检索结果-南通市图书馆

Radiation-induced malignant rhabdoid tumour of the hypothalamus in an adult: A case report

World Journal of Clinical Oncology 2019年第11期10卷 375-381页

作者： Pei-Meng Ng Peh-Hueh Low Donald Ngian-San Liew Albert Sii-Hieng Wong Department of Neurosurgery Sarawak General Hospital

BACKGROUND rhabdoid tumours of the central nervous system are highly malignant and extremely rare in adults.To the best of our knowledge,only 87 cases of malignant rhabdoid tumour have been reported to date,inclusive of 4 cases with presumed radiation-induced aetiology.We report a case of malignant rhabdoid tumour in an adult with presumed radiation-induced aetiology to enrich the armamentarium of this disease entity,which may have some implications for early diagnosis and treatment of this rare disease in the future.CASE SUMMARY A 27-year-old male,who was exposed to cranial irradiation at the age of 4 years as part of the treatment for acute lymphoblastic leukaemia,presented with symptoms of raised intracranial pressure for one week.Brain magnetic resonance imaging revealed a heterogeneously enhancing lesion at the hypothalamus.Stereotactic biopsy was performed.Histopathological examination of the lesion showed malignant rhabdoid tumour.The disease progressed rapidly,with manifestation of leptomeningeal spread.He was started on craniospinal irradiation but treatment was suspended after 5.4 Gy,as he developed myelosuppression.His clinical condition deteriorated rapidly,and he succumbed to his illness within 2 mo.CONCLUSION This fifth case of radiation-induced central nervous system rhabdoid tumour reenforces the aggressive nature of this disease with poor prognosis.

关键词： Malignant rhabdoid tumour Atypical teratoid rhabdoid tumour Radiation induced malignancy Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Desmoplastic small round cell tumor with atypical immunohistochemical profile and rhabdoid-like differentiation

引用

World Journal of Clinical Cases 2014年第8期2卷 367-372页

作者： Li Liang Nina Tatevian Meenakshi Bhattacharjee Kuojen Tsao John Hicks Department of Pathology and Laboratory Medicine the University of Texas Health Science Center at HoustonHoustonTX 77030United States Department of Pediatric Surgery the University of Texas Health Science Center at HoustonHoustonTX 77030United States Department of Pathology Texas Children’s HospitalHoustonTX 77030United States

Desmoplastic small round cell tumor(DSRCT) is a rare,aggressive malignant neoplasm of unknown origin, and is comprised of small round cells with a characteristic desmoplastic stroma. DSRCT typically expresses epithelial, mesenchymal and neural markers simultaneously. We describe a case of DSRCT with an atypical immunohistochemical profile and rhabdoid-like tumor cells on electron microscopy. In the present case, the neoplastic cells were positive only for vimentin, desmin(cytoplasmic membranous pattern) and CD56,and negative for smooth muscle actin, synaptophysin,CD117, CD45, myogenin, CAM5.2, pancytokeratin,WT1, EMA, CD99, neurofilament, CD34 and p53. Ki67 showed a low proliferative activity. Electron microscopy showed focal rhabdoid differentiation. However, INI-1(SNF-5/BAF47) demonstrated preservation of nuclear positivity in the neoplastic cells. Cytogenetic studies showed translocation t(11;22)(p13;q12) confirming an EWSR1-WT1 translocation characteristic for DSRCT, and t(1;15)(q11;p11.2) of unknown significance. This case is a diagnostic challenge because of atypical immunohistochemical profile and cytogenetic study is crucial in rendering the correct diagnosis.

关键词： Desmoplastic small round cell tumor Ultrastructure Cytogenetics rhabdoid cells EWSR1-WT1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：