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Connective Tissue diseases on the Elderly Population in dakar Hospital Setting

Open Journal of Internal Medicine 2022年第2期12卷 103-111页

作者： Ndao Awa Cheikh Atoumane Faye Amadou diop dia Nafissatou diagne diatou Gueye dia Birame Codou Fall Michel Assane Ndour Mouhamed dieng Maïmouna Sow Abdoulaye Pouye department of Internal Medicine Aristide Le Dantec Hospital Cheikh Anta Diop University Dakar Senegal department of Internal Medicine Regional Hospital of Saint-Louis Gaston Berger University Saint-Louis Senegal department of Internal Medicine DalalJamm Hospital Cheikh Anta Diop University Dakar Senegal department of Internal Medicine Abass Ndao Hospital Cheikh Anta Diop University Dakar Senegal department of Internal Medicine Aristide Le Dantec Hospital Dakar Senegal

Introduction: Immunosenescence contributes to the development of auto-antibodies. However, while the prevalence of some autoantibodies increases with age, the incidence of connective tissue diseases decreases with age. This study aims to determine the clinical and paraclinical characteristics of connective tissue diseases in the elderly population. Materials and Methods: We conducted a retrospective and descriptive study, from March 2010 to March 2021, in the Internal Medicine department of Aristide Le dantec Hospital, including all the medical records of patients followed up for connective tissue disease and whose symptomatology began at an age greater than or equal to 65 years. Epidemiological, clinical, paraclinical, therapeutic and evolutionary data were collected from a pre-established survey form and then processed using SPSS software. Results: Overall, 22 cases were collected out of 275 seen on consultation. They involved 16 women and 6 men, aged between 65 and 85 years with a median of 70 years. The mean duration of the clinical picture was 15.7 months with extremes of 1 and 96 months. The clinical symptoms were joint pain in 21 patients associated with dry eye and mouth syndrome in seven cases and one patient underwent isolated dry eye and mouth syndrome. Joint involvement was deforming in 13 patients. Poor general condition was noted in 20 patients. Biology showed anemia in 14 patients, hyperleukocytosis (2 patients) and thrombocytosis (5 patients). The sedimentation rate (SR) was accelerated in 9 patients and the C-reactive protein (CRP) was positive in 12 patients. Immunology showed a positive Latex test (3 patients/6), Waaler-Rose reaction (8 patients/13), anti-cyclic citrullinated peptides (anti-CCP) antibodies (11 patients/11), anti-nuclear antibodies (2 patients/4). Anti-extractable nuclear antigens (anti-ENA) antibody testing in 4 patients showed positive anti-U1RNP (1 case), anti-SSA and anti-SSB (1 case). Plain X-Rays of the hands, wrists and feet

关键词： Connective Tissue disease Elderly rheumatoïd polyarthritis Sjögren’s Syndrome dakar

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