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New frontiers in retinal transplantation

World Journal of transplantation 2024年第4期14卷 67-77页

作者： Francesco Saverio Sorrentino Patrick Di Terlizzi Francesco De Rosa Carlo Salati Leopoldo Spadea Caterina Gagliano Mutali Musa Marco Zeppieri Department of Surgical Sciences Unit of OphthalmologyOspedale MaggioreBologna 40100Italy Department of Oncology IRCCS Istituto Romagnolo per lo Studio dei Tumori“Dino Amadori”Meldola 47014Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100Italy Eye Clinic Catania University San Marco HospitalCatania 95121Italy Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Centre for Sight AfricaNkporOnitsha 434112Nigeria

New frontiers about retinal cell transplantation for retinal degenerative diseases start from the idea that acting on stem cells can help regenerate retinal layers and establish new synapses among retinal *** or alterations of synaptic input and neurotrophic factors result in trans-neuronal degeneration of the inner retinal ***,the disruption of photoreceptors takes ***,even in advanced forms of retinal degeneration,a good percentage of the ganglion cells and the inner nuclear layer neurons remain *** phenomenon provides evidence for obtaining retinal circuitry through the transplantation of photoreceptors into the subretinal *** eye is regarded as an optimal organ for cell transplantation because of its immunological privilege and the relatively small number of cells collaborating to carry out visual *** eyeball's immunological privilege,characterized by the suppression of delayed-type hypersensitivity responses in ocular tissues,is responsible for the low rate of graft rejection in transplant *** main discoveries highlight the capacity of embryonic stem cells(ESCs)and induced pluripotent stem cells to regenerate damaged retinal *** progress has shown significant enhancements in transplant procedures and *** research also explores the ethical ramifications linked to the utilization of stem cells,emphasizing the ongoing issue surrounding *** analysis centers on recent breakthroughs,including the fabrication of three-dimensional retinal organoids and the innovation of scaffolding for cell ***,researchers are currently assessing the possibility of CRISPR and other advanced gene editing technologies to enhance the outcomes of retinal *** widespread use of universally recognized safe surgical and imaging methods enables retinal transplantation and monitoring of transplanted cell growth toward the correct ***,most therapy approaches

关键词： retinal transplantation retinal stem cell Human embryonic stem cells Pluripotent stem cells retinal tissue transplant

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