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Strongyloides stercoralis prevalence and diagnostics in Vientiane, Lao People’s Democratic Republic

Infectious Diseases of Poverty 2020年第5期9卷 118-119页

作者： Somaphone Chankongsin Rahel Wampfler Marie-Therese Ruf Peter Odermatt Hanspeter Marti Beatrice Nickel Valy Keoluangkhot Andreas Neumayr 不详 University of Basel BaselSwitzerland Department of Medicine Swiss Tropical and Public Health InstituteBaselSwitzerland

Background:Despite the high prevalence of strongyloidiasis in the Laotian population,Laotian hospitals still lack diagnostic capacity to appropriately diagnose Strongyloides stercoralis *** cross-sectional hospital-based study was conducted to assess the prevalence of Strongyloides stercoralis infection among hospitalized patients treated at Mahosot Hospital,the primary reference hospital of Lao People’s Democratic Republic(Lao PDR),and to validate feasible methods for diagnosing *** infection at hospital’s ***:Between September and December 2018,stool samples of 104 inpatients were investigated for *** infection by wet smear,Baermann technique,Koga Agar plate culture(KAPC),and real-time detection polymerase chain reaction(RTD-pcr)at the Infectious Diseases Ward of the Mahosot Hospital in *** sensitivity,the specificity,the negative predictive value(NPV)of each diagnostic test,as well as their combination(s)was calculated using a composite reference standard(CRS).The correlation of the different test methods was assessed by chi-square or Fisher’s exact ***’s kappa coefficient was used to assess the diagnostic agreement of the different test ***:The overall prevalence of *** infections among the study population was 33.4%.The cumulative infection prevalence statistically significantly increased from the lowest age group of 40 years and below(22.4%),to the medium(40.0%)and to the oldest age group of 61 year and above(72.7%)(P=0.003).The cumulative infection prevalence of CRS was considerably higher in male(40.4%)compared to female patients(28.1%),but not statistically different(P=0.184).The diagnostic sensitivity of Baermann technique,KAPC,RTD-pcr,and the combination of Baermann technique and KAPC were 60.0,60.0,74.3,and 77.1%,*** 13 patients(37.1%)of the total 35 *** patients diagnosed with any technique had a simultaneously positive diagnostic test with Baer

关键词： Strongyloides stercoralis Strongyloidiasis Wet smear Baermann method Koga agar plate culture real time detection pcr

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