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Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration

引用

Bioactive Materials 2021年第10期6卷 3461-3472页

作者： Shihao Zhang Yamin Li Xiaofeng Qiu Anqi Jiao Wei Luo Xiajie Lin Xiaohui Zhang Zeren Zhang Jiachan Hong Peihao Cai Yuhong Zhang Yan Wu Jie Gao Changsheng Liu Yulin Li The Key Laboratory for Ultrafine Materials of Ministry of Education State Key Laboratory of Bioreactor EngineeringEngineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China Institute of Translational Medicine Shanghai UniversityShanghai200444China Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy Mudanjiang Medical UniversityMudanjiang157011China Shanghai Jiaotong University Affiliated Sixth People’s Hospital Shanghai200233China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesCollege of Chemistry and Chemical EngineeringHubei UniversityWuhan430062China

Facing the high incidence of skin diseases,it is urgent to develop functional materials with high bioactivity for wound healing,where reactive oxygen species(ROS)play an important role in the wound healing process mainly via adjustment of immune response and *** this study,we developed a kind of bioabsorbable materials with ROS-mediation capacity for skin disease ***,redox-sensitive poly(N-isopropylacrylamide-acrylic acid)(PNA)nanogels were synthesized by radical emulsion polymerization method using a disulfide molecule as *** resulting nanogels were then incorporated into the nanofibrous membrane of poly(L-lactic acid)(PLLA)via airbrushing approach to offer bioabsorbable membrane with redox-sensitive ROS-balance *** vitro biological evaluation indicated that the PNA-contained bioabsorbable membrane improved cell adhesion and proliferation compared to the native PLLA *** vivo study using mouse wound skin model demonstrated that PNA-doped nanofibrous membranes could promote the wound healing process,where the disulfide bonds in them were able to adjust the ROS level in the wound skin for mediation of redox potential to achieve higher wound healing efficacy.

关键词： Polylactide Nanofibrous membrane redox sensitivity ROS-Balance capacity Skin regeneration

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