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Orange-derived extracellular vesicles nanodrugs for efficient treatment of ovarian cancer assisted by transcytosis effect

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Acta Pharmaceutica Sinica B 2023年第12期13卷 5121-5134页

作者： Feng Long Yao Pan Jinheng Li Suinan Sha Xiubo Shi Haoyan Guo Chuanqing Huang Qian Xiao Chao Fan Xingmei Zhang Jun-Bing Fan Ying Wang Cancer Research Institute Experimental Education/Administration CenterKey Laboratory of Functional Proteomics of Guangdong ProvinceSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Neurobiology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

Extracellular vesicles(EVs)have recently received much attention about the application of drug carriers due to their desirable properties such as nano-size,biocompatibility,and high ***,we demonstrate orange-derived extracellular vesicles(OEV)nanodrugs(DN@OEV)by modifying cRGD-targeted doxorubicin(DOX)nanoparticles(DN)onto the surface of OEV,enabling significantly enhancing tumor accumulation and penetration,thereby efficiently inhibiting the growth of ovarian *** obtained DN@OEV enabled to inducement of greater transcytosis capability in ovarian cancer cells,which presented the average above 10-fold transcytosis effect compared with individual *** was found that DN@OEV could trigger receptor-mediated endocytosis to promote early endosome/recycling endosomes pathway for exocytosis and simultaneously reduce degradation in the early endosomes-late endosomes-lysosome pathway,thereby inducing the enhanced *** particular,the zombie mouse model bearing orthotopic ovarian cancer further validated DN@OEV presented high accumulation and penetration in tumor tissue by the transcytosis *** study indicated the strategy in enhancing transcytosis has significant implications for improving the therapeutic efficacy of thedrugdelivery system.

关键词： Extracellular vesicles Transcytosis Cancer treatment Drug delivery system Targeted modification Receptor-mediated endocytosis Intracellular trafficking recycling endosome

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Targeted disruption of RablO causes early embryonic lethality

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Protein & Cell 2015年第6期6卷 463-467页

作者： Pingping Lv Yi Sheng Zhenao Zhao Wei Zhao Lusheng Gu Tao Xu Eli Song National Laboratory of Biomacromolecules institute of Biophysics Chinese Academy of Sciences Beiiin~l 100101 China University of Chinese Academy of Sciences Beijing 100049 China College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China

Dear Editor, Intracellular trafficking is a basis of cellular activities, including cell migration, immune response, and development （Lebreton et al., 2003; Lu（;in et al., 2014; Ulrich and Heisenberg, 2009）. In healthy tissue, intracellular trafficking is highly regulated, con- trolling the form and function of cells （Furthauer and Gonzalez- Gaitan, 2009）.

关键词： Early endosome Mutant Embryo recycling endosome Massive Cell Death Endosomal Trafficking

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