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Improvement of Quality of Nonanesthetic colonoscopy by Preoperative Administration of Pinaverium Bromide

Chinese Medical Journal 2017年第6期130卷 631-635页

作者： Xiao-Lin Wang Jian-Ning Zhou Li Ren Xiao-Li Pan Hong-Yu Ren Jun Liu Division of Gastroenterology Liyuan Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430077 China Division of Gastroenterology Wuhan Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Huhei 430022 China Division of Pharmacy Zaoyang First People's Hospital Zaoyang Hubei 441200 China

Background： Nonanesthetic colonoscopy is popular in clinical practice in China. However, intestinal spasms often result in a prolonged examination time, increased operating difficulties, decreased polyp detection rate, and failure to complete the procedure clinically. Therefore, exploring alternative approaches that can reduce the pain in patients during colonoscopy is of utmost importance, and finding the optimal preoperative administration to improve the quality of nonanesthetic colonoscopy is also necessary. This study aimed to investigate the effects of the prophylactic administration of pinaverium bromide before colonoscopy and the effects of pinaverium bromide alone at different time points or combined with scopolamine butylbromide. Methods： A randomized controlled trial was performed on a cohort of 1000 patients who underwent colonoscopy in outpatient clinic of Wuhan Union Hospital. The patients were randomly assigned to the following groups： Group A, given oral pinaverium bromide （100 mg, three times a day） one day before examination combined with intramuscular injection of scopolamine butylbromide （20 mg） 10 min before colonoscopy; Group B0, given pinaverium bromide alone on the day ofcolonoscopy （ 100 mg, three times a day）; Group B1, given pinaverium bromide alone （100 mg, three times a day） one day before colonoscopy; Group B2, given pinaverium bromide alone （100 mg, three times a day） two days before colonoscopy; and Group C, given scopolamine butylbromide alone （20 mg） before colonoscopy. The successful rate of colonoscopy, procedure time, degree of abdominal pain, and polyp detection rate were recorded and compared among all groups. Results： The successful rate of colonoscopy in Group B1 （82.0%） and Group B2 （83.0%） was significantly higher than that in Group B1 （62.0%, all P 〈 0.01 ）. The time to reach the ileocecal region in Group B1 and Group B, were lower than those in Group B0 （all P 〈 0.05）. However, no significant differences were observed in p

关键词： Abdominal Pain Pinaverium Bromide routine colonoscopy

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