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Therapeutic Implications of Monoclonal Antibody

Journal of Biosciences and Medicines 2023年第3期11卷 85-104页

作者： Mohammad Shane Alam Farhana Riyaz Shah Muntser Mohammad Fadoul Alhassen Saif Elden B. Abdalla Abdul Mateen Md. Shakir Ahmad Department of Medical Laboratory Technology College of Applied Medical Sciences Jazan University Jazan Saudi Arabia Ageing Research Laboratory Department of Zoology Lalit Narayan Mithila University Darbhanga India Department of Pathology Darbhanga Medical College Darbhanga India

Background: The coronavirus disease 2019 (covid-19) pandemic is a distinct public health issue that calls for the quick development of novel treatments and viral detection. Due to their high specificity and reliability, monoclonal antibodies (mAbs) have emerged as useful diagnostic and therapeutic tools for a variety of diseases. As a result, several scientists have jumped right into developing Ab-based assays for the identification of sars-cov-2 and Ab drugs for use as covid-19 therapy agents. Since the receptor-binding domain (RBD) of the sars-cov-2 spike protein is essential for viral infection and has a known precise structure, it has become a key target for the creation of therapeutic antibodies. The use of Ab cocktails is anticipated to be a key component of an efficient covid-19 treatment plan since sars-cov-2 is an RNA virus with a high mutation rate, particularly when subjected to the selection pressure of aggressively applied preventive vaccinations and neutralizing Abs. Furthermore, sars-cov-2 infection could provoke an overzealous immune response, leading to a cytokine storm that accelerates the onset of a severe disease. Abs to counteract cytokine storms are also actively being researched as covid-19 therapies. Abs are now used in sars-cov-2 detection assays, including immunoglobulin and antigen tests, in addition to their use as medicines. In order to stop the spread of covid-19, such Ab-based detection tests are essential surveillance tools. In this article, we’ll go over several important ideas related to mAb-based covid-19 pandemic detection tests and treatments. Objective: To understand the role of hybridoma technology in therapeutic implications. 1) To study the basic concepts and options in hybridoma technology;2) To study the applications of hybridoma technology;3) To explore how hybridoma technology is applied in diagnostic histopathology. Method: For this method generally there is use of mouse or mammals are transfect with the Ags to find out

关键词： Monoclonal Antibody Cancerous Cell Receptor-Binding Domain (RBD) Immune System sars-cov-2 and covid-19

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