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Rotational Intravascular Multidirectional Ultrasound Catheter for Sonothrombolysis of retracted clots:An in Vitro and in Vivo Study

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Engineering 2024年第11期42卷 235-243页

作者： Huaiyu Wu Jinwook Kim Bohua Zhang Gabe Owens Greyson Stocker Mengyue Chen Benjamin C.Kreager Ashley Cornett Kathlyne Bautista Tarana Kaovasia Paul A.Dayton Zhen Xu Xiaoning Jiang Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleighNC 27695USA Joint Department of Biomedical Engineering The University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Biomedical Engineering University of MichiganAnn ArborMI 48109USA

Thromboembolism in blood vessels poses a serious risk of stroke,heart attack,and even sudden death if not properly *** combined with ultrasound contrast agents has emerged as a promising approach for the effective treatment of *** reports have highlighted the potential of intravascular sonothrombolysis as a safe and effective treatment modality for deep vein thrombosis(DVT).However,its efficiency has not been validated through in vivo testing of retracted *** study aimed to develop a miniaturized multidirectional transducer featuring two 4-layer lead zir-conate titanate(PZT-5A)stacks with an aperture size of 1.4 mm1.4 mm,enabling both forward-and side-looking *** into a custom two-lumen 10-French(Fr)catheter,the capability of this device for intravascular sonothrombolysis was validated both in vitro and in *** low-dose tissue plasminogen activators and nanodroplets,the rotational multidirectional transducer reduced the retracted clot mass(800 mg)by an average of 52%within 30 min during in vitro *** lysis rate was significantly higher by 37%than that in a forward-viewing transducer without *** improvement was particularly noteworthy in the treatment of retracted ***,a long-retracted clot(>10 cm)was successfully treated within 40 min in vivo by creating a flow channel with a diameter>4 mm in a porcine DVT *** conclusion,these findings strongly suggest the potential of this technique for clinical applications in sonothrombolysis,offering a feasible solution for effectively treating thromboembolism,particularly in challenging cases involving retracted clots.

关键词： Intravascular ultrasound catheter Sonothrombolysis in vivo retracted clots thrombolysis

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