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The study on the safety and efficacy of amnion graft for preventing the recurrence of moderate to severe intrauterine adhesions

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Genes & Diseases 2020年第2期7卷 266-271页

作者： Changjiang Li Aiqi Cai Congcong Sun Benyuan Wu Xinpei Chen Yanhua Mao Yingfeng Zhang Yating Gou Jie Yu Yuhan Wang Huanhuan Yu Jia Wang Department of Obstetrics and Gynecology University-Town Hospital of Chongqing Medical UniversityChongqingChina

Transcervical resection of adhesion(TCRA)is the standard treatment for the intrauterine adhesions,but the recurrence of adhesions is a tough problem for the *** addition,the therapeutic strategy after TCRA about prevention of recurrence remains controversial especially for the patients with moderate to severe intrauterine adhesions(IUAs).Hence,we designed this study to explore the safety and efficacy of fresh amnion grafts for preventing the recurrence after TCRA for patients with moderate to severe *** hundred patients with moderate to severe IUAs who presented with a history of hypomenorrhea,amenorrhea and infertility were included in the study from January 2015 to December *** were divided into amnion group(52 patients)and chitosan group(48 patients).Fresh amnion grafts or intrauterine injections of chitosan were administered after *** ultrasonography(TVUS)and hysteroscopy were performed at the first and third month after the *** surgical procedures for all patients were completed successfully without relevant *** amnion group,8 patients exhibited relapse in the first month and 2 patients in three months after surgery;in chitosan group,23 women exhibited relapse in the first month and 18 patients in three months after *** analysis revealed that the recurrence rate of adhesion in amnion group was significantly lower than those of chitosan group in the first and three months after surgery(P1=0.000,P2=0.000).After TCRA,fresh amnion graft plays a significant role in preventing further adhesions than injections of chitosan.

关键词： Amnion graft Asherman’s syndrome Intrauterine adhesions recurrence of adhesion Transcervical resection of adhesion

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