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MK615 decreases RAGE expression and inhibits TAGE-induced proliferation in hepatocellular carcinoma cells

World Journal of Gastroenterology 2010年第42期16卷 5334-5341页

作者： Yuhki Sakuraoka Tokihiko Sawada Toshie Okada Takayuki Shiraki Yoshikazu Miura Katsuya Hiraishi Tatsushi Ohsawa Masakazu Adachi Jun-ichi Takino Masayoshi Takeuchi Keiichi Kubota Second Department of Surgery Dokkyo Medical UniversitySchool of MedicineKitakobayashi 880MibuShimotsugaTochigi 321-0293Japan Public Health Dokkyo Medical UniversitySchool of MedicineKitakobayashi 880MibuShimotsugaTochigi 321-0293Japan AdaBio Co.Ltd.21-1 Kenzaki-machiTakasakiGunma 370-0883Japan Department of Life Pharmacy Faculty of Pharmaceutical SciencesHokuriku UniversityHo-3Kanagawa-machiKanazawaIshikawa 920-1181Japan

AIM:To investigate the proliferative effect of advanced glycation end-products(AGEs) and the role of their cellular receptor(RAGE) on hepatocellular carcinoma(HCC) cells,and the inhibitory effects of MK615,an extract from Japanese apricot,against AGEs were also ***:Two HCC cell lines,HuH7 and HepG2,were *** of RAGE was investigated by poly-merase chain reaction,Western blotting,and flow cytemetry(FACS).The effect of MK615 on RAGE expression was also evaluated by *** proliferative effects of a control(unglycated bovine serum albumin),glucosederived AGEs(Glc-AGE),and glyceraldehyde-derived AGEs(Glycer-AGE),and the anti-proliferative effect of MK615 against AGEs,were evaluated using MTT ***:Expression of RAGE was confirmed at both the mRNA and protein levels in both HuH7 and *** revealed that the level of RAGE expression was higher in HuH7 than in *** with 0.1 μg/mL MK615 decreased the expression level of RAGE from 24.3% to 3.7% in HuH7 and from 6.2% to 4.8% in *** growth indices for the control,Glc-AGE,and Glycer-AGE were 1.06 ± 0.08,0.99 ± 0.04,and 1.38 ± 0.05,respectively,in HuH7(P = 0.037),and were 1.03 ± 0.04,1.04 ± 0.03,and 1.07 ± 0.05,respectively,in HepG2(P > 0.05).When the cells were cultured simultaneously with Glycer-AGE and MK615,MK615 abrogated the proliferative effect of Glycer-AGE in ***:Only Glycer-AGE has a proliferative effect on HuH7,which expresses a higher level of ***615 suppresses the proliferative effect of GlycerAGE on HuH7 by decreasing the expression of RAGE.

关键词： Hepatocellular carcinoma receptor of advanced glycation end-product advanced glycation endproducts MK615 Toxic advanced glycation end-products

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