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Characterization of retinal microvasculature in acute non-arteritic anterior ischemic optic neuropathy using the retinal functional imager: a prospective case series

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Eye and Vision 2019年第1期6卷 17-22页

作者： Amanda D.Henderson Hong Jiang Jianhua Wang Wilmer Eye Institute Johns Hopkins University School of Medicine600 N.Wolfe StreetWilmer 233BaltimoreMD 21231USA Bascom Palmer Eye Institute University of MiamiMiller School of Medicine900 NW 17th StreetMiamiFL 33136USA

Background:Non-arteritic anterior ischemic optic neuropathy(NAION)is the most common cause of acute optic neuropathy in patients over 50 years of age,and many affected individuals are left with permanent visual *** the frequency of NAION and its often devastating effects on vision,no effective treatment has been *** understanding of the acute vascular effects in NAION,using advanced ophthalmic imaging techniques like the retinal function imager,may shed light on potential treatment ***:Five patients with acute NAION underwent retinal functional imaging within 2 weeks of the onset of their visual symptoms,and at 1 month and 3 months after *** arteriolar and venular blood flow velocities were calculated for each eye at each time *** Wilcoxon rank sum test was used to compare blood flow velocity results with a normative ***:The average arteriolar blood flow velocity in the normative group was 3.8 mm/s,and the average venular blood flow velocity was 3.0 mm/s,versus 4.1 mm/s and 2.7 mm/s,respectively,in the NAION-affected group at *** arteriolar blood flow increased slightly to 4.2 mm/s one month after the acute NAION event,then decreased to 3.8 mm/s three months after the *** venular blood flow velocity was 2.8 mm/s 1 month after the NAION event and 2.7 mm/s 3 months after the *** in blood flow velocity between the NAION-affected and control groups were not statistically significant at any time point;however,there was a trend toward increasing blood flow velocity initially after an NAION,with a decrease over ***:This study demonstrates the feasibility of retinal function imaging to quantify macular blood flow velocity in patients with acute *** were no statistically significant differences in blood flow velocity detected between NAION-affected eyes and healthy controls at any of the time points examined;however,there was a trend toward an i

关键词： retinal functional imager Non-arteritic anterior ischemic optic neuropathy Blood flow velocity

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