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使肥胖与糖尿病联系的蛋白质Resistin

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中国生物化学与分子生物学报 2001年第4期17卷 482-482页

作者：李潇

Adipocytokine profile in children with Kawasaki disease at a mean follow-up period of 5.5 years: A study from North India

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World Journal of Clinical Pediatrics 2022年第4期11卷 360-368页

作者： Dibya Lochan Praharaj Amit Rawat Anju Gupta Kanika Arora Rakesh Kumar Pilania Sagar Bhattad Surjit Singh Pediatric Allergy and Immunology Unit Advanced Pediatrics CentrePost Graduate Institute of Medical Education and ResearchChandigarh 160012India

BACKGROUND Kawasaki disease(KD)is an acute self-limited vasculitis with a predilection for coronary arteries.Children with KD may have altered lipid metabolism and abnormal lipid profiles that may last for prolonged periods.However,there is a paucity of literature on the role of adipocytokines in KD.AIM To estimate the levels of adipocytokines(adiponectin,leptin and Resistin)during the convalescent phase of KD.METHODS Twenty children,who had KD at least three years earlier,were enrolled in this study.In addition,20 healthy controls were also enrolled.Clinical and laboratory profiles of patients were obtained from hospital records.Serum adiponectin,leptin and Resistin levels were estimated by enzyme-linked immunosorbent assay.RESULTS Mean age of the patients in the study group was 10.15±3 years and the male:female ratio was 1.5:1.Median serum Resistin levels in patients with KD(27.77 ng/mL;[IQR:18.66,48.90])were decreased compared to controls(21.20 ng/mL;[IQR:14.80,27.00])(P=0.04).Median serum leptin levels in cases and controls were 1.83 ng/mL;(IQR:1.13,3.80),and 1.10 ng/mL;(IQR:0.41,2.88),respectively(P=0.09).Median serum adiponectin levels were similar in both cases(12.20μg/mL;[IQR:9.76,17.97])and controls(13.95μg/mL;[IQR:11.17,22.58]);(P=0.18).There was no significant difference in all 3 adipocytokines between children with(4/20)and without coronary artery abnormalities(16/20).CONCLUSION Serum Resistin levels were significantly elevated in patients with KD during the convalescent phase compared to controls.Serum leptin levels appeared to be higher in patients with KD,although the difference was not statistically significant.Adiponectin levels were similar in both cases and controls.Raised Resistin and leptin levels may partially explain lipid perturbations observed during the convalescent phase of KD.

关键词： Adipocytokines Adiponectin Resistin Leptin Lipid metabolism Kawasaki disease Convalescent phase

Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer

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World Journal of Gastroenterology 2010年第10期16卷 1252-1257页

作者： Sayaka Otake Hiroaki Takeda Shoichiro Fujishima Tadahisa Fukui Tomohiko Orii Takeshi Sato Yu Sasaki Shoichi Nishise Sumio Kawata Department of Gastroenterology Yamagata University Faculty of Medicine Division of Endoscopy Yamagata University Hospital

AIM:To investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced).METHODS: A cross-sectional study in a cohort of hospital-based patients was conducted between January 2004 and March 2006 at Yamagata University Hospital. Male subjects, who had colorectal tumors detected by endoscopic examination, were enrolled according to inclusion and exclusion criteria. Based on the T factor of the TNM system, intraepithelial carcinoma and submucosally invasive carcinoma were def ined as early cancer, and invasion into the muscularis propria or deeper was defined as advanced cancer. The plasma levels of glucose, insulin, total cholesterol, triglyceride, high sensitivity C-reactive protein, insulin like growth factor (IGF)-1, IGF binding protein-3, adiponectin, leptin, and Resistin were measured. Each factor level was designated low or high, and the risk of adenoma or cancer was estimated by univariate and multivariate logistic regression analysis.RESULTS: We enrolled 124 male subjects (47 with adenoma, 34 with early cancer, 17 with advanced cancer, and 26 without tumors as controls). In patients with adenoma, high triglyceride and low adiponectin were associated with a significant increase in the odds ratio (OR) by univariate analysis. Only a low adiponectin level was related to increased adenoma risk, with an adjusted OR for low level (<11 μg/mL) to high (≥11 μg/mL) of 5.762 (95% confidence interval (CI):1.683-19.739, P=0.005). In the patients with early cancer, high body mass index, high triglyceride, and low adiponectin were associated with a significant increase in OR in univariate analysis. Imultivariate analysis, only low adiponectin was significantly associated with early cancer, with an adjusted OR of 4.495 (95% CI:1.090-18.528, P=0.038). However, in patients with advanced cancer, low adiponectin was not recognized as a significant risk factor for advanced cancer.CONCLUSION: A decreased level of adiponectin is strongly associated with an increased risk of color

关键词： Adenoma Early colorectal cancer Metabolic syndrome Adipokines Colonoscopy Resistin Leptin Body mass index

Research progress in mulberry leaf polysaccharide in treating diabetic nephropathy

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中国药理学与毒理学杂志 2021年第10期35卷 778-779页

作者： ZHANG Shi-lin JING Yong-shuai ZHANG Dan-shen ZHENG Yu-guang WU Lan-fang College of Chemistry and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018China College of Pharmacy Hebei University of Chinese MedicineShijiazhuang 050200China

Diabetic nephropathy(DN)is one of the most common complications of diabetes.It is an important cause of diabetes disability and death.DN is a systemic metabolic syndrome.In its pathogenesis,the interaction of various cell activities and a large number of cytokine biological activities,the activation of signal pathways and so on are involved in the development of DN.At present,the clinical treatment of DN is mainly Western medicine,but it has limitations such as strong toxicity,high side effects and poor compliance.Therefore,the discovery of natural anti-DN substances has also become an important means to treat DN.Mulberry leaves are the dry leaves of Morus alba L.It is not only a traditional Chinese medicine,but also a dual-purpose medicinal material for medicine and food.It has the effects of dispelling wind and clearing heat,cooling blood and brightening eyes,tonifying and so on.Mulberry leaf polysaccharide(MLP)is a kind of high molecular compound in mulberry leaves.It has many pharmacological effects,such as hypoglycemic,antioxidant,anti-stress,anti-virus and so on.Therefore,the pharmacological effects of mulberry leaf polysaccharides on diabetic nephropathy are reviewed in this paper,so as to provide references for further research and application.The pathogenesis of DN is complex,and the mechanism of renal injury has not been completely clarified.The current studies believe that DN is closely related to heredity,abnormal glucose metabolism,abnormal lipid metabolism,microcirculation disorder,cytokine action,oxidative stress and so on.Relevant studies show that the pharmacological effects of mulberry leaf polysaccharide in the prevention and treatment of DN mainly include:①Effect on transforming factor-β1(TGF-β1):TGF-β1 has become an important cytokine involved in the formation of renal fibrosis by regulating cell proliferation and differentiation and the production of extracellular matrix(ECM).MLP can significantly inhibit TGF-β1 protein,and then inhibit the synthesis of extracellular matrix by renal intersti

关键词： mulberry leaf polysaccharide diabetic nephropathy TGF-β1 insulin receptor substrate Resistin adipo⁃nectin receptor 1

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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

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Frontiers of Medicine 2007年第3期1卷 269-273页

作者： LI Yahui LI Huaixing DONG Shiyuan YU Chao JIANG Yu SUN Shuhan Institute for Nutritional Science Shanghai Institute for Biological SciencesChinese Academy of ScienceShanghai 200031China Center for Healthy Food Evaluation State Food and Drug AdministrationBeijing 100061China Department of Medical Genetics College of Basic Medical ScienceSecond Military Medical UniversityShanghai 200433China

The aim of this article was to investigate the influence and the related mechanism of the Retn gene on glucose uptake and insulin resistance in 3T3-L1 cells.Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different Retn gene expression levels,whether cells were stimulated by insulin or not.RT-PCR and real-time RT-PCR analysis were used to determine the mRNA levels of several glucose transport proteins in 3T3-L1 cells with different Retn gene expression levels,including insulin receptor substrate-1(IRS-1),phosphatidylinositol 3-kinase(PI-3K),AKT-2,glucose transporter-4(GLUT-4),p38 mitogen-activated protein kinase(p38MAPK)and glycogen synthase kinase-3b(GSK-3b).The glucose uptake decreased with the increase in Retn gene expression in 3T3-L1 cells,which was independent of whether the cells were stimulated by insulin or not.The mRNA expression of two signal proteins PI-3K and AKT-2 decreased and the other two signal proteins,GSK-3b and p38MAPK,increased with Retn overexpression in 3T3-L1 cells.Resistin could induce insulin resistance in adipocytes,which might be related to the changes of some proteins in PI-3K and Ras pathways.

关键词： Resistin Retn gene insulin glucose uptake 3T3-L1 cells

抵抗素通过P65/K8抑制HEPG2细胞中糖原的积累

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抵抗素通过P65/K8抑制HEPG2细胞中糖原的积累

作者：夏乔华中农业大学

学位级别：硕士

作为肥胖和胰岛素抵抗之间重要链接的脂肪组织特异性分泌因子抵抗素Resistin,可以降低胰岛素敏感性,抑制胰岛素刺激引起的葡萄糖摄取,其内在的机制受多种信号途径的调控。Keratin是典型的上皮细胞中间丝蛋白。作为上皮细胞骨架的组成部... 详细信息

作为肥胖和胰岛素抵抗之间重要链接的脂肪组织特异性分泌因子抵抗素Resistin,可以降低胰岛素敏感性,抑制胰岛素刺激引起的葡萄糖摄取,其内在的机制受多种信号途径的调控。Keratin是典型的上皮细胞中间丝蛋白。作为上皮细胞骨架的组成部分,Keratin不仅在维持上皮细胞和组织的稳定与完整性方面起着重要作用。而且一些Keratins还具有调节功能参与细胞信号通路的调控,在癌症诊断中可作为标志物,在临床应用中发挥重要作用。研究发现,作为Keratin家族重要一员的Keratin 8在糖代谢方面也发挥着重要作用。在小鼠正常肝细胞和肝癌细胞中敲除K8/K18后,能促进细胞中胰岛素刺激引起的葡萄糖积累,但其机制并不清楚,尤其是Keratin 8介导的Resistin对糖代谢的影响。本文通过实时荧光定量PCR、双荧光素酶报告系统检测及染色质免疫共沉淀等方法较系统的研究了HepG2细胞中Keratin 8对糖代谢的影响及Resistin对Keratin 8基因表达的调控作用。获得如下结果：1、细胞瞬时转染和基因敲减结果证明,Resistin抑制HepG2细胞中糖原的积累,敲减Keratin 8能够促进糖原的积累,同时能回复Resistin对糖原积累的抑制作用。2、生物信息学方法分析表明,Keratin 8基因启动子区具有典型的p65结合元件。双荧光素酶报告系统及ChIP实验分析证明,p65可与Keratin 8启动子特异结合上调Keratin 8的转录表达。3、不同浓度重组Resistin处理HepG2细胞发现,Resistin可显著抑制肝糖原的积累,这种作用是Resistin通过p65信号途径调控K8的转录表达,以抑制肝糖原的积累。简而言之,在HepG2细胞中,Resistin可以通过上调p65/K8抑制细胞中糖原的积累;且p65可与K8的启动子直接结合,调节K8的转录表达,进而调节糖代谢。

关键词： HepG2 Resistin Keratin 8 p65 糖原积累

Resistin促进内皮细胞活化进一步说明脂肪细胞因子—内皮之间相互作用的证据

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岭南心血管病杂志 2003年第6期9卷 455-455页

作者： Subodh Verma

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Resistin:联系肥胖病与2型糖尿病的纽带

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国际内分泌代谢杂志 2001年第3期 168-168页

Saliva as a non-invasive diagnostic tool for inflammation and insulin-resistance

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World Journal of Diabetes 2014年第6期5卷 730-738页

作者： Gauri S Desai Suresh T Mathews Department of Nutrition and Dietetics Boshell Diabetes and Metabolic Diseases Research ProgramAuburn University

Saliva has been progressively studied as a non-invasive and relatively stress-free diagnostic alternative to blood. Currently, saliva testing is used for clinical assessment of hormonal perturbations, detection of HIV antibodies, DNA analysis, alcohol screening, and drug testing. Recently, there has been increasing interest in evaluating the diagnostic potential of saliva in obesity, inflammation, and insulin-resistance. Current literature has demonstrated elevated levels of inflammatory biomarkers including C-reactive protein, tumor necrosis factor-α, interleukin-6, and interferon-γ in saliva of obese/overweight children and adults. Salivary antioxidant status has also been studied as a measure of oxidative stress in individuals with type 2 diabetes. Further, several studies have demonstrated correlations of salivary markers of stress and insulin resistance including cortisol, insulin, adiponectin, and Resistin with serum concentrations. These findings suggest the potential diagnostic value of saliva in health screening and risk stratification studies, particularly in the pediatric population, with implications for inflammatory, metabolic and cardiovascular conditions. However, additionalstudies are required to standardize saliva collection and storage procedures, validate analytical techniques for biomarker detection, and establish reference ranges for routine clinical use. The purpose of this review is to summarize and evaluate recent advancements in using saliva as a diagnostic tool for inflammation and insulinresistance.

关键词： salivary inflammation diagnostic screening Resistin progressively pediatric routine obesity interferon