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Cut-off values of lesion and vessel quantitative flow ratio in de novo coronary lesion post-drug-coated balloon therapy predicting vessel restenosis at mid-term follow-up

引用

Chinese Medical Journal 2021年第12期134卷 1450-1456页

作者： Pei-Na Meng Bin Liu Long-Bo Li De-Lu Yin Heng Zhang De-Feng Pan Wei You Zhi-Ming Wu Xiang-Qi Wu Lei Zhao Zhi-Bo Li Jin-Peng Wang Zhi-Hui Wang Tian Xu Xiao-Yu Huang Ruo-Nan Gao Fei Ye Department of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Department of Cardiology The Second Hospital of Jilin UniversityChangchunJilin 130000China Department of Cardiology The First People's Hospital of LianyungangLianyungangJiangsu 222000China Department of Cardiovascular Medicine The First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui 233000China Department of Cardiology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221006China

Background:Drug-coated balloons(DCBs)have emerged as potential alternatives to drug-eluting stents in specific lesion subsets for de novo coronary lesions.Quantitative flow ratio(QFR)is a method based on the three-dimensional quantitative coronary angiography and contrast flow velocity during coronary angiography(CAG),obviating the need for an invasive fractional flow reserve procedural.This study aimed to assess the serial angiographic changes of de novo lesions post-DCB therapy and further explore the cut-off values of lesion and vessel QFR,which predict vessel restenosis(diameter stenosis[DS]≥50%)at mid-term follow-up.Methods:The data of patients who underwent DCB therapy between January 2014 and December 2019 from the multicenter hospital were retrospectively collected for QFR analysis.From their QFR performances,which were analyzed by CAG images at follow-up,we divided them into two groups:group A,showing target vessel DS≥50%,and group B,showing target vessel DScharacteristics,parameters during DCB therapy,and QFR performances,which were analyzed by CAG images between the two groups,in need to explore the cut-off value of lesion/vessel QFR which can predict vessel restenosis.Student's t test was used for the comparison of normally distributed continuous data,Mann-Whitney U test for the comparison of non-normally distributed continuous data,and receiver operating characteristic(ROC)curves for the evaluation of QFR performance which can predict vessel restenosis(DS≥50%)at mid-term follow-up using the area under the curve(AUC).Results:A total of 112 patients with 112 target vessels were enrolled in this study.Group A had 41 patients,while group B had 71.Vessel QFR and lesion QFR were lower in group A than in group B post-DCB therapy,and the cut-off values of lesion QFR and vessel QFR in the ROC analysis to predict target vessel DS≥50%post-DCB therapy were 0.905(AUC,0.741[95%confidence interval,CI:0.645,0.837]

关键词： Quantitative flow ratio Drug-coated balloons De novo coronary lesions Cut-off value receiver operating characteristic curves

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