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A multicenter retrospective study on the real-world outcomes of autologous vs. allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphoma in China

引用

Chinese Medical Journal 2021年第13期134卷 1584-1592页

作者： Zhen-Yang Gu Yu-Jun Dong Xiao-Rui Fu Nai-Nong Li Yao Liu Xiao-Xiong Wu Yi-Ni Wang Yu-Hang Li Han-Yun Ren Ming-Zhi Zhang Xiao-Fan Li Mai-Hong Wang Ya-Mei Wu Dai-Hong Liu Zhao Wang Liang-Ding Hu Wen-Rong Huang Department of Hematology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100071China Department of Hematology Peking University First HospitalBeijing 100034China Department of Oncology Zhengzhou University First Affiliated HospitalZhengzhouHenan 450000China Department of Hematology Fujian Institute of HematologyFuzhouFujian 350000China Center of Hematology Xinqiao HospitalArmy Medical UniversityChongqing 400037China Department of Hematology Capital Medical University Affiliated Beijing Friendship HospitalBeijing 100050China

Background:There were few studies on real-world data about autologous hematopoietic stem cell transplantation(auto-HSCT)or allogeneic HSCT(allo-HSCT)in peripheral T-cell lymphoma(PTCL).This study aimed to investigate the clinical outcomes of patients who received auto-HSCT or allo-HSCT in ***:From July 2007 to June 2017,a total of 128 patients who received auto-HSCT(n=72)or allo-HSCT(n=56)at eight medical centers across China were included in this *** retrospectively collected their demographic and clinical data and compared the clinical outcomes between ***:Patients receiving allo-HSCT were more likely to be diagnosed with stage III or IV disease(95%vs.82%,P=0.027),bone marrow involvement(42%vs.15%,P=0.001),chemotherapy-resistant disease(41%vs.8%,P=0.001),and progression disease(32%vs.4%,Premission(CR)undergoing auto-HSCT had better survival(3-year OS:88%vs.48%in allo-HSCT,P=0.008).For patients beyond CR,the outcome of patients who received allo-HSCT was similar to that in the atuo-HSCT group(3-year OS:51%vs.46%,P=0.300).Conclusions:Our study provided real-world data about auto-HSCT and allo-HSCT in ***-HSCT seemed to be associated with better survival for patients

关键词： Peripheral T-cell lymphoma Auto-HSCT Allo-HSCT PIT score remission status

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