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Acta Pharmaceutica Sinica B 2021年第5期11卷 1200-1212页

作者： Yuyu Zhu Ning Wan Xinni Shan Guoliang Deng Qiang Xu Hui Ye Yang Sun State Key Laboratory of Pharmaceutical Biotechnology Department of Biotechnology and Pharmaceutical SciencesSchool of Life SciencesNanjing UniversityNanjing 210023China Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Chemistry and Biomedicine Innovation Center(ChemBIC) Nanjing UniversityNanjing 210023China

Metabolic syndrome is a clustering of metabolic disorder with unclear molecular mechanism.Increasing studies have found that the pathogenesis and progression of metabolic syndrome are closely related to inflammation.Here,we report celastrol,a traditional Chinese medicine,can improve high fat diet-induced metabolic syndrome through suppressing Resistin-induced inflammation.Mechanistically,celastrol binds to adenylyl cyclase associated protein 1(CAP1)and inhibits the interaction between CAP1 and Resistin,which restrains the cyclic adenylate monophosphate(cAMP)-protein kinase A(PKA)-nuclear factor kappa-B(NF-kB)signaling pathway and ameliorates high fat diet-induced murine metabolic syndrome.Knockdown of CAP1 in macrophages abrogated the Resistin-mediated inflammatory activity.In contrast,overexpression of CAP1 in macrophages aggravated inflammation.Taken together,our study identifies celastrol,which directly targets CAP1 in macrophages,might be a promising drug candidate for the treatment of inflammatory metabolic diseases,such as metabolic syndrome.

关键词： Metabolic syndrome Celastrol CAP1 Resistin Inflammation

抵抗素(Resistin)与胰岛素抵抗现象

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第四军医大学学报 2002年第16期23卷 1533-1535页

作者：赵蓓赵伯钦第四军医大学学员旅十二队陕西西安710033 第四军医大学西京医院内分泌科陕西西安710033

糖尿病是一种慢性疾病 ,可以导致心 ,脑 ,肾 ,眼和神经损害等合并症 . 型糖尿病的主要特征是胰岛素的抵抗现象 ,且与肥胖关系密切 ;但是肥胖引起胰岛素抵抗的机制一直不清楚 .一种由脂肪细胞分泌的多肽类激素 ,被命名为抵抗素 (resisti... 详细信息

糖尿病是一种慢性疾病 ,可以导致心 ,脑 ,肾 ,眼和神经损害等合并症 . 型糖尿病的主要特征是胰岛素的抵抗现象 ,且与肥胖关系密切 ;但是肥胖引起胰岛素抵抗的机制一直不清楚 .一种由脂肪细胞分泌的多肽类激素 ,被命名为抵抗素 (Resistin) .血中的抵抗素可被降糖药物罗格列酮下调 ,而在饮食性或遗传性肥胖则呈现升高 .在肥胖鼠中抗抵抗素抗体可以改善血糖和胰岛素作用 .在正常鼠中 ,重组抵抗素可以损害葡萄糖耐量和胰岛素活性 .用抗体中和抵抗素可以促进脂肪细胞对葡萄糖的摄取 ,而抵抗素则可使之下降 .抵抗素可以很好地解释胰岛素抵抗。

关键词：抵抗素 Resistin 胰岛素抵抗糖尿病

Analysis on Correlation between Resistin—420C/G Polymorphism and Type 2 Diabetes Mellitus Macroangiopathy in Han Population of Northeast China

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Journal of Biosciences and Medicines 2017年第12期5卷 17-23页

作者： Bingxue Qi Ma Yan Yadong Sun Department of Endocrinology People’s Hospital of Jilin Province Changchun China

Objective: To study the allelic and genotypic frequency distribution of RETN—420C/G single nucleotide polymorphisms (SNPs) and its relationship with type 2 diabetes mellitus (T2DM) complicated with macroangiopathy in Han population of northeast China. Methods: The genotypes and their frequencies of a total of 180 cases, including 60 cases of T2DM complicated with macroangiopathy, 60 cases of simple T2DM and 60 cases of normal control (ND), were measured by PCR—RFLP. Results: The allelic frequencies and simple CC/GC + GG genotype in T2DM complicated with macroangiopathy group were significant different compared with ND group (P Conclusion: The RETN—420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.

关键词： Type 2 Diabetes Mellitus Resistin Gene Polymorphism Macroangiopathy Polymerase Chain Reaction

人和小鼠Resistin基因的克隆与序列测定

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生物技术通讯 2002年第3期13卷 173-175页

作者：詹林盛王会中彭剑淳王全立军事医学科学院输血研究所北京100850

构建人和小鼠Resistin基因cDNA克隆,并进行序列分析,为进一步进行Resistin表达和生物学活性研究奠定基础。用RT-PCR方法扩增人和小鼠Resistin基因cDNA,获得的片段连接至pGEM-T载体,转化大肠杆菌JM109,并经过酶切鉴定和序列测定。结果成... 详细信息

构建人和小鼠Resistin基因cDNA克隆,并进行序列分析,为进一步进行Resistin表达和生物学活性研究奠定基础。用RT-PCR方法扩增人和小鼠Resistin基因cDNA,获得的片段连接至pGEM-T载体,转化大肠杆菌JM109,并经过酶切鉴定和序列测定。结果成功地构建了人和小鼠Resistin基因cDNA克隆,人和小鼠Resistin的氨基酸序列具有共同的结构特征CX28CX12CX8CXCX3CX10CXCXCX9CC,克隆的人ResistincDNA在编码序列第133位的A被T代替,导致45位密码子编码的丝氨酸由半胱氨酸代替;小鼠ResistincDNA在第16位的T被C取代,导致第6位密码子编码的苯丙氨酸改变为亮氨酸。密码子发生改变的生物学意义还有待于进一步研究。

关键词：人小鼠 Resistin 基因克隆序列分析脂肪组织

The Relationship between Serum 25-Hydroxyvitamin D and Resistin Levels in Saudi Diabetic Patients

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Open Journal of Endocrine and Metabolic Diseases 2016年第2期6卷 102-108页

作者： Ahmed El-Tahir Abdulaziz F. AL-Kaabbab Muaawia Ahmed Hamza Abdullah A. Saeed Abdulshakour Abdalla May F. AlMohareb Hana S. Alfaleh Gwiria M. H. Satti Faculty of Medicine King Fahad Medical City Ministry of Health Kingdom of Saudi Arabia Faculty of Medicine Al-Imam Mohammed Ibn Saud Islamic University Kingdom of Saudi Arabia Faculty of Medicine University of Khartoum Sudan

Objectives: The aim of this study was to investigate the relationship between the levels of 25-hydroxyvitamin D and the adipokine Resistin in Saudi diabetic patients and those at high risk to develop atherosclerotic cardiovascular diseases. Methodology: One hundred and sixty seven subjects were recruited for the cross-sectional study at King Fahad Medical City, Saudi Arabia. Blood samples were analyzed for biochemical parameters. Serum 25-hydroxyvitamin D and Resistin levels were measured for all the participants. Result: Fifty six type-1, 55 type-2 diabetic patients and 56 healthy controls were recruited. Serum 25-hydroxyvitamin D level in the control group was 44.21 ± 41.80 μg/ml compared to 50.67 ± 35.60 μg/ml in the diabetic group (P = 0.427) with no significant different between type-2 diabetes mellitus and type-1 diabetes mellitus (P = 0.628). Resistin level in the control group was 14.00 ± 7.39μg/ml compared to 20.21 ± 16.94 μg/ml in the diabetic group (P ≤ 0.01), no significant difference between type-2 diabetes mellitus and type-1 diabetes mellitus (P = 0.817). Resistin in those taking vitamin D supplementation was 21.34 ± 18.27 μg/ml;and in those not taking vitamin D supplementation, it was 17.4 ± 11.19 μg/ml;(P = 0.237). There was significant negative correlation between 25-hydroxyvitamin D and Resistin in type-2 diabetes mellitus (P ≤ 0.043) and no significant correlation was found between vitamin 25 (OH) D and Resistin level in type-1 diabetes mellitus (P = 0.538). Blood urea and creatinine showed significant positive correlation with vitamin 25 (OH) D in one hand and Resistin level on the other hand. Discussion and Conclusions: Several in vitro and in vivo studies have confirmed that the vitamin 25 (OH) D have numerous important functions in the body. The circulating vitamin 25 (OH) D and Resistin levels were associated with general inflammation in renal diseases. This study showed significant negative correlation between Resistin level and vitamin 25 (OH) D in type 2 diabetes mellitus reflecting th

关键词： 25-Hydroxyvitamin D Resistin Diabetes Mellitus Kingdom of Saudi Arabia

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新激素Resistin联系糖尿病与肥胖

岭南心血管病杂志 2003年第6期9卷 455-456页

Serum Resistin Level and Polymorphonuclear Leukocytes Dysfunctions in Children on Regular Hemodialysis

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International Journal of Clinical Medicine 2015年第6期6卷 423-430页

作者： Maha Yousef Zein Manal Abdel-Salam Iman Abdel-Aziz Naglaa Fathy Mohamed Department of Pediatrics Faculty of Medicine (Girls) Al-Azhar University Cairo Egypt Department of Clinical and Chemical Pathology Theodor Bilharz Research Institute Cairo Egypt

Resistin is a secretory adipocytoine, which is expressed mainly in humans by inflammatory cells especially macrophages. Resistin serum levels are elevated in end-stage renal diseases of people having an increased risk of infections as a result of impaired polymorphonuclear leukocytes (PMNLs) functions. Objectives: To evaluate neutrophil functions (phagocytosis and oxidative burst) in children with end-stage renal disease (ESRD) on regular hemodialysis and to shed light on the contribution of Resistin on neutrophil functions. Patients and Methods: The study included 40 children with ESRD on regular hemodialysis. Their ages ranged from 6 to 12 years, and they were selected from children attending the pediatric hemodialysis unit of AL-Zahraa Hospital, Al-Azher University during the period from October 2012 to December 2013. Another group of 40 apparently healthy children with matched age and sex with the patient group served as a control. Serum Resistin, phagocytic index and nitro blue tetrazolium test (NBT%) were assessed in both groups. Results: There was a statistically more significant increase in Resistin serum levels in cases than in controls;it was (3.25 ± 0.86 ng/ml) and (0.25 ± 0.16 ng/ml) respectively

关键词： Chronic Kidney Disease Resistin Dialysis Polymorphonuclear Leukocytes

Clinical Implications of Tumor Necrosis Factor-Alpha, Interleukin-6 and Resistin in Coronary Artery Disease

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World Journal of Cardiovascular Diseases 2014年第9期4卷 416-421页

作者： Qamar Javed Department of Biochemistry Quaid-i-Azam University Islamabad Pakistan

Tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) are involved in the progression of coronary artery disease (CAD). The cytokines’ levels are associated with the severity of CAD. We have recently reported on the association of Resistin, a relatively novel cytokine with the pathogenesis of cardiovascular disease (CVD). Although the inflammatory cytokines’ impact on atherosclerosis is widely accepted, yet some controversy exists regarding the involvement of these factors in atherogenesis. The current review highlights the potential association of TNF-alpha, IL-6 and Resistin SNPs (single nucleotide polymorphisms) with CAD. Molecular genetics data along with the intracellular signaling cascade mechanisms may have important clinical implications in the treatment of CAD.

关键词： Tumor Necrosis Factor-Alpha Interleukin-6 Resistin Coronory Heart Disease Gene Polymorphism

Resistin——肥胖与糖尿病的主要连结点?

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中华内分泌代谢杂志 2001年第5期17卷 267-267页

作者：陈名道上海第二医科大学附属瑞金医院上海市内分泌研究所200025

目的建立扩展高胰岛素-正葡萄糖钳夹技术.方法应用扩展葡萄糖钳夹技术(即联合葡萄糖钳夹、3-3H标记葡萄糖示踪技术及间接测热技术)对9例正常体重、正常糖耐量者进行方法学研究.结果 (1)在优势浓度胰岛素、血浆葡萄糖稳定在正常水平状态... 详细信息

目的建立扩展高胰岛素-正葡萄糖钳夹技术.方法应用扩展葡萄糖钳夹技术(即联合葡萄糖钳夹、3-3H标记葡萄糖示踪技术及间接测热技术)对9例正常体重、正常糖耐量者进行方法学研究.结果 (1)在优势浓度胰岛素、血浆葡萄糖稳定在正常水平状态下肝糖产生完全被抑制,未见到升糖激素(皮质醇、生长激素、胰高血糖素)显著兴奋及内源性胰岛素释放.(2)扩展高胰岛素-正葡萄糖钳夹稳态期,胰岛素介导的机体葡萄糖利用率(葡萄糖消失率)较基础状态显著增加[(5.86±0.65)mg*kg-1*min-1比(2.45±0.15)mg*kg-1*min-1,P＜0.01],并以糖原合成为主;脂肪氧化被显著抑制,游离脂肪酸浓度显著下降.结论扩展高胰岛素-正葡萄糖钳夹技术已成功建立;在外源性胰岛素-葡萄糖代谢的稳定状态下,机体对葡萄糖利用显著增加,脂肪分解显著减少.

关键词：肥胖糖尿病病因 Resistin 激素

Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis

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World Journal of Gastroenterology 2015年第10期21卷 3020-3029页

作者： Maria Kalafateli Christos Triantos Emmanuel Tsochatzis Marina Michalaki Efstratios Koutroumpakis Konstantinos Thomopoulos Venetsanea Kyriazopoulou Eleni Jelastopulu Andrew Burroughs Chryssoula Lambropoulou-Karatza Vasiliki Nikolopoulou Department of Gastroenterology University Hospital of Patras The Royal Free Sheila Sherlock Liver Centre Royal Free Hospital Department of Endocrinology University Hospital of Patras Department of Public Health Medical SchoolUniversity of Patras Department of Internal Medicine University Hospital of Patras

AIM:To investigate the adipokine levels of leptin,adiponectin,Resistin,visfatin,retinol-binding protein 4(RBP4),apelin in alcoholic liver cirrhosis(ALC).METHODS:Forty non-diabetic ALC patients[median age:59 years,males:35(87.5%),Child-Pugh(CP)score:median 7(5-12),CP A/B/C:18/10/12,Model for End-stage Liver Disease(MELD):median 10(6-25),follow-up:median 32.5 mo(10-43)]were prospectively included.The serum adipokine levels were estimated in duplicate by ELISA.Somatometric characteristics were assessed with tetrapolar bioelectrical impedance analysis.Pearson’s rank correlation coefficient was used to assess possible associations with adipokine levels.Univariate and multivariate Cox regression analysis was used to determine independent predictors for overallsurvival.RESULTS:Body mass index:median 25.9(range:20.1-39.3),fat:23.4%(7.6-42.1),fat mass:17.8(5.49-45.4),free fat mass:56.1(39.6-74.4),total body water(TBW):40.6(29.8-58.8).Leptin and visfatin levels were positively associated with fat mass(P<0.001/P=0.027,respectively)and RBP4 with TBW(P=0.025).Median adiponectin levels were significantly higher in CPC compared to CPA(CPA:7.99±14.07,CPB:7.66±3.48,CPC:25.73±26.8,P=0.04),whereas median RBP4 and apelin levels decreased across the spectrum of disease severity(P=0.006/P=0.034,respectively).Following adjustment for fat mass,visfatin and adiponectin levels were significantly increased from CPA to CPC(both P<0.001),whereas an inverse correlation was observed for both RBP4 and apelin(both P<0.001).In the multivariate Cox regression analysis,only MELD had an independent association with overall survival(HR=1.53,95%CI:1.05-2.32;P=0.029).CONCLUSION:Adipokines are associated with deteriorating liver function in a complex manner in patients with alcoholic liver cirrhosis.

关键词： Adipokines Adiponectin Cirrhosis Leptin Resistin