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Phthalate Exposure and Human Semen Quality in Shanghai:A Cross-sectional Study

Biomedical and Environmental Sciences 2006年第3期19卷 205-209页

作者： YUN-HUI ZHANG LI-XING ZHENG BING-HENG CHEN Department of Environmental Health School of Public Health Fudan University Shanghai 200032 China

Objective To monitor the level of phthalates in human semen samples and to analyze the relationship between phthalate levels and semen parameters. Methods Concentrations of three kinds of commonly used phthalates （di-ethyl phthalate, DEP; di-n-butyl phthalate, DBP; di-2-ethylhexyl phthalate, DEHP） were measured using reversed-phase hplc. Semen parameters were measured by computer aided sperm analysis （CASA）. Results The three phthalates were detected in most of the biological samples, with median levels of 0.30 mg/L （0.08-1.32 mg/L） in semen specimens. There was a significant positive association between liquefied time of semen and phthalate concentrations of semen. The correlation coefficient was 0.456 for DEP, 0.475 for DBP, and 0.457 for DEHP, respectively. There was no significant difference between phthalate concentrations of semen and sperm density or livability, though the correlation coefficients were negative. Conclusion These results suggest that people who reside in Shanghai are exposed to phthalates, especially to DBP and DEHP. Although the level of phthalates is relatively mild, an association of phthalate levels and reduced quality of human semen has been shown in the present study.

关键词： Environmental endocrine disruptor Phthalates reversed-phase hplc Biological samples

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Lipophilicity determination of N-( benzothiazol-2-yl )-α-amino alkyl phosphonic diesters by RP-hplc and RP-HPTLC

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Chinese Journal of Chemistry 2000年第6期18卷 872-876页

作者：张玲李在国黄润秋王琴孙 State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China

Using methanol-water mixtures as the mobile phase, the chromatographic retention parameters k' and Rf were determined by reversed-phase high-performance liquid chromatography (RP-hplc) and reversed-phase high-performance thin-layer chromatography (RP-HPTLC) for N-(benzothiazol-2-yl)-α-amino alkyl phosphoric diesters and the correlation with lipophilicity parameter (Clog P) was established. Log Kw values obtained from RP-hplc and Rm values obtained from RP-HPTLC can be used to evaluate the lipophilicity of this kind of compounds. Chromatographic method is a good alternative for lipophilicity measurement.

关键词： reversed-phase hplc reversed-phase HPTLC N-(benzothiazol-2-yl])-α-amino alkyl phosphonic diesters lipophilicity determination

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