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Lensless polarimetric coded ptychography for high-resolution,high-throughput gigapixel birefringence imaging on a chip

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Photonics Research 2023年第12期11卷 2242-2255页

作者： LIMING YANG RUIHAI WANG QIANHAO ZHAO PENGMING SONG SHAOWEI JIANG TIANBO WANG XIAOPENG SHAO CHENGFEI GUO RISHIKESH PANDEY GUOAN ZHENG School of Optoelectronic Engineering Xidian UniversityXi’an 710071China Department of Biomedical Engineering University of ConnecticutStorrsConnecticut 06269USA

Polarimetric imaging provides valuable insights into the polarization state of light interacting with a sample.It can infer crucial birefringence properties of specimens without using labels,thereby facilitating the diagnosis of diseases such as cancer and osteoarthritis.In this study,we present a novel polarimetric coded ptychography(pol-CP)approach that enables high-resolution,high-throughput gigapixel birefringence imaging on a chip.Our platform deviates from traditional lens-based systems by employing an integrated polarimetric coded sensor for lensless coherent diffraction imaging.Utilizing Jones calculus,we quantitatively determine the birefringence retardance and orientation information of biospecimens from the recovered images.Our portable pol-CP prototype can resolve the 435 nm linewidth on the resolution target,and the imaging field of view for a single acquisition is limited only by the detector size of 41 mm2.The prototype allows for the acquisition of gigapixel birefringence images with a 180 mm^(2) field of view in~3.5 min,a performance that rivals high-end whole slide scanner but at a small fraction of the cost.To demonstrate its biomedical applications,we perform high-throughput imaging of malaria-infected blood smears,locating parasites using birefringence contrast.We also generate birefringence maps of label-free thyroid smears to identify thyroid follicles.Notably,the recovered birefringence maps emphasize the same regions as autofluorescence images,underscoring the potential for rapid on-site evaluation of label-free biopsies.Our approach provides a turnkey and portable solution for lensless polarimetric analysis on a chip,with promising applications in disease diagnosis,crystal screening,and label-free chemical imaging,particularly in resource-constrained environments.

关键词： polarization birefringence resolution

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Photonics-enabled distributed MIMO radar for high-resolution 3D imaging

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Photonics Research 2022年第7期10卷 1679-1688页

作者： JINGWEN DONG QIANG SUN ZEKUN JIAO LIQI ZHANG ZIQIANG YIN JIAJIE HUANG JINGHAN YU SHU WANG SHANGYUAN LI XIAOPING ZHENG WANGZHE LI National Key Laboratory of Microwave Imaging Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China School of Electronics Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China Beijing National Research Center for Information Science and Technology Department of Electronic EngineeringTsinghua UniversityBeijing 100084China

Three-dimensional(3D)imaging radar is an advanced sensor applied in space surveillance and target recognition for supplying 3D geometric features and supporting visualization.However,high 3D resolution requires both broadband operation and a large 2D aperture,which are difficult and complex for conventional radars.This paper presents a photonics-enabled distributed multiple-input and multiple-output(MIMO)radar with a centralized architecture.By use of photonic multi-dimensional multiplexing,multi-channel signal generation and reception are implemented on a shared reference signal in a central office,enabling a highly coherent network with a simple structure.Additionally,a sparse array and a synthetic aperture are combined to efficiently reduce the required transceivers,further weakening the dilemma between system complexity and angular resolution.A 4×4 MIMO radar is established and evaluated in field tests.A high-resolution 3D image of a non-cooperative aircraft is obtained,in which rich details are displayed.From a comparison with electronics-based radar,significant resolution improvement is observed.The results verify the superior imaging capability and practicability of the proposed radar and its great potential to outperform conventional technologies in target classification and recognition applications.

关键词： MIMO resolution details

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Super-resolution computed tomography imaging spectrometry

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Photonics Research 2023年第2期11卷 212-224页

作者： LEI YUAN QIANG SONG HECONG LIU KEVIN HEGGARTY WEIWEI CAI Key Laboratory for Power Machinery and Engineering of the Ministry of Education School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Lochn Optics Shenzhen 518200China Optics Department IMT-AtlantiqueTechnopole Brest-IroiseCS 8381829285 BrestFrance

Computed tomography imaging spectrometry(CTIS) is a snapshot spectral imaging technique that relies on a limited number of projections of the target data cube(2D spatial and 1D spectral), which can be reconstructed via a delicate tomographic reconstruction algorithm. However, the restricted angle difference between the projections and the space division multiplexing of the projections make the reconstruction suffer from severe artifacts as well as a low spatial resolution. In this paper, we demonstrate super-resolution computed tomography imaging spectrometry(SRCTIS) by assimilating the information obtained by a conventional CTIS system and a regular RGB camera, which has a higher pixel resolution. To improve the reconstruction accuracy of CTIS, the unique information provided by the zero-order diffraction of the target scene is used as a guidance image for filtering to better preserve the edges and reduce artifacts. The recovered multispectral image is then mapped onto the RGB image according to camera calibration. Finally, based on the spectral and the spatial continuities of the target scene, the multispectral information obtained from CTIS is propagated to each pixel of the RGB image to enhance its spectral resolution, resulting in SRCTIS. Both stimulative studies and proof-of-concept experiments were then conducted, and the results quantified by key metrics, such as structural similarity index measurement and spectral angle mapping have suggested that the developed method cannot only suppress the reconstruction artifacts, but also simultaneously achieve high spatial and spectral resolutions.

关键词： resolution image filtering

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Super-resolution localization photoacoustic microscopy using intrinsic red blood cells as contrast absorbers

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Light(Science & Applications) 2019年第1期8卷 212-222页

作者： Jongbeom Kim Jin Young Kim Seungwan Jeon Jin Woo BAIK Seong Hee Cho Chulhong Kim Departments of Creative IT Engineering Electrical EngineeringMechanical Engineeringand Interdisciplinary Bioscience and BioengineeringPohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohangGyeongbuk 37673Republic of Korea

Photoacoustic microscopy(PAM)has become a premier microscopy tool that can provide the anatomical,functional,and molecular information of animals and humans in vivo.However,conventional PAM systems suffer from limited temporal and/or spatial resolution.Here,we present a fast PAM system and an agent-free localization method based on a stable and commercial galvanometer scanner with a custom-made scanning mirror(L-PAM-GS).This novel hardware implementation enhances the temporal resolution significantly while maintaining a high signal-to-noise ratio(SNR).These improvements allow us to photoacoustically and noninvasively observe the microvasculatures of small animals and humans in vivo.Furthermore,the functional hemodynamics,namely,the blood flow rate in the microvasculature,is successfully monitored and quantified in vivo.More importantly,thanks to the high SNR and fast B-mode rate(500 Hz),by localizing photoacoustic signals from captured red blood cells without any contrast agent,unresolved microvessels are clearly distinguished,and the spatial resolution is improved by a factor of 2.5 in vivo.LPAM-GS has great potential in various fields,such as neurology,oncology,and pathology.

关键词： resolution absorber scanner

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WISH:wavefront imaging sensor with high resolution

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Light(Science & Applications) 2019年第1期8卷 818-827页

作者： Yicheng Wu Manoj Kumar Sharma Ashok Veeraraghavan Department of Electrical and Computer Engineering Rice UniversityHoustonTXUSA Applied Physics Program Rice UniversityHoustonTXUSA

Wavefront sensing is the simultaneous measurement of the amplitude and phase of an incoming optical field.Traditional wavefront sensors such as Shack-Hartmann wavefront sensor(SHWFS)suffer from a fundamental tradeoff between spatial resolution and phase estimation and consequently can only achieve a resolution of a few thousand pixels.To break this tradeoff,we present a novel computational-imaging-based technique,namely,the Wavefront Imaging Sensor with High resolution(WISH).We replace the microlens array in SHWFS with a spatial light modulator(SLM)and use a computational phase-retrieval algorithm to recover the incident wavefront.This wavefront sensor can measure highly varying optical fields at more than 10-megapixel resolution with the fine phase estimation.To the best of our knowledge,this resolution is an order of magnitude higher than the current noninterferometric wavefront sensors.To demonstrate the capability of WISH,we present three applications,which cover a wide range of spatial scales.First,we produce the diffraction-limited reconstruction for long-distance imaging by combining WISH with a large-aperture,low-quality Fresnel lens.Second,we show the recovery of high-resolution images of objects that are obscured by scattering.Third,we show that WISH can be used as a microscope without an objective lens.Our study suggests that the designing principle of WISH,which combines optical modulators and computational algorithms to sense high-resolution optical fields,enables improved capabilities in many existing applications while revealing entirely new,hitherto unexplored application areas.

关键词： estimation. field. resolution

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Nature protection and human development in the Selincuo region:conflict resolution

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Science Bulletin 2019年第7期64卷 425-427页

作者： Jie Fan Hu Yu Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Key Laboratory of Regional Sustainable Development Modeling Chinese Academy of Sciences

Tibet serves as an important ecological security barrier for China. It has the largest national nature reserves in China, spanning372,000 km2and accounting for 30.94%of the land. Although the national nature reserve has provided ecological benefits, it has also resulted in serious conflicts between nature conservation and human development. Especially in the modernization period since the 21st century, Tibet has played an unprecedented important role in balancing protection and development. In this study, Selincuo, a key region explored during the Second Tibetan Plateau Scientific Expedition, was selected as a case study for discussion.

关键词： In Nature protection and human development in the Selincuo region:conflict resolution

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Breaking the resolution-bandwidth limit of chip-scale spectrometry by harnessing a dispersion-engineered photonic molecule

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Light(Science & Applications) 2023年第3期12卷 475-488页

作者： Hongnan Xu Yue Qin Gaolei Hu Hon Ki Tsang Department of Electronic Engineering The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina

The chip-scale integration of optical spectrometers may offer new opportunities for in situ bio-chemical analysis,remote sensing,and intelligent health care.The miniaturization of integrated spectrometers faces the challenge of an inherent trade-off between spectral resolutions and working bandwidths.Typically,a high resolution requires long optical paths,which in turn reduces the free-spectral range(FSR).In this paper,we propose and demonstrate a ground-breaking spectrometer design beyond the resolution-bandwidth limit.We tailor the dispersion of mode splitting in a photonic molecule to identify the spectral information at different FSRs.When tuning over a single FSR,each wavelength channel is encoded with a unique scanning trace,which enables the decorrelation over the whole bandwidth spanning multiple FSRs.Fourier analysis reveals that each left singular vector of the transmission matrix is mapped to a unique frequency component of the recorded output signal with a high sideband suppression ratio.Thus,unknown input spectra can be retrieved by solving a linear inverse problem with iterative optimizations.Experimental results demonstrate that this approach can resolve any arbitrary spectra with discrete,continuous,or hybrid features.An ultrahigh resolution of100 nm far exceeding the narrow FSR.An ultralarge wavelength-channel capacity of 2501 is supported by a single spatial channel within an ultrasmall footprint(≈60×60μm^(2)),which represents,to the best of our knowledge,the highest channel-to-footprint ratio(≈0.69μm^(−2))and spectral-to-spatial ratio(>2501)ever demonstrated to date.

关键词： resolution dispersion limit

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Soliton microcomb-assisted microring photonic thermometer with ultra-high resolution and broad range

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Photonics Research 2023年第10期11卷 I0001-I0010页

作者： CHENG ZHANG JIN WANG GUOGUO KANG JIANXIN GAO ZHIER QU SHUAI WAN CHUNHUA DONG YIJIE PAN JIFENG QU Center for Advanced Measurement Science National Institute of MetrologyBeijing 100029China School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

Whispering gallery mode resonators(WGMRs)have proven their advantages in terms of sensitivity and precision in various sensing applications.However,when high precision is pursued,the WGMR demands a high-quality factor usually at the cost of its free spectral range(FSR)and corresponding measurement range.In this article,we propose a high-resolution and wide-range temperature sensor based on chip-scale WGMRs,which utilizes a Si_(3)N_(4)ring resonator as the sensing element and a Mg F_(2)-based microcomb as a broadband frequency reference.By measuring the beatnote signal of the WGM and microcomb,the ultra-high resolution of 58 micro-Kelvin(μK)was obtained.To ensure high resolution and broad range simultaneously,we propose an ambiguity-resolving method based on the gradient of feedback voltage and combine it with a frequency-locking technique.In a proof-of-concept experiment,a wide measurement range of 45 K was demonstrated.Our soliton comb-assisted temperature measurement method offers high-resolution and wide-range capabilities,with promising advancements in various sensing applications.

关键词： resonator resolution high

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3D cellular-resolution imaging in arteries using few-mode interferometry

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Light(Science & Applications) 2019年第1期8卷 183-191页

作者： Biwei Yin Zhonglie Piao Kensuke Nishimiya Chulho Hyun Joseph A.Gardecki Adam Mauskapf Farouc A.Jaffer Guillermo J.Tearney Wellman Center for Photomedicine Harvard Medical School and Massachusetts General HospitalBostonMA 02114USA Cardiovascular Research Center and Cardiology Division Harvard Medical School and Massachusetts General HospitalBostonMA 02114USA Department of Pathology Harvard Medical School and Massachusetts General HospitalBostonMA 02114USA Harvard-MIT Division of Health Sciences and Technology CambridgeMA 02139USA

Cross-sectional visualisation of the cellular and subcellular structures of human atherosclerosis in vivo is significant,as this disease is fundamentally caused by abnormal processes that occur at this scale in a depth-dependent manner.However,due to the inherent resolution-depth of focus tradeoff of conventional focusing optics,today’s highestresolution intravascular imaging technique,namely,optical coherence tomography(OCT),is unable to provide crosssectional images at this resolution through a coronary catheter.Here,we introduce an intravascular imaging system and catheter based on few-mode interferometry,which overcomes the depth of focus limitation of conventional highnumerical-aperture objectives and enables three-dimensional cellular-resolution intravascular imaging in vivo by a submillimetre diameter,flexible catheter.Images of diseased cadaver human coronary arteries and living rabbit arteries were acquired with this device,showing clearly resolved cellular and subcellular structures within the artery wall,such as individual crystals,smooth muscle cells,and inflammatory cells.The capability of this technology to enable cellularresolution,cross-sectional intravascular imaging will make it possible to study and diagnose human coronary disease with much greater precision in the future.

关键词： arteries rabbit resolution

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A Trojan Horse for live-cell super-resolution microscopy

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Light(Science & Applications) 2020年第1期9卷 1963-1964页

作者： Gerti Beliu Markus Sauer Department of Biotechnology and Biophysics BiocenterUniversity of WürzburgAm Hubland97074 WürzburgGermany

New peptide vehicles enable the efficient live-cell labeling of intracellular organelles with cell-impermeable fluorescent probes by simple coincubation,paving the way for refined multicolor super-resolution fluoresce... 详细信息

关键词： resolution refined enable

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