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rosai-dorfman disease of lung： a case report and review of the literatures

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Chinese Medical Journal 2009年第7期122卷 873-874页

作者： SHI Su-sheng SUN Yun-tian GUO Lei Department of Pathology Cancer Institute (Hospital) Chinese Academy of Medical Science & Peking Union Medical College Beijing 100021 China

rosai-dorfman disease （RDD）, also known as sinus histiocytosis with massive lymphadenopathy （SHML）, is a rare benign entity of unknown etiology. Extranodal SHML （ESHML） may occur as part of a generalized process involving lymph nodes or may involve extranodal sites independent of the lymph node status. Here we report a case with a rosai-dorfman disease of the lung and review the literature.

关键词： rosai-dorfman disease histiocytosis, sinus lung

A Study on Clinical Characteristics and Magnetic Resonance Imaging Manifestations on Systemic rosai-dorfman disease

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Chinese Medical Journal 2018年第4期131卷 440-447页

作者： Xiao Cheng Jing-Liang Cheng An-Kang Gao Department of Magnetic Resonance Imaging The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450000 China

Background： rosai-dorfman disease （RDD） is typically characterized by painless bilateral and symmetrical cervical lymphadenopathy, with associated fever and leukocytosis. The aim of the current study was to summarize the clinical features and imaging characteristics of RDD, in an effort to improve its diagnostic accuracy. Methods： The study was analyzed from 32 patients between January 2011 and December 2017; of these, 16 patients had pathologically diagnosed RDD, eight had pathologically diagnosed meningioma, and eight pathologically diagnosed lymphoma. All patients underwent computed tomography and magnetic resonance imaging （MRI）. Clinical features and imaging characteristics of RDD were analyzed retrospectively. The mean apparent diffusion coefficient （ADC） values of lesions at different sites were measured, and one-way analysis of variance and the least significant difference t-test were used to compare the differences between groups and draw receiver operating characteristic curves. The tumors were excised for biopsy and analyzed using immunohistochemistry. Results： The mean ADCs were （0.81 ± 0.10） × 10^-3mm^2/s for intercranial RDD, （0.73 ± 0.05） × 10^-3mm^2/s for nasopharyngeal RDD, （0.74 ± 0.11） × 10^-3mm2/s for bone RDD, and （0.71 ± 0.04） × 10^-3mm2/s for soft-tissue RDD. The optimum ADC to distinguish intracranial RDD from lymphoma was 0.79 × 10^-3mm2/s （62.5% sensitivity and 100% specificity） and to distinguish meningioma from intracranial RDD was 0.92 × 10^-3mm^2/s （62.5% sensitivity and 100% specificity）. Levels of C-reactive protein, erythrocyte sediment rate and D-dimer were significantly elevated （81%, 87%, and 75%, respectively）. On immunohistochemistry, RDD was positive for both S-100 and CD68 proteins but negative for CD1a. Conclusions： Conventional MRI, combined with diffusion-weighted imaging and ADC mapping, is an important diagnostic tool in evaluating RDD patients. An accurate diagnosis of RDD should consider the clinical features, imaging c

关键词： Apparent Diffusion Coefficient Clinical Feature Imaging Manifestation Magnetic Resonance Imaging rosai-dorfman disease

Cutaneous rosai-dorfman disease presenting as a granulomatous rosacea-like rashs

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Chinese Medical Journal 2011年第5期124卷 793-794页

作者： SHI Xiu-yan MA Dong-lai FANG Kai Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

A case of cutaneous rosai-dorfman disease （CRDD） presenting as a granulomatous rosacea-like rashs was reported. A 45-year-old Chinese woman presented with a 1-month history of a widespread nonpruiginous papulonodular eruption. The rash had begun on her face and rapidly progressed to involve the neck and extremities. She was otherwise healthy, with no history of fever, malaise, or weight loss. Physical examination revealed multiple symmetrically distributed discrete and coalescing red plaques, papules and nodules scattered over the face, neck and extremities. No appreciable lymphadenopathy or hepatosplenomegaly was noted. There was no mucosal involvement. The biopsy specimen obtained from the face demonstrated the epidermis was normal, while the superficial dermis contained sheets of histiocytes with abundant, focally foamy cytoplasm. The histiocytes were surrounded by a patchy lymphocytic and plasma cell infiltrate. There was no significant histiocytic atypia. Some of these histiocytes engulfed, without destroying, lymphocytes and neutrophils （emperipolesis）. Immunohistochemical staining revealed that the histiocytes were strongly positive for S100 protein, weakly positive for CD68, and negative for CDla. A diagnosis of CRDD was made. Oral prednisone therapy was initiated at a dosage of 30 mg/d for 3 weeks and then tapered over the ensuing 2 weeks. After 5 weeks of treatment, the lesions had markedly improved.

关键词： rosai-dorfman disease sinus histiocytosis with massive lymphadenopathy skin granulomatous rosacea

Staging surgery for intraventricular bilateral giant rosai–dorfman disease in children

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Pediatric Investigation 2022年第1期6卷 50-54页

作者： Jiyin Zhang Dapeng Li Ran Cheng Nan Zhang Xin Ni Ming Ge Department of Otolaryngology Head and Neck SurgeryBeijing Children’s HospitalCapitalMedical UniversityNational Center for Children’s HealthBeijingChina Department of Neurosurgery Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Emergency Surgery Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Pathology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Introduction:rosai-dorfman disease(RDD)is an uncommon,benign,and idiopathic histiocytic proliferative *** intracranial RDD is extremely rare and treatment *** presentation:A 9-year-old girl was admitted with 3-month history of blurred vision and facial paralysis,a 2-month history of recurrent giggle,and cognitive *** tomography and magnetic resonance imaging scans revealed bilateral ventricular masses based on the dural membrane and the diameters of the masses were 9.1 cm and 9.2 cm,*** lesions were completely removed with staging *** months after operation,blurred vision was still present but facial paralysis and giggle and cognitive impairment *** examinations suggested that there were no new or recurring ***:For multiple large intracranial masses,surgical treatment is necessary and staged surgery benefits perioperative *** follow-up with magnetic resonance imaging is necessary.

关键词： Intraventricular Pediatric rosai-dorfman disease Sinus histiocytosis Staging surgery

Isolated intradural rosai-dorfman disease of the spine:report of two cases

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Chinese Neurosurgical Journal 2016年第2期2卷 -页

作者： Yu Xin Hui Shen Desheng Kong Wenqing Jia Hai Liu Jun Yang People's Republic of China 100050 Equal contributors Department of Neurosurgery Beijing Pinggu Hospital No.59 Xinping North Road Pinggu District Beijing People's Republic of China Equal contributors People's Republic of China. 100050

Background:rosai-dorfman disease (RDD) is an idiopathic histiocytic proliferative disorder characterized by sinus histiocytosis and massive lymphadenopathy. Extranodal and central nervous system (CNS) involvement is unusual. We describe two distinctly rare cases of isolated intradural RDD of the spine without cervical lymphadenopathy. Case presentation:We report our experience in the management of two patients with RDD. The first patient had two ventral intradural lesions, radiologically in favour of multiple spinal meningiomas, and the second patient presented an intradural extramedually lesion, extending into the right foramina, suggestive of a sacral perineural cyst. Treatments consisted of total excision and subtotal excision without steroids and radiotherapy, respectively. The definitive diagnosis was confirmed by histopathology and immunochemistry. Conclusions:RDD should be considered in the rare differential diagnosis of a spinal disease. Resection of the lesions is an effective treatment choice to relieve spinal compression symptoms. The efficacy of the adjuvant therapy to control the disease is unknown.

关键词： rosai-dorfman disease Sinus histiocytosis with massive lymphadenopathy Meningiomas Spinal cord

Submandibular Gland rosai-dorfman disease: A Case Report and Literature Review

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Submandibular Gland Rosai-Dorfman Disease: A Case Report and...

声门下区rosai-dorfman病1例并文献复习

2020年全国口腔颌面-头颈肿瘤学术大会暨中华口腔医学会口腔颌面-头颈肿瘤专业委员会学术年会——创新超越、共赢未来

作者：陈鹏林李嵩福建医科大学附属第一医院

Purpose/Background:rosai dorfman disease(RDD) is a rare, benign histiocytic proliferative condition of unsubstantiated etiology. It can occur in any part of human body. However, lesions occur in the submandibular gland is rarely reported. Herein, we present a rare case of mandibular gland rosai-dorfman disease, and review the literature in order to better understand this kind of disease entity.

关键词： Submandibular Gland rosai-dorfman disease

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临床耳鼻咽喉头颈外科杂志 2024年第8期38卷 755-757页

作者：胡成浩高冯翔张英郭斌青海大学附属医院耳鼻咽喉科青海西宁810001

rosai-dorfman病是一种罕见的非朗格汉斯组织细胞疾病,具有淋巴结内和(或)结外表现。目前尚无治疗这种疾病的指导方案。本文报道1例声门下区的病例,患者未表现出典型的症状,如发烧或淋巴结病,术前极易被误诊为恶性肿瘤。患者接受了低温... 详细信息

rosai-dorfman病是一种罕见的非朗格汉斯组织细胞疾病,具有淋巴结内和(或)结外表现。目前尚无治疗这种疾病的指导方案。本文报道1例声门下区的病例,患者未表现出典型的症状,如发烧或淋巴结病,术前极易被误诊为恶性肿瘤。患者接受了低温等离子微创手术联合激素治疗,获得良好疗效。本文通过对rosai-dorfman病相关文献进行回顾,以便更好地了解此种罕见疾病的临床表现、诊断和治疗。

关键词： rosai-dorfman disease 声门下疾病外科手术

鼻-鼻窦rosai-dorfman病复发因素分析及治疗策略

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鼻-鼻窦Rosai-Dorfman病复发因素分析及治疗策略