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Measuring episodic abdominal pain and disability in suspected sphincter of Oddi dysfunction

World Journal of Gastroenterology 2010年第35期16卷 4416-4421页

作者： Valerie Durkalski Walter Stewart Paulette MacDougall Patrick Mauldin Joseph Romagnuolo Olga Brawman-Minzter Peter Cotton Division of Biostatistics and Epidemiology Medical University of South Carolina Center for Health Research Geisinger Health System Digestive Diseases Center Medical University of South Carolina Department of Pharmacy Medical University of South Carolina Department of Psychiatry Medical University of South Carolina

AIM:To evaluate the reliability of an instrument that measures disability arising from episodic abdominal pain in patients with suspected sphincter of Oddi dysfunction(SOD).METHODS:Although several treatments have been utilized to reduce pain and associated disability,measurement tools have not been developed to reliably track *** pilot studies were conducted to assess test-retest reliability of a newly developed instrument,the recurrent abdominal pain intensity and disability(RAPID) *** RAPID score is a 90-d summation of days where productivity for various daily activities is reduced as a result of abdominal pain episodes,and is modeled after the migraine disability assessment instrument used to measure headache-related *** was administered by telephone on 2 consecutive occasions in 2 consenting populations with suspected SOD:a pre-sphincterotomy population(Pilot Ⅰ,n = 55) and a post-sphincterotomy population(Pilot Ⅱ,n = 70).results:The average RAPID scores for Pilots Ⅰ and Ⅱ were:82 d(median:81.5 d,SD:64 d) and 48 d(median:0 d,SD:91 d),*** concordance between the 2 assessments for both populations was very good:0.81 for the pre-sphincterotomy population and 0.95 for the post-sphincterotomy ***:The described pilot studies suggest that RAPID is a reliable instrument for measuring disability resulting from abdominal pain in suspected SOD patients.

关键词： Sphincter of Oddi Abdominal pain Disability measurement reproducibility of results Pain measurement Episodic pain

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Development and evaluation of short form of constitution in Chinese medicine questionnaire:a national epidemiological survey data of 21948 cases

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Journal of Traditional Chinese Medicine 2022年第1期42卷 122-131页

作者： BAI Minghua WONG Wendy HOU Shujuan ZHENG Yanfei LI Qianru LI ZhuQing ZHANG Yan LI Lingru WANG Ji WANG Qi School of Traditional Chinese Medicine/National Institute of TCM Constitution and Preventive Medicine Beijing University of Chinese MedicineBeijing 100029China School of Chinese Medicine Hong Kong Institute of Integrative MedicineChinese University of Hong KongHong Kong SAR 852China National Institute of TCM Constitution and Preventive Medicine Beijing University of Chinese MedicineBeijing 100029China

OBJECTIVE:To develop the best short form of constitution in Chinese medicine questionnaire(CCMQ)and evaluate its psychometric properties in Chinese ***:A total of 21948 subjects were used to refine the short *** coefficient,exploratory factor analysis(EFA)and Cronbach's alpha coefficient were used to analyze and select items to form the short *** sample of 205 subjects were collected to further evaluate the short ***,confirmatory factor analysis(CFA),item-scale correlation,discriminant validity,internal consistency reliability and split-half reliability were carried out to evaluate the short ***:The short form CCMQ included 26 *** common factors of characteristic root>1 were extracted to explain 58.488%of the total *** of CFA was consistent with the 9-factors *** mean differences of Blood-stasis body constitution and Qi-stagnation body constitution had statistical significance in body mass index ***'s alpha coefficient of short form CCMQ was *** split-half reliability of total scale was 0.813,and each scale was *** item-scale correlations ranged from ***:The short form CCMQ consisted of 26 items with good psychometric *** short form should be recommended for the measurement of health of Chinese population in any clinical trial.

关键词： constitution in Chinese medicine questionnaire form scale evaluation reproducibility of results

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Is laparoscopy an advantage in the diagnosis of cirrhosis in chronic hepatitis C virus infection?

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World Journal of Gastroenterology 2003年第4期9卷 745-750页

作者： Perdita Wietzke-Braun Felix Braun Peter Schott Giuliano Ramadori Department of Internal Medicine Division of Gastroenterology and EndocrinologyUniversity of GoettingenGermany

AIM:To evaluate the potential of laparoscopy in the diagnosis of cirrhosis and outcome of interferon treatment in HCV-infected patients. METHODS:In this retrospective study,diagnostic laparoscopy with laparoscopic liver biopsy was performed in 72 consecutive patients with chronic HCV *** presence or absence of drrhosis was analyzed macroscopically by laparoscopy and microscopically by liver biopsy *** and laboratory data and outcome of interferon-alfa treatment were compared between cirrhotic and noncirrhotic patients. results:Laparoscopically,cirrhosis was seen in 29.2 % (21/72)and non-cirrhosis in 70.8 %(51/72)of patients. Cirrhotic patients were significantly older with a significant longer duration of HCV infection than noncirrhotic patients. Laboratory parameters(AST,y-GT,y-globulin fraction)were measured significantly higher as well as significantly lower (prothrombin index,platelet count)in cirrhotic patients than in non-cirrhotic ***,cirrhosis was confirmed in 11.1%(8/72)and non cirrhosis in 88.9 %(64/72).Patients with macroscopically confirmed cirrhosis(n=21)showed histologically cirrhosis in 38.2 %(8/21)and histologically non- cirrhosis in 61.9 %(13/21).In contrast,patients with macroscopically non-cirrhosis(n=51)showed histologically non cirrhosis in all cases(51/51).Thirty-nine of 72 patients were treated with interferon-alfa,resulting in 35.9 %(14/39) patients with sustained response and 64.1%(25/39)with non ***-responders showed significantly more macroscopically cirrhosis than sustained *** contrast,there were no significant histological differences between non-responders and sustained responders. CONCLUSION:Diagnostic laparoscopy is more accurate than liver biopsy in recognizing cirrhosis in patients with chronic HCV *** biopsy is the best way to assess inflammatory grade and fibrotic *** invasive marker for staging,prognosis and management,and treatment outcome of chro

关键词： Adult Biopsy Comparative Study Female Genotype Hepacivirus purification Hepatitis C, Chronic Humans Interferon-alpha Laparoscopy Liver Cirrhosis Male Middle Aged RNA, Viral reproducibility of results Retrospective Studies Treatment Outcome

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Serum positive cagA in patients with non-ulcer dyspepsia and peptic ulcer disease from two centers in different regions of Turkey

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World Journal of Gastroenterology 2003年第4期9卷 833-835页

作者： Ender Serin Uur Yilmaz Ganiye Künefeci Birol zer Yüksel Gümürdülü Mustafa Gülü Fazilet Kayaseluk Sedat Boyaciolu Ba kent University Faculty of Medicine Department of GastroenterologyAdana Teaching and Medical Research CenterDadalolu Mahallesi39 SokakNo:601250 AdanaTurkey Ba■kent University Faculty of Medicine Department of GastroenterologyAnkara HospitalDadalolu Mahallesi39 SokakNo:601250 AdanaTurkey Ba■kent University Faculty of Medicine Department of PathologyAdana Teaching and Medical Research Center Dadalolu Mahallesi39 SokakNo:601250 AdanaTurkey

AIM: To investigate and compare frequencies of serum positive cagA in patients from two separate regions of Turkey who were grouped according to the presence of peptic ulcer disease or non-ulcer ***: One hundred and eighty Helicobacter pyloripositive patients with peptic ulcer disease or non-ulcer dyspepsia were included in the study. One hundred and fourteen patients had non-ulcer dyspepsia and 66 had peptic ulcer disease (32 with gastric ulcers and/or erosions and 34with duodenal ulcers). Each patient was tested for serum antibody to H. pylori cagA protein by enzyme ***: The total frequency of serum positive cagA in the study group was 97.2 %. The rates in the patients with peptic ulcers and in those with non-ulcer dyspepsia were 100% and 95.6%, respectively. These results were similar to those reported in Asian studies, but higher than those that have been noted in other studies from Turkey and Western ***: The high rates of serum positive cagA in these patients with peptic ulcer disease and non-ulcer dyspepsia were similar to results reported in Asia. The fact that there was high seroum prevalence regardless of ulcer status suggests that factors other than cagA might be responsible for ulceration or other types of severe pathology in H. pylori-positive individuals.

关键词： Helicobacter pylori Adult Biological Markers Dyspepsia Female Gastric Mucosa Helicobacter Infections Humans Male Peptic Ulcer reproducibility of results Turkey Urease

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Influencing factors of rat small intestinal epithelial cell cultivation and effects of radiation on cell proliferation

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World Journal of Gastroenterology 2001年第1期7卷 140-142页

作者： Xin Ze Ran Yong Ping Su Yong Jiang Wei Guo Ping Ai Tian Min Cheng Yuan Lin Institute of Combined Injury, PLA, School of Preventive Medicine, Third Military Medical University. Chongqing 400038, China Institute of Combined Injury PLA School of Preventive Medicine Third Military Medical University Chongqing 400038 China. rxz@***

INTRODUCTIONCrypt epithelial cells in normal small intestineproliferate at a high speed. But they are verydifficult to culture in vitro and passage stably. A lotof studies have been done[1-16]. Some domestic labsisolated and cultured crypt cells from embryonalintestines and aseptic animal intestine, but *** introduced normal rat epithelial cell line-IEC-6from the USA and its living condition for stablepassage was successfully established after trials. Thecell line was testified to be the small intestinalepithelial cell by electron microscopy,immunihistochemistry and enzymatic histoch-emistry. It has been applied to some relatedresearch work[17-21]. It was found that manyfactors were involved in the culture system. Ourpresent study focuses on the culture method and theinfluencing factors on IEC-6.

关键词： Animals Blood Proteins Cell Count Cell Culture Techniques Cell Division Cell Line Culture Media Dose-Response Relationship, Radiation Fetal Proteins Hydrogen-Ion Concentration Hypoglycemic Agents Insulin Intestinal Mucosa Intestine, Small Radiation, Ionizing Rats reproducibility of results Research Support, Non-U.S. Gov't Thymidine Tritium

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Chronic liver disease questionnaire:Translation and validation in Thais

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World Journal of Gastroenterology 2004年第13期10卷 1954-1957页

作者： Abhasnee Sobhonslidsuk ChatchawanSilpakit RonnachaiKongsakon PatchareeyaSatitpornkul ChaleawSripetch Department of Medicine Ramathibodi HospitalMahidoi UniversityBangkok10400Thailand Department of Psychiatry Ramathibodi HospitalMahidol UniversityBangkok10400Thailand Department of Medicine Ramathibodi HospitalMahidol UniversityBangkok10400Thailand

AIM:Quality of life (QOL) is a concept that incorporates many aspects of life beyond“health”.The chronic liver disease questionnaire (CLDQ) was developed to evaluate the impact of chronic liver diseases (CLD) on *** objectives of this study were to translate and validate a liver specific questionnaire,the CLDQ. METHODS:The CLDQ was formally translated from the original version to Thai language with *** translation process included forward translation,back translation,cross-cultural adaptation and a *** and validity of the translated version was examined in CLD *** subjects included CLD and normal subjects with age- and *** data were demography, physical findings and biochemical *** subjects were asked to complete the translated versions of CLDQ and SF- 36,which was previously ***'s alpha and test-retest were performed for reliability ***-way Anova or non-parametric method was used to determine discriminant ***'s rank correlation was used to assess convergent validity.P-valueresults:A total of 200 subjects were recruited into the study,with 150 CLD and 50 normal *** ages (SD) were 47.3(11.7) and 49.1(8.5) years,*** number of chronic hepatitis:cirrhosis was 76:74,and the ratio of cirrhotic patients classified as Child A:B:C was 37 (50%):26(35%):11(15%).Cronbach's alpha of the overall CLDQ scores was 0.96 and of all domains were higher than ***-total correlation was>***-retest reliability done at 1 to 4 wk apart was 0.88 for the average CLDQ score and from 0.68 to 0.90 for domain *** CLDQ was found to have discriminant *** highest scores of CLDQ domains were in the normal group,scores were lower in the compensated group and lowest in the decompensated *** significant correlation between domains of the CLDQ and SF-36 was *** average CLDQ score was strongly

关键词： Quality of Life Translations Adult Chronic Disease Female Humans Liver Diseases Male Middle Aged Questionnaires reproducibility of results Research Support, Non-U.S. Gov't Severity of Illness Index Thailand

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A Design of 2-Stage Voltage Ramp-Up SRAM Physical Unclonable Function

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Chinese Journal of Electronics 2024年第2期33卷 371-379页

作者： Minte SONG Nan LIU Shuaiyang ZHOU Zhengguang WANG Zhanqiang RU Peng DING Wei HUANG Helun SONG School of Nano-Tech and Nano-Bionics University of Science and Technology of China Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences

Silicon physical unclonable function（PUF） implemented by static random access memory（SRAM）exists inherent demerit of unstable cells due to noise of environment and circuits, which significantly restricts its reproducibility. In this paper, a 16T SRAM cell with reset-delay circuit and a 2-stage voltage ramp up is fabricated and reported. Compared to conventional SRAM structure, each PUF cell adds a pair of pull-up PMOS（P-channel metal oxide semiconductor） and pull-down NMOS（N-channel metal oxide semiconductor） controlled by reset and delayedreset signals respectively, resulting in two positive feedback stages with different amplification coefficients when the voltage is ramped up. PUF array consists of 4064 cells, 322 dummy cells and a group of 8 series-connected inverters with an area of 304 μm × 650 μm to match the digital post-processing module. PUF test chip was fabricated in HHGrace 110 nm platform with total area 1140 × 1140 μm2. The average HDintra（intra-chip Hamming distance, also bit error rate, BER） and HDinter（inter-chip Hamming distance） values of the 50 PUF chips in SOP16 package measured at normal point（1.5 V/25 ℃） were 1.92% and 49.85%, respectively.

关键词： Semiconductor device measurement Circuits Bit error rate Metals Aging Physical unclonable function reproducibility of results

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A 3D-printable device allowing fast and reproducible longitudinal preparation of mouse intestines

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Animal Models and Experimental Medicine 2022年第2期5卷 189-196页

作者： Beckey DeLucia Sergey Samorezov Megan T.Zangara Rachel L.Markley Lucas J.Osborn Karlee B.Schultz Christine McDonald Jan Claesen Department of Cardiovascular and Metabolic Sciences Lerner Research InstituteCleveland ClinicClevelandOhioUSA Center for Microbiome and Human Health Lerner Research InstituteCleveland ClinicClevelandOhioUSA Department of Biomedical Engineering Lerner Research InstituteCleveland ClinicClevelandOhioUSA Department of Molecular Medicine Cleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityClevelandOhioUSA Department of Inflammation and Immunity Lerner Research InstituteCleveland ClinicClevelandOhioUSA College of Arts and Sciences John Carroll UniversityUniversity HeightsOhioUSA

Accurate and reproducible analysis of murine small and large intestinal tissue is key for preclinical models involving intestinal ***,there is no easily ac-cessible,standardized method that allows researchers of different skill levels to con-sistently dissect intestines in a time-efficient ***,we describe the design and use of the 3D-printed“Mouse Intestinal Slicing Tool”(MIST),which can be used to longitudinally dissect murine intestines for further *** benchmarked the MIST against a commonly used procedure involving scissors to make a longitudinal cut along the *** of the MIST halved the time per mouse to prepare the intestines and outperformed alternative methods in smoothness of the cutting edge and overall *** sharing the plans for printing the MIST,we hope to contribute a uniformly applicable method for saving time and increasing consistency in studies of the mouse gastrointestinal tract.

关键词： adenoma dissection i ntestines mice printing three-dimensional reproducibility of results

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Acrylic Customized X-Ray Positioning Stent for Prospective Bone Level Analysis in Long-Term Clinical Implant Studies

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Open Journal of Radiology 2013年第3期3卷 136-142页

作者： Ana Messias Joao Paulo Tondela Salomao Rocha Rita Reis Pedro Nicolau Fernando Guerra Department of Dentistry Faculty of MedicineUniversity of CoimbraCoimbraPortugal

Objectives: This paper describes a technique to produce individualized X-ray positioning devices for intraoral digital imaging of dental implants with long-term stability. Materials and Methods: An X-ray positioning device was built for Gendex? Visualix? eHD sensor, using the Dentsply rinn XCP-DS? system individualized by the incorporation of the bite piece within an acrylic stent to perform successive standardized radiographs to 16 patients. X-ray tube stabilization was achieved with polivinylsiloxane. Series of 3 radiographs were taken to each patient in different moments. Specific linear measurements as the implant diameter (mesio-distal width) and the height between consecutive threads (thread pitch) were made to all radiographs to determine the reproducibility and accuracy of the procedure. results: The intraclass correlation coefficient for the mesio-distal width was 0.964 [(0.920 - 0.986) 95% CI] (p 0.00156 mm for the test value of 3.3 (p = 0.9), -0.00026 mm for 0.8 (p = 0.96) and 0.0124 for 4.125 (p = 0.72), respectively, after the application of a magnification correction factor. Conclusion: The device produced reproducible images in different moments and was suitable for comparative clinical examinations of marginal bone as it was convenient to perform reliable linear measurements.

关键词： Dental Radiovisiography Radiograph Dental Implant Outcome Measurement Errors reproducibility of results

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Evaluation of the reliability and validity of the modified Morisky scale for patient's compliance with moxibustion

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Journal of Acupuncture and Tuina Science 2017年第3期15卷 199-203页

作者：王祥杨惠余常吴巧凤唐勇余曙光洪珏 School of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineSichuan 610075China 不详

Objective： A questionnaire for the compliance with moxibustion was designed based on the 4-item Morisky scale, and the reliability and validity of the questionnaire was investigated. Methods： A modified Morisky scale was designed based on the 4-item Morisky scale for the compliance with moxibustion, and 146 patients having received moxibustion for over 2 weeks were investigated using this scale to evaluate their compliance with moxibustion; the internal equity and the construct validity of the scale were statistically analyzed. results： The analysis of reliability showed that in item of internal consistency, the Cronbach＇s α was 0.72 and the split-half coefficient was 0.71, the correlation coefficients between the 4 component scores and the total score ranged 0.67-0.80, and the between-component correlation coefficients ranged 0.24-0.56; the exploratory factor analysis（EFA） totally extracted 1 common factor, and the explicable variation was 55.02%, and the loads of the 4 items were respectively 0.82, 0.81, 0.74 and 0.58. Conclusion： The reliability and validity of the modified Morisky scale for the compliance with moxibustion are acceptable, while several items need further modification and improvement in the expression and content.

关键词： Moxibustion Therapy Moxa Cone Moxibustion Moxa Stick Moxibustion Compliance Surveys and Questionnaires Modified Morisky Scale reproducibility of results

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