检索结果-南通市图书馆

remote ischemic postconditioning protects against gastric mucosal lesions in rats

World Journal of Gastroenterology 2014年第28期20卷 9519-9527页

作者： Tao Wang Ye-Ting Zhou Xin-Nian Chen An-Xiang Zhu Bo-Hua Wu Department of Anesthesiology Shuyang People’s Hospital Department of General Surgery Shuyang People’s Hospital Institute of Pathophysiology School of Basic Medical SciencesLanzhou University Department of Pharmacy Shuyang People’s Hospital

AIM: To investigate the protective effects of remote ischemic postconditioning (RIP) against limb ischemia-reperfusion (IR)-induced gastric mucosal injury.

关键词： remote ischemic postconditioning Limb ischemia-reperfusion Gastric ischemia Protection Rat

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

remote ischemic postconditioning for ischemic Stroke： A Systematic Review and Meta-Analysis of Randomized Controlled Trials

引用

Chinese Medical Journal 2018年第8期131卷 956-965页

作者： Jing-Jing Zhao Hui Xiao Wen-Bo Zhao Xiao-Pei Zhang Yu Xiang Zeng-Jie Ye Miao-Miao Mo Xue-Ting Peng Lin Wei Department of Nursing Chongqing Medical and Pharmaceutical College Chongqing 401331 China Nursing Department Guangdong Province Hospital of Chinese Medicine Guangzhou University of Chinese Medicine Guangzhou Guangdong 510120 China Department of Nephrology The Third Affiliated Hospital of Sun Yat-Sen University Guangzhou Guangdong 510632 China Department of Neurology Guangdong Province Hospital of Chinese Medicine Guangzhou University of Chinese Medicine Guangzhou Guangdong 510120 China Department of Neurology Huaihua Hospital of Traditional Chinese Medicine Huaihua Hunan 418000 China Department of Economics and Management Guangzhou University of Chinese Medicine Guangzhou Guangdong 510120 China The Second Clinical Medical College Guangzhou University of Chinese Medicine Guangzhou Guangdong 510120 China

Background：remote ischemic postconditioning （RIPostC） appears to protect distant organs from ischemia-reperfusion injury （IRI）. However, cerebral protection results have remained inconclusive. In the present study, a meta-analysis was performed to compare stroke patients with and without ***：CNKI, WanFang, VIP, CBM, PubMed, and Cochrane Library databases were searched up to July 2016. Data were analyzed using both fixed-effects and random-effects models by Review Manager. For each outcome, risk ratio （RR） and mean difference （MD） with 95% confidence interval （CI） were ***：A total of 13 randomized controlled trials that enrolled a total of 794 study participants who suffered from or are at risk for brain IRI were selected. Compared with controls, RIPostC significantly reduced the recurrence of stroke or transient ischemic attacks （RR = 0.37; 95% CI： 0.26–0.55; P 〈 0.00001）. Moreover, it can reduce the levels of the National Institutes of Health Stroke Scale score （MD： 1.96; 95% CI： 2.18–1.75; P 〈 0.00001）, modified Rankin Scale score （MD： 0.73; 95% CI： 1.20–0.25; P = 0.00300）, and high-sensitivity C-reactive protein （MD： 4.17; 95% CI： 4.71–3.62; P 〈 0.00001） between the two groups. There was no side effect of RIPostC using tourniquet cuff around the limb on ischemic stroke treating based on different intervention ***：The present meta-analysis suggests that RIPostC might offer cerebral protection for stroke patients suffering from or are at risk of brain IRI.

关键词： ischemic Stroke Meta-Analysis remote ischemic postconditioning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Limb remote ischemic postconditioning protects integrity of the blood-brain barrier after stroke

引用

Neural Regeneration Research 2018年第9期13卷 1585-1593页

作者： Juan Li Xiao-Song Hu Fang-Fang Zhou Shuai Li You-Sheng Lin Wen-Qian Qi Cun-Fang Qi Xiao Zhang Experiment Technology Center of Preclinical Medicine of Chengdu Medical College Chengdu Sichuan Province China Department of Anatomy Qinghai University Xining Qinghai Province China

Integrity of the blood-brain barrier structure is essential for maintaining the internal environment of the *** of cerebral infarction and brain edema is strongly associated with blood-brain barrier ***,studies have suggested that protecting the blood-brain barrier may be an effective method for treating acute *** examine this possibility,stroke model rats were established by middle cerebral artery occlusion and *** ischemic postconditioning was immediately induced by three cycles of 10-minute ischemia/10-minute reperfusion of bilateral hind limbs at the beginning of middle cerebral artery occlusion *** function of rat models was evaluated using Zea Longa’s *** of the blood-brain barrier was assessed by Evans blue *** volume and brain edema were evaluated using 2,3,5-triphenyltetrazolium chloride *** of matrix metalloproteinase-9 and claudin-5 m RNA was determined by real-time quantitative reverse transcription-polymerase chain *** of matrix metalloproteinase-9 and claudin-5 protein was measured by western blot *** number of matrix metalloproteinase-9-and claudin-5-positive cells was analyzed using *** results showed that remote ischemic postconditioning alleviated disruption of the blood-brain barrier,reduced infarct volume and edema,decreased expression of matrix metalloproteinase-9 m RNA and protein and the number of positive cells,increased expression of claudin-5 m RNA and protein and the number of positive cells,and remarkably improved neurological *** findings confirm that by suppressing expression of matrix metalloproteinase-9 and claudin-5 induced by acute ischemia/reperfusion,remote ischemic postconditioning reduces blood-brain barrier injury,mitigates ischemic injury,and exerts protective effects on the brain.

关键词： nerve regeneration remote ischemic postconditioning middle cerebral artery occlusion cerebral ischemia/reperfusion blood-brain barrier acute cerebral ischemia stroke matrix metalloproteinase-9 claudin-5 neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A feasible strategy for focal cerebral ischemiareperfusion injury: remote ischemic postconditioning

引用

Neural Regeneration Research 2014年第15期9卷 1460-1463页

作者： Qiang Liu Shengnian Zhou Yaodong Wang Fang Qi Yuan Song Siwei Long Department of Neurology Qilu Hospital of Shandong University Brain Science Research Institute of Shandong University Department of Neurology Third Affiliated Hospital of Liaoning Medical University Department of Neurosurgery Third Affiliated Hospital of Liaoning Medical University

It is difficult to control the degree of ischemic postconditioning in the brain and other isch- emia-sensitive organs. remote ischemic postconditioning could protect some ischemia-sensitive organs through measures on terminal organs. In this study, a focal cerebral ischemia-reperftlsion injury model was established using three cycles of remote ischernic postconditioning, each cycle consisted of 10-minute occlusion of the femoral artery and 10-minute opening. The results showed that, remote ischemic postconditioning significantly decreased the percentage of the in- farct area and attenuated brain edema. In addition, inflammatory nuclear factor-KB expression was significantly lower, while anti-apoptotic Bcl-2 expression was significantly elevated in the ce- rebral cortex on the ischemic side. Our findings indicate that remote ischemic postconditioning attenuates focal cerebral ischemia/reperfusion injury, and that the neuroprotective mechanism is mediated by an anti-apoptotic effect and reduction of the inflammatory response.

关键词： nerve regeneration remote ischemic postconditioning focal cerebral ischemia neuropro-tection apoptosis inflammation brain injury nuclear factor-~B Bcl-2 neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：