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The endogenous antioxidant ability of royal jelly in Drosophila is independent of Keap1/Nrf2 by activating oxidoreductase activity

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Insect Science 2024年第2期31卷 503-523页

作者： Dongjing Wen Jiayu Xie Yao Yuan Lirong Shen Yufeng Yang Wenfeng Chen Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouChina School of Medicine Chongqing UniversityChongqingChina College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhouChina

royal jelly(RJ)is a biologically active substance secreted by the hypopharyngeal and mandibular glands of worker *** is widely claimed that RJ reduces oxidative ***,the antioxidant activity of RJ has mostly been determined by in vitro chemical detection methods or by external administration drugs that cause oxidative *** RJ can clear the endogenous production of reactive oxygen species(ROS)in cells remains largely ***,we systematically investigated the antioxidant properties of RJ using several endogenous oxidative stress models of *** found that RJ enhanced sleep quality of aging Drosophila,which is decreased due to an increase of oxidative damage with *** supplementation improved survival and suppressed ROS levels in gut cells of flies upon exposure to hydrogen peroxide or to the neurotoxic agent ***,RJ supplementation moderated levels of ROS in endogenous gut cells and extended lifespan after exposure of flies to heat *** deprivation leads to accumulation of ROS in the gut cells,and RJ attenuated the consequences of oxidative stress caused by sleep loss and prolonged ***,RJ prevented cell oxidative damage caused by heat stress or sleep deprivation,with the antioxidant activity in vivo independent of Keap1/Nrf2 *** supplementation activated oxidoreductase activity in the guts of flies,suggesting its ability to inhibit endogenous oxidative stress and maintain health,possibly in humans.

关键词： antioxidant biological oxidations Drosophila oxidative stress royal jelly sleep loss

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Differential volatile organic compounds in royal jelly associated with different nectar plants

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Journal of Integrative Agriculture 2016年第5期15卷 1157-1165页

作者： ZHAO Ya-zhou LI Zhi-guo TIAN Wen-li FANG Xiao-ming SU Song-kun PENG Wen-jun Institute of Apicultural Research Chinese Academy of Agricultural Sciences College of Bee Sciences Fujian Agriculture and Forestry University

The aim of this work was to distinguish volatile organic compound（VOC） profiles of royal jelly（RJ） from different nectar plants. Headspace solid-phase microextraction（HS-SPME） was used to extract VOCs from raw RJ harvested from 10 nectar plants in flowering seasons. Qualitative and semi-quantitative analysis of VOCs extracts were performed by gas chromatography-mass spectrometry（GC-MS）. Results showed that VOC profiles of RJ from the samples were rich in acid, ester and aldehyde compound classes, however, contents of them were differential, exemplified by the data from acetic acid, benzoic acid methyl ester, hexanoic acid and octanoic acid. As a conclusion, these four VOCs can be used for distinguishing RJ harvested in the seasons of different nectar plants.

关键词： royal jelly volatile organic compounds nectar plant headspace solid-phase microextraction gas chromatography-mass spectrometry

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royal jelly for genitourinary syndrome of menopause:A randomized controlled trial

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Gynecology and Obstetrics Clinical Medicine 2021年第4期1卷 211-215页

作者： Vahid Mehrnoush Fatemeh Darsareh Urology Department Northern Ontario School of MedicineThunder BayOntarioCanada Mother and Child Welfare Research Center Hormozgan University of Medical SciencesBandar AbbasIran

Objective:Genitourinary syndrome of menopause is a progressive condition characterized by a decrease in estrogen,which causes bothersome genital *** purpose of the study was to determine the effect of royal jelly on the genitourinary syndrome of *** and methods:A randomized controlled trial was carried out from November 2018 to June 2019 in Bandar Abbas,*** trial was registered in the Iranian Registry of Clinical Trials(1RCT20181107041585N1)with the main objective of determining if royal jelly could reduce the genitourinary syndrome of menopausal *** women were randomly assigned to receive either daily 1g of oral royal jelly or placebo for 8 *** urogenital subscale of the Menopausal Rating Scale was used to determine genitourinary *** samples t-test was used for inter-group comparisons and paired samples t-test for pre-and post-treatment ***:There were no differences in the severity of sexual problems,bladder complications,or vaginal dryness between groups before *** the intervention group's bladder complications improved slightly after eight weeks of royal jelly treatment compared to the control group(p?0.04),there were no significant changes in vaginal dryness,sexual problems,or total urogenital *** within-group changes(before and after treatment)also showed no differences in urogenital ***:A daily dose of 1g royal jelly taken orally for 8 weeks did not alleviate menopausal genitourinary *** serious side effects were *** make more reliable decisions about the use and safety of royal jelly in the future,different doses of royal jelly and longer trials are required.

关键词： Genitourinary syndrome royal jelly Menopause Menopausal rating scale

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Effect of royal jelly on in vitro fertilization and early embryo development following nicotine treatment in adult female rats

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Asian pacific Journal of Reproduction 2021年第3期10卷 121-126页

作者： Zhila Khodabandeh Vahid Nejati Ali Shalizar-Jalali Gholamreza Najafi Fatemeh Rahmani Department of Biology Faculty of ScienceUrmia UniversityUrmiaIran Department of Veterinary Basic Sciences Faculty of Veterinary MedicineUrmia UniversityUrmiaIran

Objective:To scrutinize the protective role of royal jelly as an antioxidant on nicotine-induced changes in malondialdehyde(MDA)level,p53 expression,in vitro fertilization(IVF)rate,and early embryo development in adult female ***:A total of 56 adult female Wistar rats were divided into 8 groups(n=7 in each group).Group 1 served as an untreated control group,group 2,3 and 4 received nicotine at a dose of 0.50,1.00 and 2.00 mg/kg respectively,group 5 received royal jelly at a dose of 100.00 mg/kg,and group 6,7 and 8 received 0.50,1.00 and 2.00 mg/kg nicotine,respectively,with 100.00 mg/kg body weight royal *** and royal jelly were administered daily for 49 days in the experimental groups intra-peritoneally and orally,*** the end of the experimental period,p53 expression,IVF rate and early embryo development as well as MDA concentration were ***:The IVF rate,number of cumulus oocytes,two-cell embryos and blastocysts decreased in the nicotine-treated groups in a dose-dependent *** addition,p53 mRNA expression and MDA levels increased in the nicotine-treated *** jelly co-administration led to partial improvement in the aforementioned ***:royal jelly may have a repro-protective effect in nicotine-administered female rats in terms of its anti-oxidant and anti-apoptotic properties.

关键词： Fertility Nicotine Ovary Rat royal jelly In vitro fertilization Embryo development

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royal jelly Extract Accelerates Keratinocyte Proliferation, and Upregulates Laminin α3 and Integrin β1 mRNA Expression, via Akt/mTOR/HIF-1α Pathway

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Journal of Cosmetics, Dermatological Sciences and Applications 2022年第2期12卷 83-94页

作者： Akihiro Aioi Septem-Soken Osaka Japan

Background: In the previous decade, various benefits and biological activities of royal jelly, applied in alternative and modern medicine, and cosmetics, have been reported. However, the effects of royal jelly extract (RJ) on keratinocytes have not been fully elucidated. Objective: The primary objectives of this study were to reveal the effects of RJ on keratinocytes and explore the underlying mechanism. Methods: HaCaT cells, an immortal human epidermis-derived keratinocyte cell line, were used in this study. Laminin α3 (LAMA3), integrin β1 (ITGB1), and hypoxia-inducible factor-1α (HIF-1α) mRNA expression levels were determined using real-time PCR. Cell proliferation rate was measured using a bromodeoxyuridine uptake assay. Results: RJ treatment upregulated LAMA3, ITGB1 and HIF-1α mRNA expression, and accelerated HaCaT cell proliferation. Akt and mTOR inhibitors suppressed the RJ-induced HIF-1α expression and cell proliferation. HIF-1α silencing abrogated RJ-induced LAMA3 and ITGB1 mRNA expression and cell proliferation, whereas LAMA3 silencing and antibody-mediated ITGB1 blockade did not affect the effects of RJ. Conclusion: RJ upregulates LAMA3 and ITGB1 mRNA expression levels by HIF-1α expression enhancement. In addition, RJ accelerates keratinocyte proliferation via Akt/mTOR/HIF-1α/NF-κB signaling pathway. These suggest that RJ is beneficial for anti-aging, as a skin care product ingredient.

关键词： royal jelly Keratinocyte Proliferation Epidermal Basement Membrane Hypoxia-Inducible Factor-1

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Determination of royal jelly freshness by ELISA with a highly specific anti-apalbumin 1,major royal jelly protein 1 antibody

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第2期16卷 155-166页

作者： Li-rong SHEN Yi-ran WANG Liang ZHAI Wen-xiu ZHOU Liang-liang TAN Mei-lu LI Dan-dan LIU Fa XIAO Zhejiang Key Laboratory for Agro-Food Processing Fuli Institute of Food Science Department of Food Science and NutritionZhejiang University

Major royal jelly protein 1（MRJP1）, designated apalbumin 1, has been regarded as a freshness marker of royal jelly（RJ）. A MRJP1-specific peptide（IKEALPHVPIFD） identified by bioinformatics analysis of homologous members of the major royal protein family was synthesized and used to raise polyclonal anti-MRJP1 antibody（antiSP-MRJP1 antibody）. Western blot analysis showed that anti-SP-MRJP1 antibody only reacted with MRJP1 in RJ. In contrast, the previously reported antibody against recombinant MRJP1（anti-R-MRJP1 antibody） reacted with other members of MRJP family in RJ. Enzyme-linked immunosorbent assay（ELISA） using anti-SP-MRJP1 antibody demonstrated that MRJP1 content in RJ stored at 40 °C significantly degraded by 37.3%, 55.9%, 58.0%, 60.6%, 65.7%, 72.7%, and 73.1% at 7, 14, 21, 28, 35, 42, and 49 d, respectively, when compared with MRJP1 content in fresh RJ（0 d）. Optical density analysis of MRJP bands from sodium dodecyl sulfate-polyacrylamide gel electrophoresis（SDS-PAGE） profiles demonstrated that the degradation of MRJP1, MRJP2, MRJP3, and MRJP5 in RJ was strongly and positively correlated with the period of storage（P〈0.0001）. Our results indicated anti-SP-MRJP1 antibody was highly specific for MRJP1, and ELISA using the antibody is a sensitive and easy-to-use method to determine the freshness and authenticity of RJ.

关键词： Freshness royal jelly Major royal jelly protein 1(MRJP1) Enzyme-linked immunosorbent assay(ELISA) High specific antibody

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Effects of royal jelly Supplementation on Glycemic Control and Oxidative Stress Factors in Type 2 Diabetic Female:A Randomized Clinical Trial

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Chinese Journal of Integrative Medicine 2014年第5期20卷 347-352页

作者： Samira Pourmoradian Reza Mahdavi Majid Mobasseri Elnaz Faramarzi Mehrnoosh Mobasseri Nutrition Research Center Tabriz University of Medical SciencesTabrizIran Endocrinology Department of Medicine Faculty Tabriz University of Medical SciencesTabrizIran Student Research Committee Faculty of NutritionTabriz University of Medical SciencesTabrizIran Faculty of Medicine Tabriz University of Medical SciencesTabrizIran

Objective： It has been proposed that royal jelly has antioxidant properties and may improve oxidative stress and glycemic control. Therefore, we investigated the effects of royal jelly supplementation in diabetic females. Methods： In this pilot, parallel design randomized clinical trial, 50 female volunteers with type 2 diabetes were randomly allocated to the supplemented （25, cases） and placebo （25, cases） groups, based on random block procedure produced by Random Allocation Software, given a daily dose of 1,000 mg royal jelly soft gel or placebo, respectively, for 8 weeks. Before and after intervention, glycemic control indices, antioxidant and oxidative stress factors were measured. Results： After royal jelly supplementation, the mean fasting blood glucose decreased remarkably （163.05_± 42.51 mg/dL vs. 149.68 ± 42.7 mg/dL）. royal jelly supplementation resulted in significant reduction in the mean serum glycosylated hemoglobin levels （8.67%± 2.24% vs. 7.05% ± 1.45%, P=0.001） and significant elevation in the mean insulin concentration （70.28 ± 29.16 pmol/L vs. 86.46± 27.50 pmol/L, P=0.01）. Supplementation significantly increased erythrocyte superoxidase dismutase and glutathione peroxidase activities and decreased malondialdehyde levels （P〈0.05）. At the end of study, the mean total antioxidant capacity elevated insignificantly in both groups. Conclusions： On the basis of our findings, it seems that royal jelly supplementation may be beneficial in controlling diabetes outcomes. Further studies with larger sample size are warranted.

关键词： glycemic control oxidative stress royal jelly type 2 diabetes

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Occupational Asthma Caused by Inhalable royal jelly ancl Its Cross-reactivity with Honeybee Venom

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Chinese Medical Journal 2016年第23期129卷 2888-2889页

作者： Li-Sha Li Kai Guan Department of Allergy Peking Union Medical College Hospital Beijing 100730 China

royal jelly is a honeybee nutriment secreted from the glands in the hypopharynx of worker bees essential in the development of queen bees. Ingestion of royal jelly has been reporied to trigger rhinitis, asthma, and an... 详细信息

关键词： Bee Venom Cross-reactivity Occupational Asthma royal jelly

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royal jelly Reduces Cholesterol Levels, Ameliorates Aβ Pathology and Enhances Neuronal Metabolic Activities in a Rabbit Model of Alzheimer's Disease

Royal Jelly Reduces Cholesterol Levels, Ameliorates Aβ Path...

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第十四届中国实验动物科学年会

作者： YongmingPan JianqinXu Cheng Chen FangmingChen Ping Jin KeyanZhu Chenyue W.Hu Mengmeng You MinliChen Fuliang Hu College of Animal Sciences Zhejiang University Comparative medical Research Center Experimental Animal Research Center Zhejiang Chinese Medical University The First Affiliated Hospital Zhejiang Chinese Medical University Department of Bioengineering Rice University

Alzheimer’s disease(AD) is the most common form of dementia characterized by aggregation of amyloid β(Aβ) and neuronal loss. One of the risk factors for AD is high cholesterol levels,which are known to promote Aβ *** studies have shown that royal jelly(RJ), a product of worker bees, has potential neuroprotective effects and can attenuate Aβ ***, little is known about how RJ regulates Aβ formation and its effects on cholesterol levelsand neuronal metabolic ***,we investigated whether RJ can reduce cholesterol levels, regulate Aβ levels and enhance neuronal metabolic activitiesin an AD rabbit model induced by 2% cholesterol diet plus copper drinking *** results suggest that RJ significantly reduced the levels of plasma total cholesterol(TC) and low density lipoprotein-cholesterol(LDL-C),anddecreased the level of Aβ in rabbit brains. RJ was also shown to markedly ameliorate amyloid deposition in AD rabbits from Aβ immunohistochemistry and thioflavin-T ***, our study suggests that RJ can reduce the expression levelsofβ-site APP cleaving enzyme-1(BACE1) andreceptor for advanced glycation end products(RAGE),and increasethe expression levels of low density lipoprotein receptor-related protein(LRP-1) and insulin degrading enzyme(IDE).In addition, we found that RJ remarkablyincreased the number of neurons, enhanced antioxidant capacities, inhibited activated-capase-3 protein expression, and enhanced neuronal metabolic activities by increasing N-acetyl aspartate(NAA)and glutamate and by reducing choline and myo-inositolin AD rabbits. Taken together, our data demonstrated that RJ couldreduce cholesterol levels, regulate Aβ levels and enhance neuronal metabolic activities in AD rabbits, providing preclinical evidence that RJ treatment has the potential toprotectneuronsand prevent AD.

关键词： royal jelly Alzheimer’s disease hypercholesterolemia amyloid plaques neuronal metabolism activity

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royal jelly decrease the impairment of learning and memory in the APP/PS1 transgenic mice model

Royal Jelly decrease the impairment of learning and memory i...

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中国神经科学学会第十二届全国学术会议

作者： Hou-yun Chen Qin-lan Xu An-Chen Guo Qun Wang China National Clinical Research Center for Neurological Diseases Center of Stroke Beijing Institute for Brain Disorders Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease Department of Chinese Medicine Beijing City University Department of Neurology Beijing Tiantan HospitalCapital Medical University Laboratory of Clinical Medical Research Beijing Tian Tan Hospital Capital Medical University

Objective: Alzheimer’s disease is a degenerative disease of the nervous system that is associated with impairment of learning and memory. Pathological features of neurofilament tangles, amyloid β（Aβ） accumulation. royal jelly is an essential food for the honey bee young larva and the queen herself, play important nutritional roles in the queen. royal jelly enhance memory, improve the body’s nervous system function. The research was to investigate the effects of royal jelly on spatial learning and memory of AD mice. Methods: 85, male, 3-month old APP/PS1 mice were administered with 0.2 ml;0.4 ml;0.8 ml of royal jelly for 4 weeks, then spatial learning and memory was tested once a week by Morris Water Maze Test. And at the end of experiment, part of animals were sacrificed and the brains were removed and saved in-80 oC fridge for biochemical test. And the other animals were perfused with 4% polyformaldehyde for histological research. Results: Compared with the sham group, the mice model of APP/PS1 Alzheimer’s disease significantly led to learning and memory deficiencies. Transgenic group latency and path length were increased. Less remembered the target quadrant that previously the platform was located. royal jelly can decrease the latency and path length of the animal. Histologically, royal jelly can decrease the tangles of Abeta. Conclusion: royal jelly plays the prevention function on the impairment of learning and memory for the prevention and/or treatment of AD.

关键词： royal jelly Alzheimer’s disease APP/PS1 transgenic model

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