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Spirometric Changes during Pregnancy in Cystic Fibrosis Patients

Open Journal of respiratory Diseases 2021年第1期11卷 19-25页

作者： Clay Wu Gloria Wu Lynn Fukushima Adupa P. Rao Ahmet Baydur Division of Pulmonary Critical Care and Sleep Medicine University of Southern California Los Angeles California USA Department of Internal Medicine University of Southern California Los Angeles California USA

Rationale: Survival and longevity in patients with cystic fibrosis (CF) have improved with new treatments, so that pregnancy can be safely undertaken despite physiologic limitations. Dyspnea still develops in the latter stages of pregnancy. To explain this symptom, we evaluated the effect of pregnancy on lung function before and after delivery. Methods: Records of 23 pregnant patients with CF were retrospectively reviewed for data analysis. Spirometry was recorded prior to pregnancy, at first and third trimesters, and every three months following delivery up to one year. Comparisons between time points were adjusted for age and pre-gestational BMI by analysis of variance (ANOVA). Results: Complete clinical and spirometric data were available for eleven of these patients (13 pregnancies total), obtained between 2009 and 2017. FEV1 and FVC declined significantly from baseline to third trimester (by 8.1%, p Conclusions: The changes in FEV1 and FVC occur as a result of increases in intravascular blood volume and lung water during the third trimester. At the same time, FEV1/FVC increases as there is reversal of bronchiolar constriction with elimination of extracellular fluid and lung water. Furthermore, restoration of end-expiratory lung volume post-partum counte

关键词： Pulmonary Cystic Fibrosis Pregnant Women Spirometry respiratory physiological phenomena

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