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3D-printed NIR-responsive shape memory polyurethane/magnesium scaffolds with tight-contact for robust bone regeneration

引用

Bioactive Materials 2022年第10期7卷 218-231页

作者： Yuanchi Zhang Cairong Li Wei Zhang Junjie Deng Yangyi Nie Xiangfu Du Ling Qin Yuxiao Lai Centre for Translational Medicine Research&Development Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina University of Chinese Academy of Sciences ShenzhenChina Key Laboratory of Health Informatics Chinese Academy of SciencesShenzhenChina Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyThe Chinese University of Hong KongHong Kong SARChina CAS-HK Joint Lab of Biomaterials ShenzhenChina

Patients with bone defects suffer from a high rate of disability and *** contact of grafts with defective bones and insufficient osteogenic activities lead to increased loose risks and unsatisfied repair *** self-expanding scaffolds were developed to enhance bone integration,the limitations on the high transition temperature and the unsatisfied bioactivity hindered greatly their clinical ***,we report a near-infrared-responsive and tight-contacting scaffold that comprises of shape memory polyurethane(SMPU)as the thermal-responsive matrix and magnesium(Mg)as the photothermal and bioactive component,which fabricated by the low temperature rapid prototyping(LT-RP)3D printing *** designed,due to synergistic effects of the components and the fabrication approach,the composite scaffold possesses a homogeneously porous structure,significantly improved mechanical properties and stable photothermal *** programmed scaffold can be heated to recover under near infrared irradiation in *** 4 wt%Mg,the scaffold has the balanced shape fixity ratio of 93.6%and shape recovery ratio of 95.4%.The compressed composite scaffold could lift a 100 g weight under NIR light,which was more than 1700 times of its own *** results of the push-out tests and the finite element analysis(FEA)confirmed the tight-contacting ability of the SMPU/4 wt%Mg scaffold,which had a signficant enhancement compared to the scaffold without shape memory ***,The osteopromotive function of the scaffold has been demonstrated through a series of in vitro and in vivo *** envision this scaffold can be a clinically effective strategy for robust bone regeneration.

关键词： Shape memory polyurethane Magnesium 3D printing robust bone regeneration Tight-contact

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