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Expression of the sars-cov-2 cell receptor gene ACE2 in a wide variety of human tissues

Infectious Diseases of Poverty 2020年第2期9卷 23-29页

作者： Meng-Yuan Li Lin Li Yue Zhang Xiao-Sheng Wang Biomedical Informatics Research Lab School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 211198China Big Data Research Institute China Pharmaceutical UniversityNanjing 211198China Pinghu hospital of Shenzhen University Shenzhen 440307China Futian Hospital for Rheumatic Diseases Shenzhen 518000China Department of Rheumatology and Immunology The First Clinical College of Harbin Medical UniversityHarbin 150001China

Background:Since its discovery in December 2019,severe acute respiratory syndrome coronavirus 2(sars-cov-2)has infected more than 2180000 people worldwide and has caused more than 150000 deaths as of April 16,***-cov-2,which is the virus causing coronavirus disease 2019(covID-19),uses the angiotensin-converting enzyme 2(ACE2)as a cell receptor to invade human ***,ACE2 is the key to understanding the mechanism of sars-cov-2 *** study is to investigate the ACE2 expression in various human tissues in order to provide insights into the mechanism of sars-cov-2 ***:We compared ACE2 expression levels across 31 normal human tissues between males and females and between younger(ages≤49 years)and older(ages>49 years)persons using two-sided Student's t *** also investigated the correlations between ACE2 expression and immune signatures in various tissues using Pearson's correlation ***:ACE2 expression levels were the highest in the small intestine,testis,kidneys,heart,thyroid,and adipose tissue,and were the lowest in the blood,spleen,bone marrow,brain,blood vessels,and ***2 showed medium expression levels in the lungs,colon,liver,bladder,and adrenal ***2 was not differentially expressed between males and females or between younger and older persons in any *** the skin,digestive system,brain,and blood vessels,ACE2 expression levels were positively associated with immune signatures in both males and *** the thyroid and lungs,ACE2 expression levels were positively and negatively associated with immune signatures in males and females,respectively,and in the lungs they had a positive and a negative correlation in the older and younger groups,***:Our data indicate that sars-cov-2 may infect other tissues aside from the lungs and infect persons with different sexes,ages,and races *** different host immune responses to sars-cov-2 infection may partially explain why males and femal

关键词： sars-cov-2 covID-19 sars-cov-2 cell receptor Angiotensin-converting enzyme 2 Gene expression sars-cov-2 pandemic Immune signatures

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