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Changes in renal excretion pathways in rats with adenine-induced chronic renal failure

Journal of Chinese Pharmaceutical Sciences 2021年第4期30卷 319-333页

作者： Yanrong Ma Mingyan Xin Juanli Wu Dangju Wang Huan Wang Xin’an Wu Department of Pharmacy the First Hospital of Lanzhou UniversityLanzhou 730000 China School of Pharmacy Lanzhou UniversityLanzhou 730000 China The First Clinical Medical College of Lanzhou University Lanzhou 730000 China

Chronic renal failure(CRF)is a type of progressive chronic kidney disease with the alteration of substrates ***,changes in renal excretion pathways remain unclear in *** study aimed to evaluate the changes in renal excretion pathways of exogenous and endogenous substrates in CRF *** showed that the levels of cystatin C,creatinine,and urea nitrogen were dramatically increased in the adenine(50 or 100 mg/kg)-induced CRF *** levels of rOCT2 were dose-dependently up-regulated by adenine,and rMRP2 and rMATE1 levels were dose-dependently down-regulated,while rMRP4 was induced by adenine(50).Plasma concentrations of metformin,p-aminohippurate,and furosemide in the adenine(100)group were significantly increased compared with the control ***,plasma concentrations of metformin and p-aminohippurate were slightly changed in the adenine(50)***,urinary excretions of metformin and p-aminohippurate were *** addition,renal N1-methylnicotinamide uptakes were increased in rats treated with adenine,and renal phenyl-β-D-glucuronide and hippuric acid uptakes were induced by adenine(50).These results showed that adenine(100)-induced CRF caused the reduced function of GFR-r OCTs-r MATE1 and GFR-r OAT1/r OAT3-r MRP pathway,and oppositely the renal tubular transport pathways of rOCTs-r MATE1 and rOAT1-MRPs were induced in rats with the treatment of adenine(50).

关键词： Chronic renal failure renal excretion pathways Transporter Adenine

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