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Paired Immunoglobulin-like Receptor B Inhibition in Müller cells Promotes Neurite Regeneration After retinal ganglion cell injury in vitro

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Neuroscience Bulletin 2020年第9期36卷 972-984页

作者： Rongdi Yuan Mei Yang Wei Fan Jian Lan Yuan-Guo Zhou Department of Ophthalmology Xinqiao HospitalArmy Medical UniversityChongqing 400037China The Molecular Biology Centre State Key Laboratory of TraumaBurn and Combined InjuryResearch Institute of Surgery and Daping HospitalArmy Medical UniversityChongqing 400042China

In the central nervous system(CNS),three types of myelin-associated inhibitors(MAIs) have major inhibitory effects on nerve *** include Nogo-A,myelin-associated glycoprotein,and oligodendrocyte-myelin *** possess two co-receptors,Nogo receptor(NgR) and paired immunoglobulin-like receptor B(PirB).Previous studies have confirmed that the inhibition of NgR only results in a modest increase in regeneration in the CNS;however,the inhibitory effects of PirB with regard to nerve regeneration after binding to MAIs remain *** this study,we demonstrated that PirB is expressed in primary cultures of retinal ganglion cells(RGCs),and the inhibitory effects of the three MAIs on the growth of RGC neurites are not significantly decreased after direct PirB knockdown using adenovirus PirB ***,we found that retinal Müller cells expressed PirB and that its knockdown enhanced the regeneration of co-cultured RGC *** knockdown also activated the JAK/Stat3 signaling pathway in Müller cells and upregulated ciliary neurotrophic factor *** findings indicate that PirB plays a novel role in retinal Müller cells and that its action in these cells may indirectly affect the growth of RGC *** results also reveal that PirB in Müller cells affects RGC neurite *** findings provide a novel basis for the use of PirB as a target molecule to promote nerve regeneration.

关键词： Neurite regeneration Müller cell retina ganglion cell injury Ciliary neurotrophic factor

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