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Upadacitinib for refractory ulcerative colitis with primary nonresponse to infliximab and vedolizumab:A case report

World Journal of Clinical Cases 2024年第9期12卷 1685-1690页

作者： Xuan Xu Jing-Wen Jiang Bing-Yun Lu Xia-Xi Li Department of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhen 518100Guangdong ProvinceChina The First Clinical Medical School Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

BACKGROUND Many patients with ulcerative colitis(UC)do not respond well to,or tolerate conventional and biological *** is currently no consensus on the treatment of refractory *** have demonstrated that the selective Janus kinase 1 inhibitor upadacitinib,a small-molecule drug,is effective and safe for treating ***,no studies have revealed that upadacitinib is effective in treating refractory UC with primary nonresponse to infliximab and *** SUMMARY We report the case of a 44-year-old male patient with a chief complaint of bloody diarrhoea with mucus and pus,in addition to *** patient had recurrent disease after receiving mesalazine,prednisone,azathioprine,infliximab and vedolizumab over four *** on the endoscopic findings and pathological biopsy,the patient was diagnosed with refractory *** particular,the patient showed primary nonresponse to infliximab and *** on the patient’s history and recurrent disease,we decided to administer *** hospitalisation,the patient was received upadacitinib under our *** weeks after the initiation of upadacitinib treatment,the patient’s symptoms and endoscopic findings improved *** notable adverse reactions have been reported to *** Our case report suggests that upadacitinib may represent a valuable strategy for treating refractory UC with primary nonresponse.

关键词： Upadacitinib refractory ulcerative colitis Primary nonresponse Infliximab Vedolizumab Case report

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