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Dietary dimethylglycine sodium salt supplementation alleviates Redox status imbalance and intestinal dysfunction in weaned piglets with intrauterine growth restriction

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Animal Nutrition 2022年第3期10卷 188-197页

作者： Kaiwen Bai Luyi Jiang Qiming Li Jingfei Zhang Lili Zhang Tian Wang College of Animal Science and Technology Nanjing Agricultural UniversityNanjingChina College of Animal Science Zhejiang UniversityHangzhouChina

There are few studies on the mechanism of Redox status imbalance and intestinal dysfunction in intrauterine growth restricted(IUGR)newborn piglets.Here,we investigated the mechanism of jejunum dysfunction in weaned piglets with IUGR and the mechanism through which dimethylglycine sodium salt(DMG-Na)supplementation improving the imbalance of their Redox status.In this work,a total of 10 normal birth weight(NBW)newborn piglets and 20 IUGR newborn piglets were obtained.After weaning at 21 d,they were assigned to 3 groups(n=10/group):NBW weaned piglets fed standard basal diets(NBWC);one IUGR weaned piglets fed standard basal diets(IUGRC);another IUGR weaned piglets from the same litter fed standard basal diets plus 0.1%DMG-Na(IUGRD).The piglets in these 3 groups were sacrificed at 49 d of age,and the blood and jejunum samples were collected immediately.The growth performance values in the IUGRC group were lower(PRedox status of serum,jejunum,and mitochondria and the expression levels of jejunum Redox status-related,cell adhesion-related,and mitochondrial function-related genes and proteins were suppressed in the IUGRC group(PRedox status of serum,jejunum,and mitochondria,and the expression levels of jejunum Redox status-related,cell adhesion-related,and mitochondrial function-related genes and proteins were improved(PRedox status imbalance and intestinal dysfunction in IUGR weaned piglets mainly by activating the sirtuin 1(SIRT1)/peroxisome proliferatoractivated receptorgcoactivator-1a(PG

关键词： Intrauterine growth restriction Weaned piglet Jejunum Redox status Mitochondrial function Dimethylglycine sodium salt

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Dietary N-carbamylglutamate and L-arginine supplementation improves Redox status and suppresses apoptosis in the colon of intrauterine growth-retarded suckling lambs

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Animal Nutrition 2022年第4期11卷 359-368页

作者： Hao Zhang Yi Zheng Xia Zha Xiaoyun Liu Yi Ma Juan J.Loor Mabrouk Elsabagh Mengzhi Wang Hongrong Wang Honghua Jiang Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety The Ministry of Education of ChinaYangzhou UniversityYangzhou 225009China Department of Animal Sciences and Division of Nutritional Sciences University of IllinoisUrbanaIL61801USA Department of Animal Production and Technology Faculty of Agricultural Sciences and TechnologiesNigde Omer Halisdemir UniversityNigde 51240Turkey Department of Nutrition and Clinical Nutrition Faculty of Veterinary MedicineKafrelsheikh UniversityKafrelsheikh 33516Egypt Department of Pediatrics Northern Jiangsu People’s HospitalClinical Medical CollegeYangzhou UniversityYangzhou 225001China

Previous studies have revealed that dietary N-carbamylglutamate(NCG)or L-arginine(Arg)improves small intestinal integrity and immune function in suckling Hu lambs that have experienced intrauterine growth retardation(IUGR).Whether these nutrients alter Redox status and apoptosis in the colon of IUGR lambs is still unknown.This study,therefore,aimed at investigating whether dietary supplementation of Arg or NCG alters colonic Redox status,apoptosis and endoplasmic reticulum(ER)stress and the underlying mechanism of these alterations in IUGR suckling Hu lambs.Forty-eight 7-d old Hu lambs,including 12 with normal birth weight(4.25±0.14 kg)and 36 with IUGR(3.01±0.12 kg),were assigned to 4 treatment groups(n=12 each;6 males and 6 females)for 3 weeks.The treatment groups were control(CON),IUGR,IUGR+Arg and IUGR+NCG.Relative to IUGR lambs,superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)content,as well as proliferation index,were higher(PRedox status and suppress apoptosis via death receptor-dependent,mitochondrial and ER stress pathways in IUGR suckling lambs.

关键词： Colon Endoplasmic reticulum stress IUGR lambs L-arginine N-carbamylglutamate Redox status

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Elevated peroxidative glutathione Redox status in atherosclerotic patients with increased thickness of carotid intima media

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Chinese Medical Journal 2009年第23期122卷 2827-2832页

作者： HUANG Yan-sheng WANG Li-xia SUN Lin WU Yu LU Jian-min ZHAO Shi-chao DAI Fu-min XU Bo-shi WANG Shu-ren Department of Cardiology Henan Provincial People's HospitalZhengzhou Henan 450003 China Department of Pathophysiology West China School of Preclinicaland Forensic Medicine Sichuan University Chengdu Sichuan610041 China

Background Atherosclerosis is a chronic inflammatory disease. Accumulated evidences suggest a deep involvement of oxidative damage in the development of atherosclerosis, but little is discussed over the relationship between plasma glutathione Redox status as the most important intrinsic antioxidant defensive mechanism and the atherosclerosis. Methods A total of 132 patients suspected with atherosclerosis were assigned to three groups by high frequency ultrasonic examination of the carotid artery. With the thickness of intima of the carotid artery as an index of degree of atherosclerosis progression, 56 were included in plaque-forming group （A）, 42 in carotid artery intima-thickening group （B）, and 34 in normal carotid artery intima-thickness group （C）. All patients were subjected to the measurement of plasma glutathione （GSH）（reduced form GSH and oxidized form GSSG）, nicotinamide adenine dinucleotide phosphate （NADP）（reduced form NADPH and oxidized form NADP^＋）, oxidized low density lipoprotein （oxLDL）, and malondialdehyde （MDA） The GSH/GSSG and NADPH/NADP^＋ redox potentials were calculated according to the Nernst equation, and their correlation with intima thickness and oxLDL was analyzed. Results With the thickening of artery intima （from group C to A）, GSH concentration and the ratio of GSH/GSSG gradually reduced, and GSSG and GSH/GSSG redox potential gradually increased （more positive）（P 〈0.05）. The NADPH and NADPH/NADP^＋ Redox status also showed similar but milder changes. The products of oxidative stress oxLDL and MDA increased significantly along with the thickening of artery intima （P 〈0.05）. The analysis of the relationship between GSH/GSSG redox potential, intima thickness, and oxLDL showed positive correlations （P 〈0.05）. The plasma GSH/GSSG Redox status was positively correlated with the intima thickness of the carotid artery and the oxidized injury of LDL. The Redox status shifted to oxidizing direction along with the intima thickening and plaque-forming. Conclusion Elevated peroxidative glutathio

关键词： atherosclerosis Redox status glutathione nicotinamide adenine dinucleotide phosphate low density lipoprotein, oxidized

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Synchronous detection of glutathione/hydrogen peroxide for monitoring Redox status in vivo with a ratiometric upconverting nanoprobe

Synchronous detection of glutathione/hydrogen peroxide for m...

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第十一届全国化学生物学学术会议

作者： Judun Zheng Yunxia Wu Da Xing Tao Zhang MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science South China Normal University College of Biophotonics South China Normal University

Cellular Redox status presents broad implications with diverse physiological and pathological processes.Simultaneous detection of both the oxidative and reductive species of redox couples,especially the most representative pair glutathione/hydrogen peroxide(GSH/HO),is crucial to accurately map the cellular Redox status.However,it still remains challenging to synchronously detect GSH/HO in vivo due to lack of a reliable measuring tool.Herein,a ratiometric nanoprobe(UCNP-TB) possessing simultaneous delectability of GSH/HO is established based on a multi-spectral upconverting nanophosphor(UCNP-OA) as the luminescence resonance energy transfer(LRET) donor and two dye molecules as the acceptors,including a GSH-sensitive dye(TCG) and a HO-sensitive dye(BCH).With the as-prepared UCNP-TB,real-time and synchronous monitoring the variation of GSH and HO in vitro and in living mice can be achieved using the ratio of the upconversion luminescence(UCL) at 540 and 650 nm to that at 800 nm as the detection signal,respectively,providing highly inherent reliability of the sensing results by self-calibration.Moreover,the nanoprobe is capable of mapping the Redox status within the drug-resistant tumor and the drug-induced hepatotoxic liver via ratiometric UCL imaging.Thus,this nanoprobe would provide a reliable tool to elucidate the redox state in vivo.

关键词： Redox status glutathione hydrogen peroxide upconversion imaging nanoprobe

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Changes of the glutathione redox system during the weaning transition in piglets, in relation to small intestinal morphology and barrier function

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Journal of Animal Science and Biotechnology 2020年第4期11卷 993-1008页

作者： Jeroen Degroote Hans Vergauwen Wei Wang Chris Van Ginneken Stefaan De Smet Joris Michiels Laboratory for Animal Nutrition and Animal Product Quality(LANUPRO) Department of Animal Sciences and Aquatic EcologyFaculty of Bioscience EngineeringGhent UniversityBlock FCampus CoupureCoupure Links 6539000 GhentBelgium Laboratory of Applied Veterinary Morphology Department of Veterinary SciencesFaculty of BiomedicalPharmaceutical and Veterinary SciencesUniversity of AntwerpUniversiteitsplein 1WilrijkBelgium.

Background: Weaning is known to result in barrier dysfunction and villus atrophy in the immediate post-weaning phase, and the magnitude of these responses is hypothesized to correlate with changes in the glutathione(GSH)redox system. Therefore, these parameters were simultaneously measured throughout the weaning phase, in piglets differing in birth weight category and weaning age, as these pre-weaning factors are important determinants for the weaning transition. Low birth weight(LBW) and normal birth weight(NBW) littermates were assigned to one of three weaning treatments;i.e. weaning at 3 weeks of age(3 w), weaning at 4 weeks of age(4 w) and removal from the sow at 3 d of age and fed a milk replacer until weaning at 3 weeks of age(3 d3 w). For each of these treatments, six LBW and six NBW piglets were euthanized at 0, 2, 5, 12 or 28 d post-weaning piglets, adding up 180 piglets.Results: Weaning increased the glutathione peroxidase activity on d 5 post-weaning in plasma, and duodenal and jejunal mucosa. Small intestinal glutathione-S-transferase activity gradually increased until d 12 post-weaning, and this was combined with a progressive rise of mucosal GSH up till d 12 post-weaning. Oxidation of the GSH Redox status(GSH/GSSG Eh) was only observed in the small intestinal mucosa of 3 d3 w weaned piglets at d 5 postweaning. These piglets also demonstrated increased fluorescein isothiocyanate dextran(FD4) and horseradish peroxidase fluxes in the duodenum and distal jejunum during the experiment, and specifically demonstrated increased FD4 fluxes at d 2 to d 5 post-weaning. On the other hand, profound villus atrophy was observed during the weaning transition for all weaning treatments. Finally, LBW and NBW piglets did not demonstrate notable differences in GSH Redox status, small intestinal barrier function and histo-morphology throughout the experiment.Conclusion: Although moderate changes in the GSH redox system were observed upon weaning, the GSH Redox status remained at a steady state level in 3 w and 4 w weane

关键词： Barrier function Glutathione Oxidative stress Redox status Small intestine Weaned piglet

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain injury.Several drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system disorders.Although it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system disorders.In this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory role.Research targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells Redox status regeneration

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A Gene Expression Profiling of Early Rice Stamen Development that Reveals Inhibition of Photosynthetic Genes by OsMADS58

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Molecular Plant 2015年第7期8卷 1069-1089页

作者： Rui Chen Li-Ping Shen Dong-Hui Wang Fu-Gui Wang Hong-Yun Zeng Zhi-Shan Chen Yi-Ben Peng Ya-Nan Lin Xing Tang Ming-Hua Deng Nan Yao ding-Chu Luo Zhi-Hong Xu Shu-Nong Bai State Key Laboratory of Protein and Plant Gene Research College of Life Sciences Peking University Beijing 100871 China Center for Quantitative Biology Peking University Beijing 100871 China School of Mathematical Sciences Peking University Beijing 100871 China Center for Bioinformatics Peking University Beijing 100871 China State Key Laboratory of Biocontrol School of Life Sciences Sun Yat-sen University Guangzhou 510275 China The National Center of Plant Gene Research Beijing 100871 China State Key Laboratory of Protein and Plant Gene Research College of Life Sciences Peking University 624 Jin-Guang Life Science Building 5 Yiheyuan RoadBeijing 100871 China These authors contributed equally to this article.

Stamen is a unique plant organ wherein germ cells or microsporocytes that commit to meiosis are initiated from somatic cells during its early developmental process. While genes determining stamen identity are known according to the ABC model of floral development, little information is available on how these genes affect germ cell initiation. By using the Affymetrix GeneChip Rice Genome Array to assess 51 279 tran- scripts, we established a dynamic gene expression profile （GEP） of the early developmental process of rice （Oryza sativa） stamen. Systematic analysis of the GEP data revealed novel expression patterns of some developmentally important genes including meiosis-, tapetum-, and phytohormone-related genes. Following the finding that a substantial amount of nuclear genes encoding photosynthetic proteins are ex- pressed at the low levels in early rice stamen, through the ChlP-seq analysis we found that a C-class MADS box protein, OsMADS58, binds many nuclear-encoded genes participated in photosystem and light reac- tions and the expression levels of most of them are increased when expression of OsMADS58 is downre- gulated in the osmads58 mutant. Furthermore, more pro-chloroplasts are observed and increased signals of reactive oxygen species are detected in the osmads58 mutant anthers. These findings implicate a novel link between stamen identity determination and hypoxia status establishment.

关键词： rice early stamen development gene expression profile organ identity genes Redox status fate change

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Selenium promotes T-cell proliferative response to ConA,but not PHA in primary porcine splenocytes

Selenium promotes T-cell proliferative response to ConA,but ...

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中国畜牧兽医学会家畜内科学分会第七届代表大会暨学术研讨...

作者： John Hesketh Institute for Cell and Molecular Biosciences University of NewcastleThe Medical School Framlington PlaceNewcastle Upon Tyne NE2 4HHUK

There is controversy in the literature over whether the Selenium(Se) influences cellular immune responses,and the mechanisms possibly underlying these effects are unclear.In this study,the effects of Se on T-cell proliferation were studied in primary porcine splenocytes.Splenocytes were treated with different mitogens in the presence of 0.5 - 4μmol/L sodium selenite.Se significantly promoted Concanavalin A(ConA) -induced T-cell proliferation but failed to regulate Phytohemagglutinin(PHA)-induced T-cell proliferation in our study. However,Se significantly increased the levels of cellular glutathione peroxidase(GPx1) and thioredoxin reductase 1(TR1) mRNA,the activity of GPxl and the concentration of reduced glutathione(GSH) in the unstimulated, ConA or PHA-stimulated splenocytes.These results indicated that Se improved the Redox status in all splenocytes, including unstimulated,ConA and PHA-stimulated,but only ConA-induced T-cell proliferation was affected by the Redox status.N-acetylcysteine(NAC),a pharmacological antioxidant,promoted T-cell proliferative response to ConA,but not PHA in primary porcine splenocytes in the present study,which further confirmed that PHA-induced T-cell proliferation is insensitive to the Redox status.We conclude that Se promotes GPxl and TR1 expression and increases antioxidative capacity in porcine splenocytes.which enhances ConA-induced T-cell proliferation but not PHA-induced T-cell proliferation.The different susceptibilities to Se between the ConA and PHA-induced T-cell proliferation may help to explain the controversy in the literature over whether or not that Se boosts immune responses.

关键词： Selenium Porcine splenocytes mitogen Selenoproteins Gene expression Redox status

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Induction of apoptosis by excess of 2-selenium-bredged-Beta-cyclodexarin through depleting glutathione in cancer cells

Induction of apoptosis by excess of 2-selenium-bredged-Beta-...

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第九届全国酶学学术讨论会暨邹承鲁诞辰85周年纪念会

作者： Keyan Zheng Xiaofang Fei Shaowu Lv Ganglin Yan Guimin Luo Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education,Jilin University,Changchun 130021,China College of Life Science,Jilin University,Changchun 130021,China

Object:Investigation of the biological effect of 2-selenium-bridged β-cyclodextrin (2-SeCD) on cancer cells and its action mechanism.2-SeCD is a glutathione peroxidase mimic synthesized previously.The low concentrati... 详细信息

关键词： HeLa cells Redox status glutathione protein thiols caspase

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