检索结果-南通市图书馆

Effect of rhei radix et rhizoma and Eupolyphaga Steleophaga on liver protection mechanism based on pharmacokinetics and metabonomics

引用

Chinese Herbal Medicines 2024年第1期16卷 121-131页

作者： Gang Feng Jianli Bi Wenfang Jin Qi Wang Zhaokui Dan Baolei Fan Hubei University of Science and Technology Xianning 437100China The First People’s Hospital of Xianning Xianning 437000China The First People’s Hospital of Tongshan Tongshan 437600China Hubei Provincial Key Laboratory of Radiation Chemistry and Functional Materials Xianning 437100China

Objective:Based on metabonomics technology of high-performance liquid chromatography-mass spectrometry(HPLC-MS/MS)and hydrogen nuclear magnetic resonance spectroscopy(^(1)H NMR),the pharmacokinetic characteristics and therapeutic mechanism of rhei radix et rhizoma(RhRR,Dahuang in Chinese),Eupolyphaga Steleophaga(EuS,Tubiechong in Chinese)combined with RhRR acting on acute liver injury were ***:Models of acute liver injury were established,and the pharmacokinetic methods of five components of RhRR-EuS in rats were found by HPLC-MS/*** liver tissues of different groups of mice were analyzed by ^(1)H NMR spectroscopy combined with multivariate statistical analysis to investigate the metabolomics of RhRR-EuS and ***:Pharmacokinetic results showed there were different levels of bimodal phenomenon in different groups,and the absorption of free anthraquinone in RhRR increased after compatibility with *** addition,the pathological state of acute liver injury in rats can selectively promote the absorption of emodin,chrysophanol,physcion and aloe *** 15 differential metabolites in the liver tissue of acute liver injury mice,it was revealed that RhRR-EuS and RhRR could protect the liver injury by regulating the metabolism of glutamine and glutamic acid,alanine,aspartic acid and glutamic acid,and ***,the regulation of RhRR was weaker than that of ***:For the first time,we studied the pharmacokinetics and metabolomics differences of RhRREuS and RhRR in rats and mice with acute liver injury,in order to provide theoretical reference for clinical treatment of liver disease by DHZCP.

关键词： Dahuang Zhechong Pills Eupolyphaga Steleophaga 1H NMR HPLC-MS/MS metabonomics pharmacokinetics rhei radix et rhizoma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Quantitative Method for Simultaneous Determination of Four Anthraquinones with One Marker in rhei radix et rhizoma

引用

Chinese Herbal Medicines 2012年第2期4卷 157-163页

作者： Jing-jing ZHU[a][b] Zhi-min WANG[a][b] Xin-yu MA[a] Wei-hong FENG[a][b] Qi-wei ZHANG[a][b] Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines Beijing 100700 China

Objective To develop a quantitative method for simultaneously determining multi-components in rhei radix et rhizoma using one chemical reference *** The contents of multi-components were calculated by the UV relative correction factors(RCFs)of chrysophanol,physcion,and rhein to *** The values of RCFs at 274 nm for rhein,chrysophanol,and physcion to emodin were 0.712,0.674,and *** calibration curves were linear over the ranges of 0.02-4.08,0.02-4.12,0.07-12.92,and 0.02-3.68μg/mL for rhein,emodin, chrysophanol,and physcion,*** contents of emodin in 18 samples were determined by the external standard method,and the contents of the other three anthraquinone aglycones were calculated according to their RCFs. Conclusion No significant difference is found in comparison with the classical method,indicating that the RCFs have high reliability within their linear ranges and could be used in quality control of rhei radix et *** quantitative analysis of multi-component with a single marker is especially suitable for herbal medicines containing unstable or hard to be purified components as quality control markers.

关键词： anthraquinone multi-component quantitative analysis quality control rhei radix et rhizoma UV relative correction factor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rapid Determination of Total Content of Five Major Anthraquinones in rhei radix et rhizoma by NIR Spectroscopy

引用

Chinese Herbal Medicines 2017年第3期9卷 250-257页

作者： Hao Zhan Jing Fang Hong-wei Wu Hong-jun Yang Hua Li Zhu-ju Wang Bin Yang Li-ying Tang Mei-hong Fu Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences

Objective To establish a new method with near-infrared（NIR） spectroscopy to determine the total content of emodin, chrysophanol, rhein, aloeemodin, and physcion. NIR was used in this study to provide rapid and nondestructive analysis results. Methods In the first place, HPLC was used to measure the total content of emodin, chrysophanol, rhein, aloe-emodin and physcion in rhei radix et rhizoma（RR） as a reference. In the second place, the spectral regions, regression methods, pretreatment methods, and partial least squares（PLS） factors were compared to increase the feasibility of the model. In the last, the root mean square error of calibration（RMSEC）, root mean square error of cross validation（RMSECV）, root mean square error of prediction（RMSEP）, and correlation coefficient（r） were used as assessment parameters. Results PLS with first derivative pretreatment in the ranges of 4242-5581 cm^（-1）, 5885-6233 cm^（-1） and 6394-7011 cm^（-1） provided the best results. The RMSEC and RMSEP obtained were 0.134 and 0.226 respectively. The according determination coefficients of the quantitative model were 0.99 and 0.94. Conclusion NIR spectroscopy as a quick and nondestructive analytical method may be used to determine the total content of emodin, chrysophanol, rhein, aloeemodin, and physcion for the quality control of RR.

关键词： near-infrared spectroscopy partial least squares quality control rapid determination rhei radix et rhizoma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research Overview of Zhuang Medicine Fumigation Lotions

引用

Medicinal Plant 2024年第1期15卷 35-37页

作者： Bing QING Jiangcun WEI Fangmei LI Xianyi SHI Li LONG Xian PENG Meiyan QIU Wen ZHONG Zujie QIN Guangxi International Zhuang Medical Hospital Nanning 530201China

At present,there is little research on the application of Zhuang medicine fumigation lotions in skin diseases,and there is no research on related preparation processes and quality *** this paper,the characteristics of its formulation and the research progress in skin diseases are reviewed,in order to deepen the understanding of Zhuang medicine fumigation lotions and provide a more detailed theoretical basis for its clinical research,development and application.

关键词： Zhuang medicine fumigation lotions Ilicis Rotundae Cortex Eiliae Herba Polygoni Perfoliati Herba rhei radix et rhizoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：