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A Comparative Study of the Short-Term Efficacy of Laparoscopic Radical Resection of right-sided colon cancer with Two Different Surgeon Positions and Trocar Placements

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Journal of cancer Therapy 2022年第3期13卷 105-116页

作者： Ziling Zheng Maocai Tang Shouru Zhang Hao Sun Jingkun Shang Department of Gastrointestinal cancer Center Chongqing University Cancer Hospital Chongqing China

Objective: To investigate the short-term efficacy of laparoscopic radical resection of right-sided colon cancer with two different surgeon positions and trocar placements. Methods: The data of 78 patients who underwent laparoscopic radical resection of right-sided colon cancer between January 2018 and August 2019 were retrospectively analysed. The surgical method was selected by the patients. The patients were divided into two groups according to the surgeons’ positioning habits and trocar placements. The group with the lead surgeon standing between the patient’s legs had 35 patients, and the group with the lead surgeon standing at the left side of the patient had 43 patients. The operation time, intraoperative blood loss, postoperative anal gas evacuation time, postoperative urinary catheter indwelling time, postoperative hospital stay, C-reactive protein (CRP) level on the first day after surgery, and postoperative pathological data and complications were compared between the two groups. Results: All patients underwent the laparoscopic radical resection of right-sided colon cancer, none converting to laparotomy. No significant difference (P > 0.05) in intraoperative blood loss (57.6 ± 21.3 ml vs 60.2 ± 35.3 ml), postoperative anal gas evacuation time (3.5 ± 1.1 d vs 3.8 ± 1.3 d), postoperative urinary catheter indwelling time (2.6 ± 1.3 d vs 2.4 ± 1.2 d), postoperative hospital stay (7.1 ± 1.8 d vs 7.5 ± 2.1 d), or CRP level on the first day after surgery (54.7 ± 9.6 mg/L vs 53.9 ± 8.2 mg/L) was detected between the two groups. The operation time was shorter in the group with the lead surgeon standing between the patient’s legs (185.2 ± 25.6 min vs 196.2 ±19.7 min) (P 0.05). No patients died or had anastomotic fistula

关键词： Laparoscopic Radical Resection right-sided colon cancer Surgeon Positions Trocar Placements

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CDK9 promotes the immune escape of right-sided colon cancer by regulating CD39+ Treg cells

CDK9 promotes the immune escape of right-sided colon cancer ...

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第十三届全国免疫学学术大会

作者： Yang Zhan Jiefu Wang Dalu Kong Tianjin Medical University cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of cancer Prevention and Therapy Tianjin's Clinical Research Center for cancer

Cyclin-dependent kinase 9(CDK9) regulates the development of a variety of malignant tumors, but it has not been reported whether it promotes the development of left/right-sided colorectal cancer by regulating the anti-tumor immune function. We found that CDK9 was highly expressed in stage IV colon cancer and lowly expressed in stage II-IIIa. Interestingly, CDK9 expression in the right-sided colon cancer was higher than in the left-sided colon cancer and rectal cancer. High levels of CDK9 significantly inhibited the infiltration of CD8+T cells and shortened the survival of patients. Further, we found that CDK9 promoted a new type of immunosuppressive cell subset, CD39+ γδ Treg, to infiltrate right-sided colon cancer but not left-sided colon cancer and rectal cancer. And CDK9 also promoted CD4+T and CD8+T cells to express CD39. Advanced colon cancer cells can secrete high levels of "free" CDK9, which affect the tumor microenvironment cytokine spectrum and exhibit immunosuppressive function. We also found that recombinant CDK9 promoted colon cancer proliferation.

关键词： right-sided colon cancer CDK9 CD39+ γδ Treg

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Pan-immune-inflammation value as a prognostic biomarker for colon cancer and its variation by primary tumor location

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World Journal of Gastroenterology 2024年第33期30卷 3823-3836页

作者： Qian-Yu Wang Wen-Tao Zhong Yi Xiao Guo-Le Lin Jun-Yang Lu Lai Xu Guan-Nan Zhang Jun-Feng Du Bin Wu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Medical Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND A growing body of research indicates significant differences between left-sided colon cancers(LCC)and right-sided colon cancers(RCC).Pan-immune-inflammation value(PIV)is a systemic immune response marker that can predict the prognosis of patients with colon ***,the specific distinction between PIV of LCC and RCC remains *** To investigate the prognostic and clinical significance of PIV in LCC and RCC *** This multicenter retrospective cohort study included 1510 patients with colon cancer,comprising 801 with LCC and 709 with *** used generalized lifting regression analysis to evaluate the relative impact of PIV on disease-free survival(DFS)in these ***-Meier analysis,as well as univariate and multivariate analyses,were used to examine the risk factors for *** correlation between PIV and the clinical characteristics was statistically analyzed in these *** A total of 1510 patients{872 female patients(58%);median age 63 years[interquartile ranges(IQR):54-71];patients with LCC 801(53%);median follow-up 44.17 months(IQR 29.67-62.32)}were *** was significantly higher in patients with RCC[median(IQR):214.34(121.78-386.72)vs 175.87(111.92-286.84),P227.84)was associated with worse DFS in LCC[PIV-high:Adjusted hazard ratio(aHR)=2.39;95%confidence interval:1.70-3.38;Pcolon cancer biomarker.

关键词： colon cancer Left-sided colon cancer right-sided colon cancer Pan-immune-inflammation value Systemic inflammatory biomarkers Prognosis

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