期4卷 1298-1305页

作者： Ana I. Velazquez David J. Inwards Stephen M. Ansell Ivana N. Micallef Patrick B. Johnston William J. Hogan Svetomir N. Markovic Luis F. Porrata Division of Hematology Department of Internal Medicine Mayo Clinic Rochester USA

Day 100 prognostic factors post-autologous peripheral blood hematopoietic stem cell transplantation (APBHSCT) to predict clinical outcomes in diffuse large B-cell lymphoma (DLBCL) patients have not been studied. Thus, we retrospectively examined if day 100 absolute monocyte/lymphocyte prognostic score (AMLPS-100) affects clinical outcomes by landmark analysis from day 100 post-APBHSCT in DLBCL. Only DLBCL patients in complete remission at day 100 post-APBHSCT were evaluated. From 2000 to 2007, 134 consecutive DLBCL patients are qualified for the study. Patients with a day 100 absolute monocyte count (AMC-100) ≥ 630 cells/μL and day 100 absolute lymphocyte count (ALC-100) ≤ 1000 cells/μL experienced inferior overall survival (OS) and progression free survival (PFS). On multivariate analysis, the AMC-100 and ALC-100 remained independent predictors of OS and PFS. Combining both values into the AMLPS-100, the 5-year OS rates for low, intermediate, and high AMLPS-100 risk groups were 94% (95% CI, 83.0% - 98.1%), 70% (95% CI, 58.6% - 80.1%), and 13% (95% CI, 3.4% - 40.5%), respectively;and the 5-year PFS rates were 87% (95% CI, 74.0% - 94.1%), 68% (95% CI, 56.0% - 77.8%), and 13% (95% CI, 3.4% - 40.5%), respectively. The AMLPS-100 is a simple biomarker score that can stratify clinical outcomes from day 100 post-APBHSCT in DLBCL patients.

关键词： Monocyte/Lymphocyte Prognostic score Diffuse Large B-Cell Lymphoma Survival Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation

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Iatrogenic opioid dependence is endemic and legal: Genetic addiction risk score (GARS) with electrotherapy a paradigm shift in pain treatment programs

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Health 2013年第11期5卷 16-34页

作者： Kenneth Blum David Han Marlene Oscar-Berman Gary Reinl Nicholas DiNubile Margaret A. Madigan Anish Bajaj Bernard William Downs John Giordano Wayne Westcott Leonard Smith Eric R. Braverman Kristina Dushaj Mary Hauser Thomas Simpatico Thomas McLaughlin Joan Borsten Debmayla Barh Center for Psychiatric Medicine North Andover USA Centre for Genomics and Applied Gene Technology Institute of Integrative Omics and Applied Biotechnology (IIOAB) Nonakuri Purba Medinipur India Department of Addiction Research & Therapy Malibu Beach Recovery Center Malibu Beach USA Department of Executive Health Path Research Foundation NY New York USA Department of Exercise Science Quincy College Quincy USA Department of Holistic Medicine and Pain Track National Institute for Holistic Addiction Studies North Miami Beach USA Department of Management Science and Statistics The University of Texas at San Antonio San Antonio USA Department of Molecular Nutrition Impact Genomics Inc. Austin USA Igene LLC Austin USA Department of Psychiatry Anatomy & Neurobiology Boston VA and Boston University School of Medicine Boston USA Department of Psychiatry College of Medicine & McKnight Brain Institute University of Florida Gainesville USA Department of Executive Health Path Research Foundation NY New York USA Department of Psychiatry College of Medicine & McKnight Brain Institute University of Florida Gainesville USA Electronic Waveform Lab Department of Pain Research Huntington Beach USA Department of Orthopedic Surgery Hospital of the University of Pennsylvania Philadelphia USA Department of Molecular Nutrition Impact Genomics Inc. Austin USA Department of Executive Health Path Research Foundation NY New York USA Department of Holistic Medicine and Pain Track National Institute for Holistic Addiction Studies North Miami Beach USA Dominion Diagnostics LLC North Kingstown USA Department of Psychiatry Human Integrated Services Unit of Vermont Center for Clinical & Translational Science University of Vermont College of Medicine Burlington USA Department of Addiction Research & Therapy Malibu Beach Recovery Center Malibu Beach USA Centre for Genomics and Applied Gene Technology Institute of Integrative Omics and Applied Biotechnology (IIOAB) Nonakuri Purba Me

The mounting endemic of prescription iatrogenic opioid dependence in pain patients provoked this treatise about an alternative method that can be used to treat pain, improve function and reduce the risk of opioid dependence. It is well known that as well as the side effects reported for chronic opioid therapy, genetically predisposed individuals are at risk for opioid dependence. We propose the use of the Genetic Addiction Risk score (GARS) assessment to identify patients early in treatment who should avoid narcotic pain medications. Primarily, this review will be an exploration of the mechanisms of action of an electrotherapeutic alternative to narcotic treatment that can be used to augment tissue healing and reduce the pain associated with human injuries and neuropathies. This particular electrotherapeutic device was developed at the Electronic Waveform Laboratory in Huntington Beach, California and is called the H-Wave? device. The primary effect of the H-Wave?device is stimulation (HWDS) of small diameter fibers of “red-slow-twitch” skeletal muscle. Mechanisms of action of HWDS have been investigated in both animal and human studies. They include edema reduction, induction of nitric oxide dependent augmented microcirculation and angiogenesis, small muscle contraction that eliminates transcapillary fluid shifts, reducing the painful effects of tetanizing fatigue and gradual loading of healing injured muscle tissue that helps repair and remodeling. A recent metaanalysis found a moderate-to-strong-positive effect of the HWDS in providing pain relief, reducing the requirement for pain medication, with the most robust effect being increased functionality. We are proposing that GARS can be used to identify those at risk of developing opioid dependence and that the need for opioid analgesia can be reduced by use of this electro therapeutic alternative to opioid analgesia in the treatment of pain and injuries.

关键词： Microcirculation Angiogenesis Analgesic Therapy Electrical Device Stimulation Tissue Loading Remodeling Genetic Addiction Risk score (GARS) Reward Deficiency Syndrome (RDS)

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score丙烷回收流程特性模拟分析

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天然气化工—C1化学与化工 2017年第3期42卷 78-85页

作者：张世坚蒋洪西南石油大学石油与天然气工程学院四川成都610500

score(单塔塔顶循环)工艺是国外应用较多的一种丙烷回收工艺,该工艺具有流程简单、丙烷回收率高、节能效果好以及可操作性好等优点。score流程有别于国内常用的丙烷回收流程,其主要特点有:(1)采用单塔结构;(2)采用侧线重沸器;(3)采用侧... 详细信息

score(单塔塔顶循环)工艺是国外应用较多的一种丙烷回收工艺,该工艺具有流程简单、丙烷回收率高、节能效果好以及可操作性好等优点。score流程有别于国内常用的丙烷回收流程,其主要特点有:(1)采用单塔结构;(2)采用侧线重沸器;(3)采用侧线采出回流;(4)采用分流换热。运用HYSYS软件对score流程特性进行模拟分析,以塔里木轮南轻烃回收工程为例分析了包括脱乙烷塔塔塔压、入口原料气分流比、侧线气相采出量及回流分流比、侧线液相采出量等操作变量对丙烷回收率及能耗的影响及规律。并选用多组典型凝析气田气及油田伴生气对score流程进行适应性分析,分析结果表明适应性均较强,针对油田伴生气气质特点提出了取消侧线液相采出的改进方案,改进后节能效果明显,当原料气处理量较小时,宜去掉回流下部分流。

关键词： score 丙烷回收流程特性能耗操作变量

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Syntax score: The fallacies and remedies—A perspective

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World Journal of Cardiovascular Diseases 2013年第7期3卷 448-453页

作者： Pravin K. Goel Roopali Khanna Aditya Batra Sanjeev K. Syal Department of Cardiology Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India

The syntax score devised as a tool to grade complexity of coronary artery disease with a view to its suitability for PCI or otherwise on deeper introspection is fraught with some inherent limitations and fallacies largely as a result of the variability in coronary anatomy and the fixed nomenclature of the devised scoring system. We, in this special report, bring out the limitations and fallacies in the same and possible remedies presented as a viewpoint which may be useful to the interventional community at large.

关键词： Syntax score PCI

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