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Drug therapy: Solamargine and other solasodine rhamnosyl glycosides as anticancer agents

Modern Chemotherapy 2013年第2期2卷 33-49页

作者： Bill E. Cham Australasian Institute of Medical Research Brisbane Australia

In the last century, the discovery of cytotoxic agents was revolutionary for anticancer therapy. These therapies have resulted in better understanding of cancer in general. However, the development of agents that combine efficacy, safety and convenience remains a great challenge. The narrow, if not adverse, therapeutic index of most drugs, the damage not only to cancer cells, but also to normal and healthy tissue and the occurrence of resistance have limited anticancer efficacy. This review presents the development of promising novel cytotoxic solasodine rhamnosyl glycoside drugs that offer not only gains in specificity and efficacy, but also in safety, tolerability, non-resistance and convenience in the treatment of patients with cancer.

关键词： Cancer Skin Cancer Solamargine Solasonine BEC Solasodine rhamnosyl Glycosides CuradermBEC5 Apoptosis Antineoplastic Targeted Therapy

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Topical Solasodine rhamnosyl Glycosides Derived From the Eggplant Treats Large Skin Cancers: Two Case Reports

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International Journal of Clinical Medicine 2011年第4期2卷 473-477页

作者： Bill E. Cham 不详

Solasodine rhamnosyl glycosides (BEC) are a new class of antineoplastics that show superior efficacy than many established anticancer drugs as shown by intravenous, intraperitoneal and intralesion administrations. Previous studies have described the efficacy of BEC on nonmelanoma skin cancers by topical application. Two cases are now reported which show that BEC in a cream formulation Curaderm is very effective for the treatment of large nonmelanoma skin cancers that are considered difficult to treat by existing modalities. Moreover, the cosmetic outcomes are very impressive.

关键词： Nonmelanoma Skin Cancers Solasodine rhamnosyl Glycosides Curaderm Solamargine Solasonine

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Curaderm<sup>BEC5</sup>for Skin Cancers, Is It? An Overview

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Journal of Cancer Therapy 2011年第5期2卷 728-745页

作者： Tania Robyn Chase 不详

Skin cancer incidence is increasing at alarming rates and is considered by some as an epidemic. Its incidence is higher than all other cancers combined. The developments of new treatments have not parallelled the increased incidences of this disease. A variety of treatments are available with differing outcomes. More recently a novel topical treatment, consisting of the antineoplastic compounds solasodine rhamnosyl glycosides, solamargine and solasonine, which are derived from plant material, has been described that claims to have many advantages over the currently used skin cancer therapies. This review investigates such claims.

关键词： Nonmelanoma Skin Cancers Solasodine rhamnosyl Glycosides Curaderm Solamargine Solasonine

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