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中国植物病理学会2021年学术年会

作者： WANG Sen WANG Yu LIU Yinghang LIU Lin LI Jinyu YANG Kunlong LIU Mengxin ZENG Wanlin QIN Ling NIE Xinyi JIANG Longguang WANG Shihua State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Key Laboratory of Pathogenic Fungi and Mycotoxins of Fujian Provinceand School of Life SciencesFujian Agriculture and Forestry University College of Chemistry Fuzhou University

The retromer complex is responsible for the reverse transport of specific biomolecules from endosomes to the Golgi ***,the role of retromer complex in Aspergillus flavus is still ***,we report that the cargo-recognition complex which is constituted of three vacuolar protein sorting-associated proteins（AflVps26-AflVps29-AflVps35）,is essential for development of onidia and sclerotia,aflatoxin production and pathogenicity in ***,the AflVps26-AflVps29-AflVps35 complex is negatively correlated with aflatoxin *** structural simulation,site-specific mutagenesis,and Co-immunoprecipitation experiments,it showed that interactions among AflVps26,AflVps29 and AflVps35 played a crucial role during retromer complex executing its core ***,AflVps35 directly bound to AflRab7,and mutations in the binding site indicated that they work together to regulate the production of *** found that intrinsic connection between AflRab7 and retromer involves in vesicle-vacuole fusion,then affects accumulation of aflatoxin-synthesis associated enzymes,suggesting that retromer complex did not merely exhibit reverse traffic function in ***,these results provided mechanistic insights to understand the regulatory role of retromer cargo-recognition complex in aflatoxins metabolism.

关键词： Aspergillus flavus retromer complex aflatoxin AflRab7

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Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway

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Genes & Diseases 2021年第2期8卷 232-240页

作者： Yi Liu Haijun Deng Li Liang Guiji Zhang Jie Xia Keyue Ding Ni Tang Kai Wang Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education) Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqing400016PR China Department of Bioinformatics School of Basic MedicineChongqing Medical UniversityChongqing400016PR China

Vesicle Protein Sorting 35(VPS35)is a novel oncogene that promotes tumor growth through the PI3K/AKT signaling in hepatocellular carcinoma(HCC).However,the role of VPS35 in HCC metastasis and the underlying mechanisms remain largely *** this study,we observed that overexpression of VPS35 enhanced hepatoma cell invasion and metastasis by inducing epithelialemesenchymal transition(EMT)-related gene ***,knockout of VPS35 significantly inhibited hepatoma cell migration and ***,depletion of VPS35 decreased the lung metastasis of HCC in nude *** transcriptome analysis,we determined that VPS35 promoted HCC metastasis by activating the Wnt/non-canonical planar cell polarity(PCP)***,VPS35 activated the PCP pathway by regulating membrane sorting and trafficking of Frizzled-2(FZD2)and ROR1 in hepatoma ***,our results indicate that VPS35 promotes HCC metastasis via enhancing the Wnt/PCP signaling,thus providing a potential prognostic marker and therapeutic target for HCC.

关键词： Epithelial emesenchymal transition Hepatocellular carcinoma(HCC) Metastasis retromer complex VPS35 Wnt/PCP signaling pathway

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Function analysis of vacuolar protein sorting vps26、vps29 and vps35 in Aspergillus flavus

Function analysis of vacuolar protein sorting vps26、vps29 a...

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中国植物病理学会2019年学术年会

作者： Wang Sen Wang Yu Liu Yinghang Wang Shihua Key Laboratory of Pathogenic Fungi and Mycotoxins of Fujian Province Key Laboratory of Biopesticide and Chemical Biology of Education Ministryand School of Life SciencesFujian Agriculture and Forestry University State Key Laboratory of Microbial Technology Shandong University

In eucaryon,the retromer complex are responsible for retrograding transport of receptors from endosomes to the trans-Golgi network,which play vital roles in regulation of growth and development ***,we study the functions of the subunits of retromer complex,Cargo-Selective subunit in fungal development,pathopoiesity and aflatoxin biosynthesis in *** identified CargoSelective subunit that is a retromer including Vps26,Vps29 and Vps35 via bioinformatics *** disruption mutants exhibited dramatic reduction in hyphal growth,conidiation,sclerotia production,and also displayed remarkable reduction in aflatoxin *** stress experiments revealed that the vps genes deletion mutants were more sensitive to the stress factors when compared to the *** also found that vps gene deleted strains were reduced in the ability of infecting crop seeds,while the aflatoxin yield was increased when infecting *** study on proteins’ subcellular location showed that Vps26,Vps29 and Vps35 were all compartmentalized punctuated structures near *** interaction pattern among Vps26,Vps29 and Vps35 were also performed by Yeast two-hybrid *** conclusion,Vps26,Vps29 and Vps35 included in theretromer complex all take part in the process of growth and development,pathopoiesis and aflatoxin biosyntheses in *** study is useful for understanding the function of the retromer complex,and would provide valuable imformation for the controling of ***.

关键词： Aspergillus flavus retromer complex Vacuolar protein sorting Aflatoxin

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