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Prolonged Viral Shedding in Three Young Adult Cases of covID-19

Infectious Diseases & Immunity 2022年第4期2卷 289-292页

作者： Wen-Yi Dong Ming-Ju Zhou Lei Huang Chao Zhang Fu-Sheng Wang Zhou-Hua Xie Guangxi AIDS Clinical Treatment Centre The Fourth People’s Hospital of NanningNanning 530013China Beijing Ditan Hospital Capital Medical UniversityBeijing 100015China Medical Department of Infectious Diseases The Fifth Medical Centre of Chinese PLA General HospitalNational Clinical Research Centre for Infectious DiseasesBeijing 100039China

Severe acute respiratory syndrome coronavirus-2 infection is usually self-limited,with a short duration for viral shedding within several ***,prolonged viral shedding has been observed in severe or immune-compromised coronavirus disease 2019(covID-19)***,we reported that three young adult cases of covID-19 patients,who were either immunosuppressed nor severe,showed prolonged viral RNA shedding from the upper respiratory tract for 58,81,and 137 days since initial *** our knowledge,this is the longest duration of viral shedding reported to date in young adult *** studies on factors relevant to prolonged viral positivity,as well as the correlation between viral positivity and transmission risk are needed for the optimal management of covID-19 patients with prolonged nucleic acid positive.

关键词： covID-19 Immune-competent Prolonged viral shedding sar-cov-2

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Development of a rapid test kit for sarS-cov-2:an example of product design

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Bio-Design and Manufacturing 2020年第2期3卷 83-86页

作者： Zhanfeng Cui Hong Chang Hui Wang Boon Lim Chia-Chen Hsu Yejiong Yu Huidong Jia Yun Wang Yida Zeng Mengmeng Ji Weizhi Liu Catriona Inverarity Wei E.Huang Oxford Suzhou Centre for Advanced Research(OSCAR) University of OxfordSuzhouJiangsuPeople's Republic of China Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK Department of Engineering Science Institute of Biomedical EngineeringUniversity of OxfordOxford OX37DQUK

We present an example of applying'need-driven'product design principle to the development of a rapid test kit to detect sarS-cov-2(covID-19).The tests are intended for use in the field and,longer term,for home *** detect whether a subject is currently infected with the virus and is *** urgent need for large numbers of tests in field setting imposes constraints such as short test time and lack of access to specialist equipment,laboratories and skilled technicians to perform the test and interpret *** meet these needs,an antigen test based on RT-LAMP with colorimetric readout was *** use of swab sample with no RNA extraction was *** extensive experimental study(reported elsewhere),a rapid test kit has been fabricated to satisfy all design criteria.

关键词： covID-19 Antigen detection Rapid test Product design sar-cov-2 RT-LAMP

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Review of pharmacologic and immunologic agents in the management of covID-19

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Biosafety and Health 2021年第3期3卷 148-155页

作者： Marzuq A.Ungogo Mustapha Mohammed Bala N.Umar Auwal A.Bala Garba M.Khalid Department of Veterinary Pharmacology and Toxicology Ahmadu Bello UniversityZaria 810107Kaduna StateNigeria Institute of Infection Immunity and InflammationCollege of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgow G128TAUnited Kingdom School of Pharmaceutical Sciences Universiti Sains Malaysi1Penang City 11800Pulau Pinang StateMalaysia Department of Clinical Pharmacy and Pharmacy Practice Ahmadu Bello UniversityZaria 810107Kaduna StateNigeria Department of Veterinary Microbiology Faculty of Veterinary MedicineAhmadu Bello UniversityZaria 810107Kaduna StateNigeria Department of Pharmacology College of Medicine and Health SciencesFederal UniversityDutse 720231Jigawa StateNigeria Faculty of Pharmaceutical Sciences Bayero UniversityKano P.M.B.3011Kano StateNigeria Department of Pharmaceutical Sciences UniversitàDegli Studi di MilanoVia G.Colombo71Milano 20133Italy

The novel coronavirus disease 2019(covID-19)is the third coronavirus outbreak in the last two *** and re-emerging infections like covID-19 pose serious challenges of the paucity of information and lack of specific cure or *** leaves utilisation of existing scientific data on related viral infections and repurposing relevant aetiologic and supportive therapies as the best control approach while novel strategies are developed and *** promising antiviral agents including lopinavir,ritonavir,remdesivir,umifenovir,darunavir,and oseltamivir have been repurposed and are currently trialled for the care for covID-19 *** therapies for the management of symptoms and to provide support especially in severe and critically ill patients have also been *** review provides an appraisal of the current evidence for the rational use of frontline therapeutics in the management of *** also includes updates regarding covID-19 immunotherapy and vaccine development.

关键词： sar-cov-2 covID-19 Respiratory Drug repurposing Antiviral Supportive therapy Immunotherapy

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