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risk factors, Clinical Features, Baseline Alanine Aminotransferase and CD4⁺ count of Children with HIV co-infection with Hepatitis B and C at a Tertiary Hospital in Southwest Nigeria

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International Journal of Clinical Medicine 2016年第4期7卷 280-291页

作者： M. O. Durowaye S. K. Ernest I. A. Ojuawo Department of Paediatrics Federal Medical Centre Lokoja Nigeria Department of Paediatrics and Child Health University of Ilorin Ilorin Nigeria

Background: Human immunodeficiency virus and hepatitis B and C viruses are endemic in sub- Saharan African countries including Nigeria. Researchers have studied the burden of co-infection of HIV with hepatitis B and hepatitis C but the risk factors and clinical presentation have not been much addressed especially in children. Methodology: This was a prospective cross sectional study that determined the prevalence, risk factors, clinical features, baseline CD4+ count, CD4+ percentage, and alanine aminotransferase (ALT) of newly diagnosed, HAART na?ve HIV co-infection among children who were managed at a Tertiary Hospital in Ilorin, Nigeria. Result: Of the 60 HIV- infected children recruited, 11.7% had HIV co-infection with HBV or HCV. Children with co-infec- tions (mean age 8.43 ± 2.37 years) were significantly older than their HIV mono-infected counterparts (mean age 5.25 ± 3.96 years) (p = 0.011). There was no significant difference between HIV monoinfection and HIV co-infection with respect to gender (p = 0.758), ethnicity (p = 0.707), religion of parents (p = 0.436), family type (p = 0.184), social class (p = 0.535), previous transfusion (p = 0.053), scarification (p = 0.612), female genital mutilation (p = 0.778), and sharing of clippers (p = 0.806). The mean BMI, immunological staging (p = 0.535), baseline ALT (p = 0.940), and mean baseline CD4+ count (p = 0.928) were comparable. However, the body mass index of HIV co-infec- ted children decreased with age up till age 10 years. conclusion: There were no risk factors, nor clinical features predictive of co-infection identified in this study. co-infection did not negatively impact baseline, CD4+ count and ALT.

关键词： co-infection Hepatitis B Hepatitis C Human Immunodeficiency Virus Acquired Immunodeficiency Syndrome HIV HBV HCV Alanine Aminotransferase ALT Highly Active Antiretroviral Therapy HAART Monoinfection CD4+ risk factors for co-infection Transmission Hepatitis B Surface Antigen HBVsAg

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