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Role of Cannabinoid CB1 Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats

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Chinese Medical Sciences Journal 2023年第1期38卷 29-37页

作者： Kaveh Shahveisi Seyedeh Marziyeh Hadi Hamed Ghazvini Mehdi Khodamoradi Sleep Disorders Research Center Kermanshah University of Medical SciencesKermanshah ***Iran Faculty of Medicine Kermanshah University of Medical SciencesKermanshah ***Iran Psychiatry and Behavioral Sciences Research Center Addiction InstituteMazandaran University of Medical SciencesSari 48175866Iran Department of Neuroscience School of Advanced Technologies in MedicineMazandaran University of Medical SciencesSari 48175866Iran Substance Abuse Prevention Research Center Health InstituteKermanshah University of Medical SciencesKermanshah ***Iran

Objective We aimed to investigate whether antagonism of the cannabinoid CB1 receptor(CB1R)could affect novel object recognition(NOR)memory in chronically rapid eye movement sleep-deprived(RSD)*** The animals were examined for recognition memory following a 7-day chronic partial RSD paradigm using the multiple platform *** CB1R antagonist rimonabant(1 or 3 mg/kg,i.p.)was administered either at one hour prior to the sample phase for acquisition,or immediately after the sample phase for consolidation,or at one hour before the test phase for retrieval of NOR *** the reconsolidation task,rimonabant was administered immediately after the second sample *** The RSD episode impaired acquisition,consolidation,and retrieval,but it did not affect the reconsolidation of NOR *** administration did not affect acquisition,consolidation,and reconsolidation;however,it attenuated impairment of the retrieval of NOR memory induced by chronic *** These findings,along with our previous report,would seem to suggest that RSD may affect different phases of recognition memory based on its ***,it seems that the CB1R may,at least in part,be involved in the adverse effects of chronic RSD on the retrieval,but not in the acquisition,consolidation,and reconsolidation,of NOR memory.

关键词： REM sleep deprivation novel object recognition memory cannabinoid CB1 receptor rimonabant

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Rise and fall of anti-obesity drugs

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World Journal of Diabetes 2011年第2期2卷 19-23页

作者： Bernard MY Cheung Department of Medicine the University of Hong Kong

Although it is not generally a life-threatening disease,obesity is becoming a major health problem *** can be controlled by means of drugs,and,consequently,these are required to be safe as well as *** this paper,we summarize the fate of various drugs that have been introduced for clinical use in the treatment of *** and dexfenfluramine were withdrawn because of heart valve *** suppresses appetite and increases heart rate and blood *** the Sibutramine Cardiovascular OUTcomes trial,an increase in major adverse cardiovascular events prompted its withdrawal in Europe and the United *** is an endocannabinoid receptor antagonist that reduces body weight and ameliorates some cardiovascular risk ***,adverse psychiatric side effects led to its withdrawal as *** is approved in Europe and the United States for the treatment of obesity,but its use is limited by gastrointestinal *** and caffeine are natural ingredients in foods and supplements that may help the person to lose *** the light of several failed attempts,there is a clear need to develop drugs that are effective and safe in the long term in order to successfully combat the phenomenon of obesity.

关键词： Obesity Anti-obesity drugs Sibutramine rimonabant Orlistat

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