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Expression of the Viral Antigen VP60 in Transgenic Potatoes and its Effect on the Nutritional Composition of Tubers

Food and Nutrition Sciences 2011年第2期2卷 74-86页

作者： Heike Mikschofsky Anja Hartmann Pawel Janczyk Günther M.Keil Patricia Konig Horst Schirrmeier Martin Hammer Holger Junghans Kerstin Schmidt Jorg Schmidtke Wolfgang B.Souffrant Manfred Schwerin Inge Broer Agrobiotechnologie Universitat RostockJustus-von-Liebig-WegGermany Research Group Functional Genomics Research Institute for the Biology of Farm Animals DummerstorfGermany Research Group Nutritional Physiology Research Institute for the Biology of Farm Animals DummerstorfGermany Friedrich-Loeffler-Institut SüduferGreifswald-Insel RiemsGermany Norika GmbH ParkwegGroB LüsewitzGermany BioMath GmbH ThünenplatzGroßLüsewitzGermany

recombinant plant-derived pharmaceuticals have been investigated for the last two decades and some products will soon be brought to market. Since veterinary pharmaceuticals seem to be the front-runners of plant-derived vaccines, we selected one model subunit vaccine, the structural capsid protein VP60 against rabbit haemorrhagic disease, and ana-lyzed the expression of three different sequences representing the vp60 open reading frame in potato plants. The gen-eration of antigenic VP60 molecules in the leaf and tuber tissue of potato was tremendously enhanced by replacing virus-derived sequences with plant-optimized codons. In order to identify potentially undesirable alterations in the composition of these genetically modified food components, we studied their nutrient composition and nutritional value in comparison to two parental conventional breeding varieties (Albatros and Desiree). The largest differences in nutrient composition were found between the two conventional breeds and between conventional Desiree and its near-isogenic genetically modified potato plant, indicating that genetic modification as well as conventional breeding can influence nutrient composition. Nevertheless, most parameters of nutritional value seemed to be more affected by conventional breeding than by genetic modification.

关键词： recombinant plant-derived vaccines VP60 RHDV Animal Nutrition Nutritional Assessment

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