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Effects of different periods of renal ischemia on liver as a remote organ

World Journal of Gastroenterology 2009年第9期15卷 1113-1118页

作者： Mehri Kadkhodaee Fereshteh Golab Maryam Zahmatkesh Rana Ghaznavi Mehdi Hedayati Hossein Ali Arab Seyed Naser Ostad Manoocher Soleimani Department of Physiology School of MedicineTehran University of Medical Sciences14155-6447TehranIran Endocrine and Metabolism Research Center Shahid Beheshti University of Medical Sciences193954763TehranIran Department of Pharmacology School of Veterinary MedicineTehran University141556453 TehranIran Cell culture laboratory Faculty of PharmacyTehran University of Medical Sciences14155-6447TehranIran Department of Medicine University of CincinnatiMSB G259 OHUnited States

AIM:To assess the hepatic changes after induction of different periods of renal ischemia. METHODS:Rats were subjected to either sham operation or ischemia (30,45 and 60 min) followed by 60 min reperfusion. Liver and renal functional indices were measured. Hepatic glutathione (GSH) and ferric reducing antioxidant power levels and the concentration of interleukin (IL)-10 and tumor necrosis factor (TNF-α) were evaluated. Portions of liver and kidney tissues were fixed for histological evaluation. RESULTS:Forty-five minutes renal ischemia followed by 60 min reperfusion caused significant changes in liver structure and a significant reduction in renalfunction. These rats showed a significant decrease in liver GSH,as well as a significant increase in TNF-α and IL-10 concentrations. These results demonstrated that renal ischemia caused changes in liver histology,function,oxidative stress and inflammatory status,which led to a reduction in hepatic antioxidant capacity. With 30 min ischemia,the magnitude of these changes was less than those with 45 or 60 min ***:A minimum of 45 min ischemia is needed to study the effects of renal injury on the liver as a remote organ.

关键词： Renal ischemia Liver remote organ Oxidative stress Inflammation

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