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retinal prosthesis:A Potential Benefit for the Blind

Chinese Journal of Biomedical Engineering(English Edition) 2009年第2期18卷 55-66页

作者： YANG Xiao-jie Melbourne School of Engineering the University of Melbourne Melbourne Victoria 3010 Australia

retinal degenerative diseases may induce the degeneration of outer retina and in turn,***,due to the maintenance of inner retina,the coding and processing of visual neurons responses are still able to be executed ***,an effective retinal prosthesis device may be developed by mimicking the function of outer retina:transferring the visual light into artificial stimulus and delivering the stimulus to the retina aiming to evoke the neural *** two main developing directions for current retinal prosthesis,epiretinal(ER)and subretinal(SR)prosthesis are both undergoing experimental stage and possessing advantages and *** investigations in power supply,biocompatibility,*** still ***,suprachoroidal transretinal stimulation(STS)and neurotransmitter-induced stimulation as some other alternatives in retinal prosthesis are also considered as promising research directions,although they are not mature enough to be applied commercially,either.

关键词： retinal prosthesis ER prosthesis SR prosthesis artificial vision

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Electrical stimulation scheme optimization for retinal prosthesis:considerations from biological perspective

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Annals of Eye Science 2020年第2期5卷 21-25页

作者： Zhen Xu Yijie Lu Shan Qin Tianzhun Wu Bo Qin Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Shenzhen Shekou People’s Hospital the Second Xiangya Hospital of Central South University Shenzhen HospitalShenzhen 518067China

Effective and safe electrical stimulation of the retinal ganglion cells is at the heart of retinal prosthesis ***,the effectiveness and safety demand of the electrical stimulation is often at odds against each ***,the nerve fiber layer above retinal ganglion cells limits the spatial resolution of ***,current retinal prosthesis still cannot selectively activate the ON or OFF visual pathways,thus cannot relay the correct luminance information to the *** decades of development,the stimulation protocol for retinal implants began to tackle these *** believe that a novel design of electrical stimulation scheme,combined with gene therapy technique,can improve the selectivity and spatial resolution of retinal implants and further lower the damage caused by electric stimulation.

关键词： retinal prosthesis electrical stimulation nerve fiber layer,retinal ganglion cell gene therapy ON and OFF visual pathway

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An Optoelectronic Pulse Frequency Modulation Circuit for retinal prosthesis

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Journal of Semiconductors 2006年第4期27卷 700-704页

作者：刘金彬陈弘达高鹏裴为华隋晓红中国科学院半导体研究所集成光电子学国家重点实验室北京100083

A pulse frequency modulation（PFM） circuit for retinal prosthesis,which generates electrical pulses with frequency proportional to the intensity of incident light, is presented. The fundamental characteristic of the circuit is described and analyzed. The circuit is realized in 0.6μm CMOS process,and the simulation results testify to the possibility of sub-retinal implantation.

关键词： retinal prosthesis sub-retinal implant pulse frequency modulation

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AB032. Exploring the effects of a retinal prosthesis on visual hallucinations related to Charles Bonnet syndrome

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Annals of Eye Science 2019年第1期 207-207页

作者： Vincent Moore Marie Courchesne Mathieu Carignan Sylvie Cantin Frédérique Poncet Institut Nazareth et Louis-Braille du CISSS de la Montérégie-Centre LongueuilQCCanada Centre de Recherche Interdisciplinaire en Readaptation du Montreal Metropolitain MontréalQCCanada Concordia University MontréalQCCanada

Background:A first occurrence in the province of Quebec(Canada)of the use of a retinal prosthesis system(RPS)by a patient with a Charles Bonnet syndrome(CBS)provides a rare opportunity to explore the effects of this system on visual hallucinations(VH)related to *** that the RPS artificially induces a visual perception and that VH related to CBS occur in cases of significant vision loss,this study aimed to explore whether the recovery of a visual perception could affect the nature and frequency of VH related to ***:This is a case study with time series and repeated experimentation:a pre-intervention measure to establish the baseline level,two implant activation periods(A1 and A2)and a post-intervention measure(3 for each activation).The study is based on a 65-year-old man with retinitis *** has been functionally blind for about ten years and was completely blind at the time of the *** began to perceive VH corresponding to the CBS after a significant decrease of his visual *** the time of the study,these VH were frequent and often *** receiving the Argus II RPS,he participated,along with INLB staff,in an intensive rehabilitation program aiming at optimizing the use of the *** explore the effects of the RPS,we collected visual,cognitive,and mood-related data and documented the VH using the Charles Bonnet Syndrome Screening Questionnaire(Cantin et al.,2018).Results:The visual acuity and visual field measurements show a significant improvement with the use of the RPS(visual acuity of 2.3 logMAR and visual fields of 12 degrees).Measurements of cognitive functions have shown high,stable,and close to the maximum *** data revealed low and relatively stable depression and anxiety scores over the course of the *** documented VH showed the characteristic features of *** nature and frequency of VH have varied widely over the study ***:The RPS improved the visual perceptions of the

关键词： retinal prosthesis Charles Bonnet syndrome(CBS) visual impairment

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Safety,effectiveness,and cost-effectiveness of ArgusⅡin patients with retinitis pigmentosa:a systematic review

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International Journal of Ophthalmology(English edition) 2021年第2期14卷 310-316页

作者： Zakieh Ostad-Ahmadi Amin Daemi Mohammad-Reza Modabberi Ali Mostafaie Department of Health Management Policy and EconomicsSchool of Management and Medical InformaticsKerman University of Medical SciencesKerman ***Iran Health Management and Economics Research Center Iran University of Medical SciencesTehran ***Iran Student Research Committee School of Public HealthShahid Beheshti University of Medical SciencesTehran 198353Iran Iranian Center for Evidence Based Medicine Tabriz University of Medical SciencesTabriz ***Iran

AIM:To assess the effectiveness,safety,and costeffectiveness of the Argus II in treatment of the retinitis pigmentosa(RP)***:The Pro Quest,Web of Science,EMBASE,MEDLINE(via Pub Med)were searched using combinations of the keywords of Argus,safety,effectiveness,bionic eye,retinal prosthesis,and RP through March *** retrieved records were screened and then assessed for ***:Totally 926 records were retrieved from the searched databases and finally 12 studies *** RP patients showed improvements in visual function after receiving the prosthesis,compared to the time before the prosthesis or the time it was *** was measured by square localization,direction of motion,and grating visual acuity *** major adverse effect was reported for the Argus II prosthesis itself and/or the surgery to implement it,but the most frequently reported items were hypotony,and conjunctival *** incremental cost-effectiveness ratio(ICER)was calculated to be€14603 per qualityadjusted life year(QALY)in UK and$207616 per QALY in ***:The available evidence shows that the Argus II prosthesis in RP patients is effective in improvement of their visual *** minor adverse effects are reported for the *** cost-effectiveness studies show that the technology is cost-effective only at high levels of willingness-to-pay.

关键词： retinitis pigmentosa ArgusⅡ retinal prosthesis effectiveness adverse cost-effectiveness

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