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reversible protein adsorption on PMOXA/PAA Based Coatings:Role of PAA

Chinese Journal of Polymer Science 2018年第12期36卷 1328-1341页

作者： Fatima Mumtaz Chao-Shi Chen Hai-Kun Zhu Muhammad Atif Yan-Mei Wang Chinese Academy of Sciences Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China

In this study we report design of stimuli-resP0nsive coating based on poly（2-methyl-2-oxazoline-random-glycidyl methacrylate）（PMOXA-r-GMA） comb copolymer and poly（acrylic acid）-block-poly（glycidyl methacrylate）（PAA-b-PGMA） block copolymers and scrutinize its ability to control protein adsorption. Firstly, PMOXA/PAA based coatings were prepared by simply spin coating the mixture of PMOXA-r-GMA and PAA-b-PGMA copolymer solutions onto silicon substrates followed by annealing at 110℃. Then coatings were rigorously characterized by X-ray photoelectron spectroscopy （XPS）, the static water contact angle （WCA） test, ellipsometry and atomic force microscopy （AFM）. After that, the relationship of switchable behavior of PMOXA/PAA based coatings with PAA content and chain length was investigated through the change of thickness and WCA upon pH and ionic strength （I） trigger, which indicated that the change in thickness and WCA was triggered when PAA contents were increased as well as by increasing chain length of PAA in PMOXA/PAA based coatings. Finally, real-time adsorption/desorption of lysozyme （Lyso） on PMOXA/PAA based coatings was monitored using quartz crystal microbalance with dissipation monitoring （QCM-D）. The results showed that the Lyso adsorption amount was increased upon increasing chain length and contents of PAA in PMOXA/PAA based coatings. The adsorbed Lyso was then efficiently desorbed by changing pH and I of medium with the maximum desorption （〉 90% desorption percentage） observed for the suitable ratio of PMOXA and PAA while chain length of PAA was kept longer than that of PMOXA. Furthermore, the prepared coatings were found to repeatedly adsorb and desorb Lyso for four successive cycles of adsorption/desorption, which confirmed the stability of prepared coatings.

关键词： Binary polymer brushes Stimuli-responsive coating reversible protein adsorption Quartz crystal microbalance

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