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recovery of sympathetic nerve function after lumbar sympathectomy is slower in the hind limbs than in the torso

Neural Regeneration Research 2017年第7期12卷 1177-1185页

作者： Zhi-fang Zheng Yi-shu Liu Xuan Min Jian-bing Tang Hong-wei Liu Biao Cheng The Graduate School of Southern Medical University Guangzhou Guangdong Province China Department of Plastic Surgery Guangzhou General Hospital of Guangzhou Military Command Guangzhou Guangdong Province China The Graduate School of Third Military Medical Universitry Chongqing China Department of Plastic Surgery the First Affiliated Hospital of Jinan University Guangzhou Guangdong Province China Center of Wound Treatment Guangzhou General Hospital of Guangzhou Military Command Guangzhou Guangdong Province China The Key Laboratory of Trauma Treatment & Tissue Repair of Tropical Area of Chinese PLA Guangzhou Guangdong Province China

Local sympathetic denervation by surgical sympathectomy is used in the treatment of lower limb ulcers and ischemia,but the restoration of cutaneous sympathetic nerve functions is less *** study aims to explore the recovery of cutaneous sympathetic functions after bilateral L2-4 *** skin temperature of the left feet,using a point monitoring thermometer,increased intraoperatively after *** cytoplasm of sympathetic neurons contained tyrosine hydroxylase and dopamineβ-hydroxylase,visualized by immunofluorescence,indicated the accuracy of *** starch test results suggested that the sweating function of the hind feet plantar skin decreased 2 and 7 weeks after lumbar sympathectomy but had recovered by 3 *** and western blot assay results revealed that norepinephrine and dopamineβ-hydroxylase expression in the skin from the sacrococcygeal region and hind feet decreased in the sympathectomized group at 2 *** electron microscopy results showed that perinuclear space and axon demyelination in sympathetic cells in the L5 sympathetic trunks were found in the sympathectomized group 3 months after *** sympathetic denervation occurred in the sacrococcygeal region and hind feet skin 2 weeks after lumbar sympathectomy,the skin functions recovered gradually over 7 weeks to 3 *** conclusion,sympathetic functional recovery may account for the recurrence of hyperhidrosis after sympathectomy and the normalization of sympathetic nerve trunks after incomplete *** recovery of sympathetic nerve function was slower in the limbs than in the torso after bilateral L（2-4） sympathectomy.

关键词： nerve regeneration lumbar sympathectomy sympathetic nerve skin recovery of function neural regeneration

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Kinetics of testosterone recovery in clinically localized prostate cancer patients *** radical prostatectomy and subsequent short-term adjuvant androgen deprivation therapy

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Asian Journal of Andrology 2013年第4期15卷 466-470,I0006页

作者： Bo Dai Department of Urology Fudan University Shanghai Cancer Center Shanghai 200032 China Department of Oncology Fudan University Shanghai Medical College Shanghai 200032 China and Department of Pathology Fudan University Shanghai Cancer Center Shanghai 200032 China

deprivation therapy （ADT） is a standard treatment for metastatic, recurrent and locally advanced prostate cancer （PCa）. The aim of this study is to investigate the timing and extent of testosterone recovery in clinically localized PCa patients treated with radical prostatectomy （RP） and subsequent short-term adjuvant ADT. A total of 95 localized PCa patients underwent RP and 9-month adjuvant ADT were included in this prospective study. Serum testosterone level was measured before adjuvant ADT, at ADT cessation, and at 1, 3, 6, 9 and 12 months after cessation of ADT. A Cox proportional hazards model was used to assess variables associated with the ti me of testosterone normalization. The results showed that median patient age was 67 years and median testosterone level before adjuvant ADT was 361 （230-905） ng d1-1. All patients finished 9-month adjuvant ADT and achieved castrate testosterone level. At 3 months after ADT cessation, testosterone recovered to supracastrate level in 97.9% patients and to normal level in 36.9% patients. The percentage of patients who recovered to normal testosterone level increased to 66.3%, 86.3% and 92.6% at 6, 9 and 12 months, respectively. Cox regression model found that higher baseline testosterone level （ 300 ng dl- 1） was the only variable associated with a shorter time to testosterone normalization （hazard ratio： 1.98; P -- 0.012）. In conclusion, in most patients, testosterone recovered to supracastrate level at 3 months and to normal level at 12 months after 9-month adjuvant ADT cessation. Patients with higher baseline testosterone level need shorter time of testosterone normalization.

关键词： androgen deprivation therapy (ADT) luteinizing hormone-releasing hormone prostatic neoplasms recovery of function testosterone

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Multidisciplinary approach toward enhanced recovery after surgery for total knee arthroplasty improves outcomes

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World Journal of Clinical Cases 2024年第9期12卷 1549-1554页

作者： Deb Sanjay Nag Amlan Swain Seelora Sahu Ayaskant Sahoo Gunjan Wadhwa Department of Anaesthesiology Tata Main HospitalJamshedpur 831001India Department of Anaesthesiology Manipal Tata Medical CollegeJamshedpur 831001India

Knee osteoarthritis is a degenerative disorder of the knee,which leads to joint pain,stiffness,and inactivity and significantly affects the quality of *** an increased prevalence of obesity and greater life expectancies,total knee arthroplasty(TKA)is now one of the major arthroplasty surgeries performed for knee *** enhanced recovery after surgery(ERAS)was introduced in TKA,clinical outcomes were enhanced and the economic burden on the healthcare system was *** is an evidence-based scientific protocol aimed at ameliorating the surgical stress *** aims to enhance the recovery phase,which encompasses multidisciplinary strategies at every step of perioperative care,including the rehabilitation *** of ERAS in TKA aids in reducing the length of hospital stay,improving pain management,reducing perioperative complications,and enhancing patient *** collaboration,integrating the expertise of anesthesiologists,orthopedic surgeons,nursing personnel,and other healthcare professionals,is the cornerstone of ERAS in patients undergoing TKA.

关键词： Arthroplasty Replacement Knee recovery of function Anesthesia Care Nursing

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Hemiparesis in carotid cavernous fistulas (CCFs): a case report and review of the literature

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Chinese Journal of Traumatology 2004年第5期7卷 317-320页

作者：王慧晓白如林黄承光卢亦成张光霁 Department of Neurosurgery Changzheng Hospital Shanghai 200021 China

Carotid-cavernous fistulas (CCFs) are abnormal arteriovenous anastamoses between the carotid artery and the cavernous sinus. These fistulas may be classified by cause (spontaneous or traumatic), flow velocity (high or low), or pathogenesis (direct or indirect). The most commonly adopted classification is that described by Barrow based on arterial supply. Traumatic CCFs are almost always direct shunts between the internal carotid artery (ICA) and the cavernous sinus. General features of CCFs, which may be apparent with any lesion, including bruit, headache, loss of vision, altered mental status and neurological deficits. Some fistulae may present primarily with hemorrhage before any evaluation can be performed. However, hemiparesis has been rarely observed. Only a literature review of Murata et al reported a case of hemiparesis caused by posttraumatic CCF, in which the fistula resulted in venous hypertension and subsequent brainstem congestion. While in our case, cerebral infarction was caused by total steal of the blood flow. The patient recovered after occlusion of the fistula with a detachable balloon.

关键词： Adult Balloon Occlusion Carotid-Cavernous Sinus Fistula Cerebral Angiography Craniocerebral Trauma Follow-Up Studies Humans Male Paresis recovery of function Risk Assessment Severity of Illness Index Tomography, X-Ray Computed Treatment Outcome Wounds, Nonpenetrating

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Effect of bowel rehabilitative therapy on structural adaptation of remnant small intestine: animal experiment

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World Journal of Gastroenterology 2001年第1期7卷 66-73页

作者： Xin Zhou1 Yuan Xin Li2 Ning Li2 Jie Shou Li2 1Department of General Surgery, Medical School, Nanjing University, Nanjing 210093. Jiangsu Province. China2Research Institute of General Hospital. Chinese PLA General Hospital of Nanjing Military Area, Nanjing 210002. Jiangsu Province. China Research Institute of General Surgery Chinese PLA General Hospital of Nanjing Military Area 305 East Zhongshan Road Nanjing 210002 Jiangsu Province China.

AIM: To investigate the individual and the combined effects of glutamine, dietary fiber, and growth hormone on the structural adaptation of the remnant small bowel. METHODS: Forty-two adult male Sprague-Dawley rats underwent 85% mid-small bowel resection and received total parenteral nutrition (TPN) support during the first three postoperational *** the 4th postoperational day, animals were randomly assigned to receive 7 different treatments for 8 days: TPNcon group, receiving TPN and enteral 20 g x L(-1) glycine perfusion; TPN+Gln group, receiving TPN and enteral 20 g x L(-1) glutamine perfusion; ENcon group, receiving enteral nutrition (EN) fortified with 20 g x L(-1) glycine; EN+Gln group, enteral nutrition fortified with 20 g x L(-1) glutamine; EN+Fib group, enteral nutrition and 2 g x d(-1) oral soybean fiber; EN+GH group, enteral nutrition and subcutaneous growth hormone (GH) (0.3 IU) injection twice daily; and ENint group, glutamine-enriched EN, oral soybean fiber, and subcutaneous GH injection. RESULTS: Enteral glutamine perfusion during TPN increased the small intestinal villus height (jejunal villus height 250 microm +/- 29 microm in TPNcon vs 330 microm +/- 54 microm in TPN+Gln, ileal villus height 260 microm +/- 28 microm in TPNcon vs 330 microm +/- 22 microm in TPN+Gln, P<0.05) and mucosa thickness (jejunal mucosa thickness 360 microm +/- 32 microm in TPNcon vs 460 microm +/- 65 microm in TPN+Gln, ileal mucosa thickness 400 microm +/- 25 microm in TPNcon vs 490 microm +/- 11 microm in TPN+Gln,P< 0.05) in comparison with the TPNcon group. Either fiber supplementation or GH administration improved body mass gain (end body weight 270 g +/- 3.6g in EN+Fib, 265.7 g +/- 3.3 g in EN+GH, vs 257 g +/- 3.3 g in ENcon, P< 0.05), elevated plasma insulin-like growth factor (IGF-I) level (880 microg x L(-1). 52 microg x L-(-1) in EN+Fib,1200 microg x L(-1). 96 microg x L-(-1) in EN +/- GH, vs 620 microg x L(-1).43 microg x L-(-1) in ENcon, P< 0.05),

关键词： Parenteral Nutrition, Total Adaptation, Physiological Animals Body Weight Dietary Fiber Glutamine Glycine Growth Hormone Insulin-Like Growth Factor I Intestinal Mucosa Intestine, Small Male Rats Rats, Sprague-Dawley recovery of function Research Support, Non-U.S. Gov't Short Bowel Syndrome

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Selective neuronal PTEN deletion：can we take the brakes off of growth without losing control？

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Neural Regeneration Research 2016年第8期11卷 1201-1203页

作者： Erin A.Gutilla Oswald Steward Reeve-Irvine Research Center University of California Irvine School of Medicine Irvine CA USA Department of Anatomy & Neurobiology University of California Irvine School of Medicine Irvine CA USA Department of Neurobiology & Behavior University of California Irvine School of Medicine Irvine CA USA : Department of Neurosurgery University of California Irvine School of Medicine Irvine CA USA Center for the Neurobiology of Learning and Memory University of California Irvine School of Medicine Irvine CA USA

The limited ability for injured adult axons to regenerate is a major cause for limited functional recovery after injury to the nervous system,motivating numerous efforts to uncover mechanisms capable of enhancing regeneration *** promising strategy involves deletion or knockdown of the phosphatase and tensin（PTEN） *** genetic deletion of PTEN before,immediately following,or several months after spinal cord injury enables neurons of the corticospinal tract（CST） to regenerate their axons across the lesion,which is accompanied by enhanced recovery of skilled voluntary motor functions mediated by the *** conditional genetic deletion or knockdown of PTEN in neurons enables axon regeneration,PTEN is a well-known tumor suppressor and mutations of the PTEN gene disrupt brain development leading to neurological abnormalities including macrocephaly,seizures,and early *** long-term consequences of manipulating PTEN in the adult nervous system,as would be done for therapeutic intervention after injury,are only now being ***,we summarize evidence indicating that long-term deletion of PTEN in mature neurons does not cause evident pathology; indeed,cortical neurons that have lived without PTEN for over 1 year appear robust and *** to date provide only a first look at potential negative consequences of PTEN deletion or knockdown,but the absence of any detectable neuropathology supports guarded optimism that interventions to enable axon regeneration after injury are achievable.

关键词： PTEN roTOR spinal cord injury corticospinal tract motor system axon regeneration recovery of function

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Fracture healing with osteopathy in traditional Mongolian medicine

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Journal of Traditional Chinese Medicine 2013年第1期33卷 130-133页

作者： Namula Zhao Mei Wang Xueen Li Orthopedic Research Base of Inner Mongolian Nationality University for Nationalities Osteopathic Hospital of Traditional Mongolian Medicine in Tongliao Municipality Pharmacy College of Traditional Mongolian Medicine affiliated to Inner Mongolian Nationality University for Nationalities Automation Research Institute of China Academyof Sciences

OBJECTIVE: To explore the concept and norm of fracture healing with osteopathy in traditional Mongolian medicine (TMM). METHODS: Based on the correspondence between man and the universe (including psychosomatic integration) in fracture healing with osteopathy in TMM, we used modern physio-psychological and biomechanical principles and methods to probe the integrated, dynamic and functional characteristics of fracture healing. RESULTS: Based on the integration of limbs and the body, unification of the body and function and harmony of man and nature (including psychoso-matic integration), fracture healing with osteopathy in TMM comprises the concept of natural functional healing of fractures, and follows the norm of considering physiological healing and psychological function as well as limb healing and motor function. CONCLUSION: Fracture healing with osteopathy in TMM is characterized by a lack of trauma without future complications. This therapy makes the concept of fracture healing develop in the direction of humanity, behaviorism and integration.

关键词： Osteopathic medicine Fracture healing recovery of function Mental healing

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Clinical effect of distal radius fracture treated with open reduction and internal plate fixation

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Chinese Medical Journal 2012年第1期125卷 140-143页

作者： ZHANG Pei-xun XUE Feng DANG Yu WANG Tian-bing CHEN Jian-hai XU Hai-lin FU Zhong-guo ZHANG Dian-ying JIANG Bao-guo Peking University People＇s Hospital Beijing 100044 China

Background For some specific comminuted unstable intra-articular fracture,the plaster cast can not maintain the alignment of the articular surface *** aim of this study was to evaluate the clinical effects of distal radius fracture treated with open reduction and internal plate fixation *** From January 2002 to March 2010,539 cases of distal radius fracture were treated with open reduction and internal fixation,including 184 males and 355 females aging 21-72 years （mean 57 years）.Fractures were caused by falling to the ground in 459 cases,by traffic accident in 62 cases and by athletic injuries in 18 *** 539 cases,there were 523 cases of closed fracture and 16 cases of open *** to Arbeitsgemeinschaft fur Osteosynthesefragen （AO） standards of classification,there were 14 cases of A2 type,22 of A3 type,18 of B1 type,24 of B2 type,62 of B3 type,91 of C1 type,162 of C2 type and 146 of C3 *** time from injury to operation was 1-16 days （mean 5 days）.All patitents received open reduction and internal plate screw ***-seven patients with bone defect were given 6-15 g autologous ilium and 75 cases were given 5 ml calcium sulphate artificial aggregate after *** All incisions healed by first intention after *** were followed up for 15 to 32 months postoperatively （mean 22 months）.The fractures healed within 10-18 weeks after operation （mean 12 weeks）.During the last follow-up,the mean palmar tilt was （7.0±0.9）° and the mean ulnar variance was （21.0±4.2）°,showing significant difference when compared with preoperation （（-5.0±1.2）° and （8.0±3.8）°）.The radial heights were not *** to Gartland and Werley assessment system,the results were excellent in 314 cases,good in 163 cases,fair in 46 cases,and poor in 16 cases 12 weeks after operation,the excellent and good rate was 88.5%.Conclusions The clinical effect of distal radius fracture treated with open reduction and int

关键词： open reduction fracture fixation, internal recovery of function radius fracture

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The strength and function of hip abductors following anterolateral minimally invasive total hip arthroplasty

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Chinese Journal of Traumatology 2014年第2期17卷 73-78页

作者： Tan Jixiang Chen Hong Chen Cheng Liang Xi Huang Wei Department of Emergency & Critical Care Medicine First Affiliated Hospital Chongqing Medical UniversityChongqing 400016 China Department of Orthopedic Department First AffiliatedHospital Chongqing Medical University Chongqing400016 China

Objective： To analyze the extent of postoperative hip abductor insufficiency in primary total hip arthroplasty （THA） patients undergoing anterolateral minimally invasive （ALM1） approach, and to investigate whether the clinical outcomes are more favorable in femoral neck fracture （FNF） patients than in non-femoral neck fracture （nFNF） patients. Methods： A total of 48 patients were enrolled in this study. Each patient underwent a clinical examination preoperatively and 6, 12, 24 and 48 weeks postoperatively. The abductor torque, Trendelenburg＇s sign, gait velocity, Harris hip score, Oxford hip score, Westren Ontario and McMaster Universities （WOMAC） score and visual analog scale pain score were recorded. Statistical evaluation was performed with SPSS software version 18.0. The significance level was set at P〈0.05. Results： The abductor torque of the operated hip and the recovery ratio showed a gradual improving tendency from 6 weeks postoperatively until the last follow-up. Gait velocity, Harris hip score, Oxford hip score and WOMAC score improved significantly after the operation until 24 weeks postoperatively. In the FNF group, the abductor torque of the operated side and the recovery ratio were significantly higher than in nFNF group at 6 weeks postoperatively, however, as time passed, this trend tended to disappear. Conclusion： This study demonstrates that patients can obtain good abductor strength and function in the early postoperative period and the hip abductor function of patients who suffer from hip osteoarthritis, rheumatoid arthritis, avascular necrosis of the femoral head could be significantly improved following ALMI THA.

关键词： Arthroplasty, replacement, hip Surgical procedures, minimally invasive recovery of function

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Olfactory ensheathing cell transplantation in 106 patients with old spinal cord injury Differences in ages,sexes,disease courses,injured types and sites

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Neural Regeneration Research 2007年第6期2卷 380-384页

作者： Zuncheng Zheng Chao Liu Lin Zhang Rui Gao Shugang Wei Kun Zhang Lei Zhang Department of Neurosurgery Taian Rongjun Hospital of Shandong Province Taian 271000 Shandong Province China

BACKGROUND： It has been demonstrated that the transplantation of olfactory ensheathing cell （OEC） can promote the recovery of neurological function through ameliorating the local internal environment in spinal cord injury. OBJECTIVE： To evaluate the recent efficacy of OEC transplantation on old spinal cord injury. DESIGN： A self-controlled experiment. SETTING： Department ofNeurosurgery, Taian Rongjun Hospital of Shandong Province. PARTICIPANTS： Totally 106 inpatients with old spinal cord injury were selected from the Department of Neurosurgery, Taian Rongjun Hospital of Shandong Province from June 2004 to December 2006, including 97 males and 9 females. Inclusive criteria： ① Complete data; ② Informed with the fact; ③No further recover neurological function after drug therapy （neurotrophic factor, GM-1）, traditional Chinese medicine, physiotherapy and rehabilitative exercises; ④ No obvious compression of the injured spinal cord displayed by MRI examination. METHODS： ① The olfactory bulb was obtained from embryo of induced labor in middle pregnancy above 4 months supplied voluntarily by pregnant women, and the survived cells after purification and culture for 1 - 2 weeks were collected. Dura mater was incised by posterior approach, then the cultured OEC suspension was transplanted to corresponding regions by means of multi-target injection using microscope. ② The patients were evaluated for twice with the standards suggested by American Spinal Injury Association （ASIA） at admission and 2 - 4 weeks postoperatively, in order to investigate the efficacy in different age groups, different sites and at different time points after the OEC transplantation. ③ Standards for evaluation： The International Standard for Neurological and functional Classification of Spinal Cord Injury set by ASIA： The highest score of motor function was 100 points; The highest score of sensory function was 112 points for light touch and 112 for acupuncture sense. Frankel grading modified by ASIA in

关键词： olfactory spinal cord injuries transplantation recovery of function

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