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X-linked Charcot-Marie-Tooth disease after SARS-CoV-2 vaccination mimicked stroke-like episodes: A case report

World Journal of Clinical Cases 2023年第2期11卷 464-471页

作者： Qiang Zhang Yang Wang Run-Tao Bai Bao-Rong Lian Yu Zhang Li-Ming Cao Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518000Guangdong ProvinceChina Shantou University Medical College Shantou UniversityShantou 515063Guangdong ProvinceChina Clinical College of The Shenzhen Second People's Hospital Anhui Medical UniversityShenzhen 518000Guangdong ProvinceChina Hunan Key Laboratory of The Research and Development of Novel Pharmaceutical Preparations Changsha Medical UniversityChangsha 410219Hunan ProvinceChina

BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) vaccinations have been administered worldwide, with occasional reports of associated neurological complications. Specifically, the impact of vaccinations on individuals with Xlinked Charcot-Marie-Tooth disease type 1(CMTX1) is unclear. Patients with CMTX1 can have stroke-like episodes with posterior reversible encephalopathy syndrome on magnetic resonance imaging(MRI), although this is *** SUMMARY A 39-year-old man was admitted with episodic aphasia and dysphagia for 2 d. He received SARS-CoV-2 vaccination 39 d before admission. Physical examination showed pes cavus and reduced tendon reflexes. Brain MRI showed bilateral, symmetrical, restricted diffusion with T2 hyperintensities in the cerebral hemispheres. Nerve conduction studies revealed peripheral nerve damage. He was diagnosed with Charcot-Marie-Tooth disease, and a hemizygous mutation in the GJB1 gene on the X chromosome, known to be pathogenic for CMTX1, was identified. Initially, we suspected transient ischemic attack or demyelinating leukoencephalopathy. We initiated treatment with antithrombotic therapy and immunotherapy. At 1.5 mo after discharge, brain MRI showed complete resolution of lesions, with no *** SARS-CoV-2 vaccination could be a predisposing factor for CMTX1 and trigger a sudden presentation.

关键词： X-linked Charcot-Marie-Tooth disease SARS-CoV-2 vaccination Stroke-like episodes reversible splenial lesion syndrome Demyelinating leukoencephalopathy Case report

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