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Occurrence Delays of Metastatic relapses of Breast Cancers Treated at University Hospital of Treichville (Abidjan-Cote d’Ivoire)

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Journal of Cancer Therapy 2017年第11期8卷 924-932页

作者： Lydie Estelle Djanhan Jean Marc Dia Boston Mian Mouhideen Oyelade Aboulaye Diallo Privat Guié Simplice Anongba Department of Gynecology and Obstetrics University Hospital of Bouaké Bouake Cote d’Ivoire Department of Gynecology and Obstetrics University Hospital of Treichville Abidjan Cote d’Ivoire Department of Gynecology and Obstetrics University Hospital of Cocody Abidjan Cote d’Ivoire

Objective: Describe the occurrence delays of metastatic relapses of breast cancer based on the characteristics of the original tumor. Methodology: This is a retrospective and cohort study conducted from January 2000 to December 2015 on patients with metastatic relapse of breast cancer. Results: Out of 178 patients collected, the metastatic relapses were estimated at 49%, occurring in patients with an average age of 53.4 years. The majority of the patients was educated (91.6%) and did not have a high socioeconomic level (88.2%). The initial tumors were mainly at a clinical stage III (47.8%), SBR grade III (47.2%), high index Ki 67 (46.5%), negative RH (79.3%) and HER2 negative (58%). Metastases were unique in general (62.9%), dominated by bone locations (36.6%), with an average age of occurrence of 2.4 years. After the occurrence of these metastases, the cumulative survival rate was 5% at 3 years, and zero to 5 years. Conclusion: Metastatic relapses were common with poor prognosis.

关键词： Breast Cancer Risk Factors Metastatic relapses

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When a liver transplant recipient goes back to alcohol abuse: Should we be more selective?

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World Journal of Gastroenterology 2016年第20期22卷 4789-4793页

作者： Monica Leon Joseph Varon Salim Surani Facultad de Medicina Universidad Popular Autonoma del Estado de Puebla Puebla Puebla 72410 Mexico Foundation Surgical Hospital of Houston Houston TX 77054 United States Texas A and M University Corpus Christi TX 78405 United States Pulmonary Associates Corpus Christi TX 78336 United States

Alcoholic liver disease(ALD) is one of the most common indications for liver transplantation(LT). However, it has always remained as a complicated topic from both medical and ethical grounds, as it is seen for many a "self-inflicted disease". Over the years, the survival rate of transplanted patients has significantly improved. The allocation system and the inclusion criteria for LT has also undergone some modifications. Early LT for acute alcoholic hepatitis has been subject to recent clinical studies with encouraging results in highly selected patients. We have learned from studies the importance of a multidisciplinary evaluation of candidates for LT. Complete abstinence should be attempted to overcome addiction issues and to allow spontaneous liver recovery. Risk factors for relapse include the presence of anxiety or depressive disorder, short duration of sobriety pre-LT and lack of social support. The identification of risk factors and the strengthen of social support system may decrease relapse among these patients. Family counseling of candidates is highly encouraged to prevent relapse to alcohol. Relapse has been associated with different histopathological changes, graft damage, graft loss and even decrease in survival among some studies. Therefore, each patient should be carefully selected and priority is to continue to lean on patients with high probability of success. The ethical issue remains as to the patient returning to drinking after the LT, hindering the way for other patients who could have received the same organ.

关键词： Liver transplantation Alcoholic liver disease Alcoholic cirrhosis Selection criteria relapses

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Epidemiological Aspects of Metastatic Relapse of Breast Cancer in an African Context

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Open Journal of Obstetrics and Gynecology 2017年第5期7卷 552-561页

作者： Jean Marc Dia Corneille Saki Oyeladé Mouhideen Eric Bohoussou Moctar Touré Gerard Okon Privat Guié Simplice Anongba Gynecology Department of the University and Hospital Center of Treichville (CHUT) Abidjan C&ocirc te d’Ivoire Cancerology Department of the University and Hospital Center of Treichville (CHUT) Abidjan C&ocirc te d’Ivoire

Objectives: This study aimed to describe the epidemiological characteristics of metastatic relapse in breast cancer at the University and Hospital Center of Treichville. Methodology: This is a cohort and retrospective study conducted from January 2000 to December 2015 on 178 patients with metastaticrelapse in breast cancer. Results: The prevalence of metastatic relapses was 49% and the patients had an average age of 53.4 years and among them, 91.6% received school education and 88.2% did not have a high socioeconomic level. The majority of initial tumors were in Stage III (47.8%), SBR III (47.2%), High Ki 67 (46.5%), Negative RH (79.3%), and HER2 negative (58%). Metastases were generally unique (62.9%), dominated by bone sites (36.6%), with an average occurrencedelay of 2.4 years. After the occurrence of metastases, the cumulative survival rate was 5% at 3 years, and nil at 5 years. Conclusion: Metastatic relapses were common with poor prognosis.

关键词： Breast Cancer Risk Factors Metastatic relapses

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