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rhus longipes (Engl.) infusions improve glucose metabolism and mitigate oxidative biomarkers in ferrous sulfate-induced renal injury

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Asian Pacific Journal of Tropical Biomedicine 2022年第11期12卷 453-465页

作者： Brian K.Beseni Kolawole AOlofinsan Veronica F.Salau Ochuko L.Erukainure Md.Shahidul Islam Department of Biochemistry University of KwaZulu-NatalWestville CampusDurban 4000South Africa Department of Pharmacology University of the Free StateBloemfontein 9300South Africa

Objective:To explore the antioxidant and antidiabetic activities of rhus longipes(***)leaf and stem bark aqueous ***:*** leaf and stem bark infusions were characterized via gas-chromatography mass-spectroscopy(GC-MS)*** vitro antioxidant and carbohydrate and lipid digestive enzyme inhibitory activities of *** infusions were ***,the modulatory effects of *** infusions on intestinal glucose absorption,muscle glucose uptake,and biomarkers of renal oxidative injury were *** docking was performed to determine the binding affinities of the identified compounds from the leaf and stem bark infusions on carbohydrate and lipid digestive ***:GC-MS analysis revealed the presence of several phytocompounds,including palmitoleic acid,octadecanamide,24,25-dihydroxyvitamin D and L-ascorbic *** bark infusion had significantly higher total phenolic contents compared with the leaf infusion,with better DPPH scavenging[IC_(50):(10.50±1.03)μg/mL]and ferric reducing[IC_(50):(9.85±0.32)μg/mL]activities(P<0.05).Both *** infusions at their highest concentrations significantly increased glucose uptake in yeast suspension and rat psoas muscle with marked suppression of glucose absorption in the rat jejunum(P<0.05).With no cytotoxicity on Vero cells,the infusions lowered lipid peroxidation,increased cellular reduced glutathione concentration,and the activities of superoxide dismutase and catalase in renal homogenate treated with FeSO_(4).Conclusions:*** shows antioxidant and antidiabetic activities and could be a potential therapeutic candidate for diabetes.

关键词： Antioxidant Oxidative biomarkers Enzyme inhibition Antidiabetic rhus longipes Searsia longipes

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