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Repressor elements provide insights into tissue development and phenotypes in pigs

Zoological Research 2024年第6期45卷 1313-1326页

作者： Yue-Dong Zhang Chao Guo Hang Liu Yun Gao Yongjun Tan Longjian Niu Ligang Wang Lixian Wang David MIrwin Chunhui Hou Zhong-Yin Zhou Ya-Ping Zhang Key Laboratory of Genetic Evolution&Animal models and Yunnan Key Laboratory of Molecular Biology of Domestic Animals Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan Yunnan UniversityKunmingYunnan 650091China School of Life Science Yunnan UniversityKunmingYunnan 650091China School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China State Key Laboratory of Hybrid Rice Hunan Hybrid Rice Research CenterHunan Academy of Agricultural SciencesChangshaHunan 410125China School of Public Health and Emergency Management Southern University of Science and TechnologyShenzhenGuangdong 518055China Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine Southern University of Science and TechnologyShenzhenGuangdong 518055China Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation of Ministry of Agriculture Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100081China Department of Laboratory Medicine and Pathobiology University of TorontoToronto M5S 1A8Canada Yunnan Key Laboratory of Biodiversity Information KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China

Repressor elements significantly influence economically relevant phenotypes in pigs;however,their precise roles and characteristics are inadequately *** the present study,we employed H3K27me3 profiling,assay for transposase-accessible chromatin with highthroughput sequencing(ATAC-seq),and RNA sequencing(RNA-seq)data across six tissues derived from three embryonic layers to identify and map 2034 super repressor elements(SREs) and 22223 typical repressor elements(TREs) in the pig ***,many repressor elements were conserved across mesodermal and ectodermal *** exhibited tight regulation of their target genes,affecting a limited number of genes within a specific genomic region with pronounced effects,while TREs exerted broader but weaker regulation over a wider range of target ***,in neuronal tissues,genes regulated by repressor elements started to be repressed during the differentiation of stem cells into progenitor ***,analysis showed that many repressor elements exhibited cooperative and additive effects on the modulation of KLF4 *** research provides the first comprehensive map of pig repressor elements,serving as an essential reference for future studies on repressor elements.

关键词： Repressor elements Super repressor elements Silencer regulatory model Tissue development KLF4 Pig

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Mode and Logic of Token Transaction Supervision

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Economics World 2023年第1期10卷 31-35页

作者： Shunyu Zhao Beijing Normal University-Hong Kong Baptist University United International College ZhuhaiChina

This paper mainly studies the attitude and supervision mode of various countries towards digital *** strength and methods of supervision in various countries are *** are cross-border transaction tokens and other chaotic *** is difficult to supervise and protect the interests of investors,which is not conducive to the healthy development of financial economy in various *** addition,with the development of globalization,digital tokens are going to the world and need to circulate among ***,a recognized regulatory principle is needed to ensure the healthy development of digital finance *** the goal of single independent law,with the help of“regulatory sandbox”and“white list”,we explore regulatory principles.

关键词： digital finance digital token regulatory model

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数字科技伦理监管：美国进展与中国借鉴

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伦理学 2023年第9期

作者：肖红军阳镇

新一轮数字技术产生了全新的数字经济形态和数字社会，但也引发了系列负外部性问题，数字科技伦理监管成为数字经济时代必须直面的重大现实议题，既有研究对数字科技伦理监管的理论框架、监管模式和主要议题缺乏深度解构。本文立足美国... 详细信息

新一轮数字技术产生了全新的数字经济形态和数字社会，但也引发了系列负外部性问题，数字科技伦理监管成为数字经济时代必须直面的重大现实议题，既有研究对数字科技伦理监管的理论框架、监管模式和主要议题缺乏深度解构。本文立足美国数字科技伦理监管的最新政策布局与监管实践，解析美国数字科技伦理监管的主要主体、监管模式和重点议题，搭建面向数字科技伦理监管的“监管主体—监管模式—监管机制”的一般性理论框架，研究发现，美国数字科技伦理监管主体涵盖“联邦政府—州政府—行业协会—企业”等多元主体，监管模式型侧重以国会为主导的美国政府立法与标准引领型监管、行业协会和研究机构等社会组织多元参与型监管，以及企业以数字科技伦理嵌入公司治理的嵌入型自治模式的三重主导模式，监管重点议题涵盖道德式人工智能与透明、公平和可解释的算法以及数据隐私与数据伦理等核心议题。中国加快构建数字科技伦理监管体系，需要强化数字科技伦理监管立法，在分层分类思路开展数字科技伦理制度设计和政策执行的基础上，需要进一步发挥地方数字科技伦理监管政策制定与执行的自主性原则，调动数字企业在数字科技伦理监管与治理方面的治理标准、行业规范、企业倡议、治理指南和操作手册等方面的引领作用。

关键词：数字科技伦理监管模式数字企业 digital technology ethics regulatory model digital enterprise

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