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Influence of artificial luminous environment and TCM intervention on development of myopia rabbits

Asian Pacific Journal of Tropical Medicine 2015年第3期8卷 243-248页

作者： Yan Liu Yu-Liang Wang Ke-Lei Wang Fang Liu Xia Zong Department of Ophthalmology Nanjing University of Chinese Medicine Department of Ophthalmology.Jiangsu Province Hospital of TCM Affiliated Hospital of Nanjing University of TCM Department of Ophthalmology Wuxi Hospital of TCM Department of Ophthalmology Shanghai TCM-Integrated HospitalShanghai University of TCM No.1 Clinical Medical College Nanjing Unirersity of Chinese Medicine

Objective:To explore the influence of artificial luminous environment and preventive function of traditional Chinese medicine(TCM) intervention based on "Theory of yin-yang clock" on myopia.Methods:A total of 45 New Zealand young rabbits were randomly divided into 5groups,9 for each group.Control group was exposed in natural light.Fluorescent group and full spectrum group were exposed in fluorescent light and full spectrum light,on which basis fluorescent TCM group and full spectrum TCM group were added with "Rizhong Yinyang Formulas",respectively.Optical parameters were measured and the influence of different lights on the serum and retinal dopamine(DA) levels as well as the retinal histopathological tissues was observed.Results:The spectrum of fluorescent light mainly focused at 420-490 nm with the peak value of wavelength near 450 nm,whereas that of full spectrum was wider(400-800 nm) with the peak value near 600 nm.After 4 and 12 weeks,fluorescent group was evidently lower in serum and retinal DA levels(P0.05).Histopathological observation showed that there was significant difference in pigment epithelium layer,photoreceptor and nerve fiber layer between fluorescent group and control group,but the difference among the test groups was not significant.Conclusions:Fluorescent light has certain influence on retinal histological construction and visual performance.However,TCM intervention may have some degree of protective function on retina.

关键词： Full spectrum Artificial luminous environment Retina Dopamine Visual performance Rizhong Yinyang formulas

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