检索结果-南通市图书馆

The endogenous antioxidant ability of royal jelly in Drosophila is independent of Keap1/Nrf2 by activating oxidoreductase activity

引用

Insect Science 2024年第2期31卷 503-523页

作者： Dongjing Wen Jiayu Xie Yao Yuan Lirong Shen Yufeng Yang Wenfeng Chen Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouChina School of Medicine Chongqing UniversityChongqingChina College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhouChina

royal jelly(RJ)is a biologically active substance secreted by the hypopharyngeal and mandibular glands of worker honeybees.It is widely claimed that RJ reduces oxidative stress.However,the antioxidant activity of RJ has mostly been determined by in vitro chemical detection methods or by external administration drugs that cause oxidative stress.Whether RJ can clear the endogenous production of reactive oxygen species(ROS)in cells remains largely unknown.Here,we systematically investigated the antioxidant properties of RJ using several endogenous oxidative stress models of Drosophila.We found that RJ enhanced sleep quality of aging Drosophila,which is decreased due to an increase of oxidative damage with age.RJ supplementation improved survival and suppressed ROS levels in gut cells of flies upon exposure to hydrogen peroxide or to the neurotoxic agent paraquat.Moreover,RJ supplementation moderated levels of ROS in endogenous gut cells and extended lifespan after exposure of flies to heat stress.Sleep deprivation leads to accumulation of ROS in the gut cells,and RJ attenuated the consequences of oxidative stress caused by sleep loss and prolonged lifespan.Mechanistically,RJ prevented cell oxidative damage caused by heat stress or sleep deprivation,with the antioxidant activity in vivo independent of Keap1/Nrf2 signaling.RJ supplementation activated oxidoreductase activity in the guts of flies,suggesting its ability to inhibit endogenous oxidative stress and maintain health,possibly in humans.

关键词： antioxidant biological oxidations Drosophila oxidative stress royal jelly sleep loss

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

royal-jelly-based apitherapy can attenuate damages to male reproductive parameter following nicotine administration

引用

Animal Models and Experimental Medicine 2022年第2期5卷 133-140页

作者： Mahsa Nazar-Zadeh Cyrus Jalili Amene Nikgoftar Fathi Ali Ghanbari Mitra Bakhtiari Department of Anatomical Sciences Medical SchoolKermanshah University of Medical SciencesKermanshahIran Medical Biology Research Center Kermanshah University of Medical SciencesKermanshahIran Department of Anatomical Sciences Medical SchoolArak University of Medical SciencesArakIran

Background:Nicotine administration can generate severe oxidative stress and lipid peroxidation.royal jelly,with its antioxidant properties,acts as a scavenger of reactive oxygen species.This study describes the apitherapy effects of royal jelly on testicular damage following nicotine administration.Methods:Forty-eight male BALB/c mice were divided into 8 groups(n=6):saline,3 different doses of royal jelly(100,150,and 200 mg/kg body weight(BW)per day),nicotine(1.5 mg/kg),and 3 different groups of Nic+Roy(1.5 mg/kg of Nic+100,150,and 200 mg/kg BW per day of royal jelly).Nicotine was administrated intraperitoneally,and royal jelly was prescribed orally for 10 consecutive days.Serum levels of hormones(testosterone,luteinizing hormone,and follicle-stimulating hormone),total antioxidant capacity,nitric oxide(NO)status,malondialdehyde levels,sperm DNA fragmentation,sperm parameters,histopathological changes(H&E staining),immunohistochemistry against apoptotic proteins,and gene expression of Bcl-2,p53,Caspase-3,and Nrf2(real-time PCR)were assessed to evaluate the molecular and histological changes.Results:Hormone levels,sperm parameters,and status of antioxidants were decreased significantly(proyal jelly treatment normalized hormonal and antioxidant characteristics,decreased apoptotic gene expression,increased Nfr2 gene expression,and restored histopathological alteration to the physiological status significantly(proyal jelly upregulates the antioxidant status,inhibits the mitochondrialdependent apoptosis pathway,and increases the rate of proliferation.This therapeutic agent effectively protected the testis against nicotine-associated damages by antioxidant and anti-apoptotic effects.

关键词： antioxidant apitherapy apoptosis damage male nicotine reproduction royal jelly testis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

royal jelly Extract Accelerates Keratinocyte Proliferation, and Upregulates Laminin α3 and Integrin β1 mRNA Expression, via Akt/mTOR/HIF-1α Pathway

引用

Journal of Cosmetics, Dermatological Sciences and Applications 2022年第2期12卷 83-94页

作者： Akihiro Aioi Septem-Soken Osaka Japan

Background: In the previous decade, various benefits and biological activities of royal jelly, applied in alternative and modern medicine, and cosmetics, have been reported. However, the effects of royal jelly extract (RJ) on keratinocytes have not been fully elucidated. Objective: The primary objectives of this study were to reveal the effects of RJ on keratinocytes and explore the underlying mechanism. Methods: HaCaT cells, an immortal human epidermis-derived keratinocyte cell line, were used in this study. Laminin α3 (LAMA3), integrin β1 (ITGB1), and hypoxia-inducible factor-1α (HIF-1α) mRNA expression levels were determined using real-time PCR. Cell proliferation rate was measured using a bromodeoxyuridine uptake assay. Results: RJ treatment upregulated LAMA3, ITGB1 and HIF-1α mRNA expression, and accelerated HaCaT cell proliferation. Akt and mTOR inhibitors suppressed the RJ-induced HIF-1α expression and cell proliferation. HIF-1α silencing abrogated RJ-induced LAMA3 and ITGB1 mRNA expression and cell proliferation, whereas LAMA3 silencing and antibody-mediated ITGB1 blockade did not affect the effects of RJ. Conclusion: RJ upregulates LAMA3 and ITGB1 mRNA expression levels by HIF-1α expression enhancement. In addition, RJ accelerates keratinocyte proliferation via Akt/mTOR/HIF-1α/NF-κB signaling pathway. These suggest that RJ is beneficial for anti-aging, as a skin care product ingredient.

关键词： royal jelly Keratinocyte Proliferation Epidermal Basement Membrane Hypoxia-Inducible Factor-1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of royal jelly Supplementation on Glycemic Control and Oxidative Stress Factors in Type 2 Diabetic Female:A Randomized Clinical Trial

引用

Chinese Journal of Integrative Medicine 2014年第5期20卷 347-352页

作者： Samira Pourmoradian Reza Mahdavi Majid Mobasseri Elnaz Faramarzi Mehrnoosh Mobasseri Nutrition Research Center Tabriz University of Medical SciencesTabrizIran Endocrinology Department of Medicine Faculty Tabriz University of Medical SciencesTabrizIran Student Research Committee Faculty of NutritionTabriz University of Medical SciencesTabrizIran Faculty of Medicine Tabriz University of Medical SciencesTabrizIran

Objective： It has been proposed that royal jelly has antioxidant properties and may improve oxidative stress and glycemic control. Therefore, we investigated the effects of royal jelly supplementation in diabetic females. Methods： In this pilot, parallel design randomized clinical trial, 50 female volunteers with type 2 diabetes were randomly allocated to the supplemented （25, cases） and placebo （25, cases） groups, based on random block procedure produced by Random Allocation Software, given a daily dose of 1,000 mg royal jelly soft gel or placebo, respectively, for 8 weeks. Before and after intervention, glycemic control indices, antioxidant and oxidative stress factors were measured. Results： After royal jelly supplementation, the mean fasting blood glucose decreased remarkably （163.05_± 42.51 mg/dL vs. 149.68 ± 42.7 mg/dL）. royal jelly supplementation resulted in significant reduction in the mean serum glycosylated hemoglobin levels （8.67%± 2.24% vs. 7.05% ± 1.45%, P=0.001） and significant elevation in the mean insulin concentration （70.28 ± 29.16 pmol/L vs. 86.46± 27.50 pmol/L, P=0.01）. Supplementation significantly increased erythrocyte superoxidase dismutase and glutathione peroxidase activities and decreased malondialdehyde levels （P〈0.05）. At the end of study, the mean total antioxidant capacity elevated insignificantly in both groups. Conclusions： On the basis of our findings, it seems that royal jelly supplementation may be beneficial in controlling diabetes outcomes. Further studies with larger sample size are warranted.

关键词： glycemic control oxidative stress royal jelly type 2 diabetes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Differential volatile organic compounds in royal jelly associated with different nectar plants

引用

Journal of Integrative Agriculture 2016年第5期15卷 1157-1165页

作者： ZHAO Ya-zhou LI Zhi-guo TIAN Wen-li FANG Xiao-ming SU Song-kun PENG Wen-jun Institute of Apicultural Research Chinese Academy of Agricultural Sciences College of Bee Sciences Fujian Agriculture and Forestry University

The aim of this work was to distinguish volatile organic compound（VOC） profiles of royal jelly（RJ） from different nectar plants. Headspace solid-phase microextraction（HS-SPME） was used to extract VOCs from raw RJ harvested from 10 nectar plants in flowering seasons. Qualitative and semi-quantitative analysis of VOCs extracts were performed by gas chromatography-mass spectrometry（GC-MS）. Results showed that VOC profiles of RJ from the samples were rich in acid, ester and aldehyde compound classes, however, contents of them were differential, exemplified by the data from acetic acid, benzoic acid methyl ester, hexanoic acid and octanoic acid. As a conclusion, these four VOCs can be used for distinguishing RJ harvested in the seasons of different nectar plants.

关键词： royal jelly volatile organic compounds nectar plant headspace solid-phase microextraction gas chromatography-mass spectrometry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Occupational Asthma Caused by Inhalable royal jelly ancl Its Cross-reactivity with Honeybee Venom

引用

Chinese Medical Journal 2016年第23期129卷 2888-2889页

作者： Li-Sha Li Kai Guan Department of Allergy Peking Union Medical College Hospital Beijing 100730 China

royal jelly is a honeybee nutriment secreted from the glands in the hypopharynx of worker bees essential in the development of queen bees. Ingestion of royal jelly has been reporied to trigger rhinitis, asthma, and an... 详细信息

关键词： Bee Venom Cross-reactivity Occupational Asthma royal jelly

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

royal jelly for genitourinary syndrome of menopause:A randomized controlled trial

引用

Gynecology and Obstetrics Clinical Medicine 2021年第4期1卷 211-215页

作者： Vahid Mehrnoush Fatemeh Darsareh Urology Department Northern Ontario School of MedicineThunder BayOntarioCanada Mother and Child Welfare Research Center Hormozgan University of Medical SciencesBandar AbbasIran

Objective:Genitourinary syndrome of menopause is a progressive condition characterized by a decrease in estrogen,which causes bothersome genital symptoms.The purpose of the study was to determine the effect of royal jelly on the genitourinary syndrome of menopause.Materials and methods:A randomized controlled trial was carried out from November 2018 to June 2019 in Bandar Abbas,Iran.The trial was registered in the Iranian Registry of Clinical Trials(1RCT20181107041585N1)with the main objective of determining if royal jelly could reduce the genitourinary syndrome of menopausal women.Eligible women were randomly assigned to receive either daily 1g of oral royal jelly or placebo for 8 weeks.The urogenital subscale of the Menopausal Rating Scale was used to determine genitourinary syndrome.Independent samples t-test was used for inter-group comparisons and paired samples t-test for pre-and post-treatment comparisons.Results:There were no differences in the severity of sexual problems,bladder complications,or vaginal dryness between groups before intervention.Although the intervention group's bladder complications improved slightly after eight weeks of royal jelly treatment compared to the control group(p?0.04),there were no significant changes in vaginal dryness,sexual problems,or total urogenital score.The within-group changes(before and after treatment)also showed no differences in urogenital symptoms.Conclusions:A daily dose of 1g royal jelly taken orally for 8 weeks did not alleviate menopausal genitourinary syndrome.No serious side effects were observed.To make more reliable decisions about the use and safety of royal jelly in the future,different doses of royal jelly and longer trials are required.

关键词： Genitourinary syndrome royal jelly Menopause Menopausal rating scale

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of royal jelly on in vitro fertilization and early embryo development following nicotine treatment in adult female rats

引用

Asian pacific Journal of Reproduction 2021年第3期10卷 121-126页

作者： Zhila Khodabandeh Vahid Nejati Ali Shalizar-Jalali Gholamreza Najafi Fatemeh Rahmani Department of Biology Faculty of ScienceUrmia UniversityUrmiaIran Department of Veterinary Basic Sciences Faculty of Veterinary MedicineUrmia UniversityUrmiaIran

Objective:To scrutinize the protective role of royal jelly as an antioxidant on nicotine-induced changes in malondialdehyde(MDA)level,p53 expression,in vitro fertilization(IVF)rate,and early embryo development in adult female rats.Methods:A total of 56 adult female Wistar rats were divided into 8 groups(n=7 in each group).Group 1 served as an untreated control group,group 2,3 and 4 received nicotine at a dose of 0.50,1.00 and 2.00 mg/kg respectively,group 5 received royal jelly at a dose of 100.00 mg/kg,and group 6,7 and 8 received 0.50,1.00 and 2.00 mg/kg nicotine,respectively,with 100.00 mg/kg body weight royal jelly.Nicotine and royal jelly were administered daily for 49 days in the experimental groups intra-peritoneally and orally,respectively.At the end of the experimental period,p53 expression,IVF rate and early embryo development as well as MDA concentration were measured.Results:The IVF rate,number of cumulus oocytes,two-cell embryos and blastocysts decreased in the nicotine-treated groups in a dose-dependent manner.In addition,p53 mRNA expression and MDA levels increased in the nicotine-treated groups.royal jelly co-administration led to partial improvement in the aforementioned parameters.Conclusions:royal jelly may have a repro-protective effect in nicotine-administered female rats in terms of its anti-oxidant and anti-apoptotic properties.

关键词： Fertility Nicotine Ovary Rat royal jelly In vitro fertilization Embryo development

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thymoquinone anticancer activity is enhanced when combined with royal jelly in human breast cancer

引用

World Journal of Clinical Oncology 2021年第5期12卷 342-354页

作者： Maya M Moubarak Nour Chanouha Najwa Abou Ibrahim Hala Khalife Hala Gali-Muhtasib Department of Biology American University of BeirutBeirut 1107-2020Lebanon Rammal Rammal Laboratory(ATAC group) Faculty of Sciences IHadath 1003Lebanon Department of Biology and Center for Drug Discovery American University of BeirutBeirut 1107-2020Lebanon

BACKGROUND Breast cancer is the most common cause of the majority of cancer-related deaths in women,among which triple-negative breast cancer is the most aggressive type of breast cancer diagnosed with limited treatment options.Thymoquinone(TQ),the main bioactive constituent of Nigella sativa,has been extensively studied as a potent anticancer molecule against various types of cancers.Honeybee products such as the royal jelly(RJ),the nutritive secretion fed to honeybee queens,exhibit a variety of biological activities besides its anticancer effect.However,the anticancer activity of the combination of TQ and RJ against breast cancer is still unknown.AIM To investigate cytotoxicity of RJ in FHs 74 Int cells and the anticancer effects of TQ,RJ,and their combinations in the MDA-MB-231 cell line.METHODS Cells were treated with TQ,RJ,and their combinations for 24 h.Using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,we determined the half-maximal inhibitory concentration of TQ.Trypan blue and 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays were then performed to assess the cell viability in response to different treatment conditions.Cell death and cycle regulation were investigated using propidium iodide deoxyribonucleic acid staining followed by flow cytometry in response to a single dose of TQ,RJ,and their combination.Immunostaining for cleaved caspase 3 and Ki67 expression was used to determine apoptosis induction and changes in cell proliferation.RESULTS TQ alone inhibited cell viability in a dose-dependent manner at concentrations below and above the half-maximal inhibitory concentration.RJ exhibited relatively nontoxic effects against MDA-MB-231 cells and FHs 74 Int small intestinal cells at concentrations below 5μg/mL.High doses of RJ(200μg/mL)had greater toxicity against MDA-MB-231 cells.Interestingly,the inhibition of cell viability was most pronounced in response to 15μmol/L TQ and 5μg/mL RJ.A dose of 15μmol/L TQ caused a significant increase in the PreG1 population,wh

关键词： Anticancer activity Breast cancer cells Drug combination Natural products royal jelly Thymoquinone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

royal jelly Reduces Cholesterol Levels, Ameliorates Aβ Pathology and Enhances Neuronal Metabolic Activities in a Rabbit Model of Alzheimer's Disease

Royal Jelly Reduces Cholesterol Levels, Ameliorates Aβ Path...

引用

第十四届中国实验动物科学年会

作者： YongmingPan JianqinXu Cheng Chen FangmingChen Ping Jin KeyanZhu Chenyue W.Hu Mengmeng You MinliChen Fuliang Hu College of Animal Sciences Zhejiang University Comparative medical Research Center Experimental Animal Research Center Zhejiang Chinese Medical University The First Affiliated Hospital Zhejiang Chinese Medical University Department of Bioengineering Rice University

Alzheimer’s disease(AD) is the most common form of dementia characterized by aggregation of amyloid β(Aβ) and neuronal loss. One of the risk factors for AD is high cholesterol levels,which are known to promote Aβ deposition.Previous studies have shown that royal jelly(RJ), a product of worker bees, has potential neuroprotective effects and can attenuate Aβ toxicity.However, little is known about how RJ regulates Aβ formation and its effects on cholesterol levelsand neuronal metabolic activities.Here,we investigated whether RJ can reduce cholesterol levels, regulate Aβ levels and enhance neuronal metabolic activitiesin an AD rabbit model induced by 2% cholesterol diet plus copper drinking water.Our results suggest that RJ significantly reduced the levels of plasma total cholesterol(TC) and low density lipoprotein-cholesterol(LDL-C),anddecreased the level of Aβ in rabbit brains. RJ was also shown to markedly ameliorate amyloid deposition in AD rabbits from Aβ immunohistochemistry and thioflavin-T staining.Furthermore, our study suggests that RJ can reduce the expression levelsofβ-site APP cleaving enzyme-1(BACE1) andreceptor for advanced glycation end products(RAGE),and increasethe expression levels of low density lipoprotein receptor-related protein(LRP-1) and insulin degrading enzyme(IDE).In addition, we found that RJ remarkablyincreased the number of neurons, enhanced antioxidant capacities, inhibited activated-capase-3 protein expression, and enhanced neuronal metabolic activities by increasing N-acetyl aspartate(NAA)and glutamate and by reducing choline and myo-inositolin AD rabbits. Taken together, our data demonstrated that RJ couldreduce cholesterol levels, regulate Aβ levels and enhance neuronal metabolic activities in AD rabbits, providing preclinical evidence that RJ treatment has the potential toprotectneuronsand prevent AD.

关键词： royal jelly Alzheimer’s disease hypercholesterolemia amyloid plaques neuronal metabolism activity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：